Results 21 to 30 of about 363,743 (307)

Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells [PDF]

, 2013
Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic ...
Inoue-Yokoo, Tomoko, Lai, Mei I., Lim, Wai Feng, Sugiyama, Daisuke, Tan, Keai Sinn   +4 more
core   +1 more source

Effect in supralethally irradiated rats of granulocyte colony- stimulating factor and lisofylline on hematopoietic reconstitution by syngeneic bone marrow or whole organ passenger leukocytes [PDF]

, 1997
We have previously shown the existence of migratory hematopoietic stem cells in adult solid organs. This study demonstrates that granulocyte colony- stimulating factor (G-CSF) and lisofylline, a phosphatidic acid inhibitor that suppresses hematopoiesis ...
Abdul Rao, Angus W. Thomson, Anthony J. Demetris, Berry, Bociek, Clarke, Fontes, Foster, Foster, Lieschke, Lyman, Masanobu Terakura, Moore, Murase, Murase, Noriko Murase, Qing Ye, Schuening, Singer, Starzl, Tanikawa, Thomas E. Starzl, Toshiki Sakamoto, Uckun   +23 more
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The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. [PDF]

, 2018
Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs).
Li, Shengwen Calvin, Li, Zhongjun, Ran, Qian, Wu, Jiang, Xiang, Yang, Zhang, Weiwei, Zhong, Jiang F   +6 more
core   +2 more sources

Hematopoietic stem cell mobilization

Tzu Chi Medical Journal, 2022
ABSTRACT Hematopoietic stem cell (HSC) transplantation has been used to treat hematopoietic diseases for over 50 years. HSCs can be isolated from bone marrow (BM), umbilical cord blood, or peripheral blood. Because of lower costs, shorter hospitalization, and faster engraftment, peripheral blood has become the predominant ...
Hsin-Hou Chang, Yu-Shan Liou, Der-Shan Sun   +2 more
openaire   +3 more sources

The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor [PDF]

, 2013
Mobilized blood has supplanted bone marrow (BM) as the primary source of hematopoietic stem cells for autologous and allogeneic stem cell transplantation.
A Dar, A D’Souza, A Foudi, A Nagler, A Peled, AM Greenbaum, AW Roberts, B Nervi, CC Bleul, CL Semerad, D Obrecht, DE Harrison, F Ferraro, F Liu, GA Velders, GL Uy, H Balaguer, H Bonig, H Bonig, H Bonig, H Bonig, H Bonig, HE Broxmeyer, IG Winkler, JP Levesque, JP Levesque, K Balabanian, MA Pulsipher, MA Ryan, MJ Christopher, MM Mueller, MP Rettig, MZ Ratajczak, N Amariglio, P Anderlini, P Anderlini, P Anderlini, S Akizuki, SJ DeMarco, SJ Szilvassy, SM Devine, SP Fricker, T Lapidot, TA Lane, V Saini, WC Liles, Y Katayama, Y Takamatsu   +47 more
core   +1 more source

Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo [PDF]

, 2017
Human umbilical cord blood (CB) has attracted much attention as a reservoir for functional hematopoietic stem and progenitor cells, and, recently, as a source of blood-borne fibroblasts (CB-BFs). Previously, we demonstrated that bone marrow stromal cell (
Biondi, Andrea, Corsi, Alessandro, Donsante, Samantha, Pievani, Alice, Rambaldi, Benedetta, Remoli, Cristina, Riminucci, Mara, Robey, Pamela G., Sacchetti, Benedetto, Scagliotti, Valeria, Serafini, Marta, Vergani, Patrizia   +11 more
core   +2 more sources

Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL

Biomarker Research, 2020
Background Clinically relevant methods are not available that prioritize and validate potential therapeutic targets for individual tumors, from the vast amount of tumor descriptive expression data. Methods We established inducible transgene expression in
Wen-Hsin Liu, Paulina Mrozek-Gorska, Anna-Katharina Wirth, Tobias Herold, Larissa Schwarzkopf, Dagmar Pich, Kerstin Völse, M. Camila Melo-Narváez, Michela Carlet, Wolfgang Hammerschmidt, Irmela Jeremias   +10 more
doaj   +1 more source

In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets

Nature Communications, 2021
Preclinical molecular models are useful that mimic a patient´s response to targeted therapy. Here, the authors establish an in vivo inducible RNAi-mediated gene silencing system in patient-derived xenograft models of acute leukemia to identify individual
Michela Carlet, Kerstin Völse, Jenny Vergalli, Martin Becker, Tobias Herold, Anja Arner, Daniela Senft, Vindi Jurinovic, Wen-Hsin Liu, Yuqiao Gao, Veronika Dill, Boris Fehse, Claudia D. Baldus, Lorenz Bastian, Lennart Lenk, Denis M. Schewe, Johannes W. Bagnoli, Binje Vick, Jan Philipp Schmid, Alexander Wilhelm, Rolf Marschalek, Philipp J. Jost, Cornelius Miething, Kristoffer Riecken, Marc Schmidt-Supprian, Vera Binder, Irmela Jeremias   +26 more
doaj   +1 more source

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]

, 2018
Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat, Broxmeyer, Hal E., Huang, Xinxin, Trinh, Thao   +3 more
core   +1 more source

Association of Interleukin 10 (IL-10) Gene Polymorphism (819T > C) with Susceptibility to Acute Myeloid Leukemia: A Meta-Analysis

Iranian Journal of Public Health, 2022
Background: Studies reported an association between interleukin (IL)-10 -819T>C polymorphism and the risk of developing Acute myeloid leukemia (AML), however due to inconsistency among these results, relationship between IL-10 -819T>C polymorphism and ...
Hamid Reza Ahadi, Amin Ebrahimi Sadrabadi, Arsalan Jalili, Abbas Hajifathali   +3 more
doaj   +1 more source