Results 311 to 320 of about 1,175,170 (409)

Optimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration

BMEMat, EarlyView.
Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu, Chung Yin Matthew Cheung, Liling Liu, Hoi Pan Harry Cheung, Kam Yu Tam, Dai Fei Elmer Ker, Sarah H. Cartmell, Chuanbin Mao, Zhiyong Zhang, Dan Michelle Wang   +9 more
wiley   +1 more source

Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells. [PDF]

Cancer Discov
Struys I, Velázquez C, Ubels J, LeJeune CL, van Roosmalen MJ, Rosendahl Huber AKM, van Leeuwen AJCN, Bossuyt W, Thienpont B, Voet T, Van Calsteren K, Lenaerts L, van Boxtel R, Amant F.   +13 more
europepmc   +1 more source

The INSPECTOR study: enhanced feasibility for clinical translation of a multi‐cancer early detection method based on enzyme‐assisted high signal‐to‐noise ratio sequencing of methylated circulating tumor DNA

Cancer Communications, EarlyView.
Abstract Background Blood‐based cell‐free DNA (cfDNA) methylation testing has emerged as a promising approach for multi‐cancer early detection (MCED), holding the potential to improve cancer survival rates. However, traditional bisulfite‐based methods often encounter sensitivity limitations in detecting early‐stage malignancies or certain cancer types.
Hui‐Yan Luo, Wei Wei, Pansong Li, Qi‐Hua Zhang, Zhipeng Zhou, Liang Cui, Yong‐Bin Lin, Hong Yang, Xianyu Zhong, Qingfeng Liu, Han Yang, Kong‐Jia Luo, Hai‐Bo Qiu, Shu‐Qiang Yuan, Yuan‐Fang Li, Zhi‐Wei Zhou, Xiao‐Jun Lin, Bo‐Kang Cui, Rong‐Xin Zhang, Wen‐Hua Fan, He Huang, Chun‐Yan Lan, Jun‐Dong Li, Zhi‐Qiang Wang, Bin‐Kui Li, Rong‐Ping Guo, Jun Tang, Xin Huang, Mian Xi, Yuying Liu, Chuanbo Xie, Shi Chen, Zhi‐Hu Li, Yu‐Hua Liu, Xiao‐Ting Zhang, Qiang Zeng, Xin Yi, Rui‐Hua Xu   +37 more
wiley   +1 more source

Phase separation participates in the genetic regulation mechanism of hematopoietic stem cells: potential therapeutic methods. [PDF]

Stem Cell Res Ther
Tang X, Wang Y, Xu R.
europepmc   +1 more source

The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma

Chemistry &Biodiversity, EarlyView.
ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha, Danielle Twilley, Mona Dawood, Thomas Efferth, Namrita Lall   +4 more
wiley   +1 more source

Contemporary and Emerging Therapies in the Management of Refractory Angina: A Clinical Review

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Refractory angina (RA) represents a growing challenge in clinical cardiology, particularly in patients with obstructive coronary artery disease (CAD) who remain symptomatic despite optimal medical therapy and who are not candidates for revascularization.
Alex Angers‐Goulet, Siddhartha Mengi, David Garcia Labbé, Can Manh Nguyen, Jean‐Michel Paradis   +4 more
wiley   +1 more source

Mechanism of umbilical cord mesenchymal stem cells in the expansion of umbilical cord blood-derived hematopoietic stem cells in vitro. [PDF]

J Int Med Res
Bian ZY, Xu L.
europepmc   +1 more source

Hemangiopericytoma following allogeneic hematopoietic stem cell transplantation in a patient with primary plasma cell leukemia: the first case report and literature review

Yajun Shi, Guangyao Liang, Haiying Zhang, Yaqing Wang, Ying Han, Shanbao Tong, Shunyu Liang, Ying‐Ping Wang, Hai Bai, Rui Xi   +9 more
openalex   +1 more source

Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Asciminib is the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP) in patients with chronic myeloid leukemia. This phase 1, two‐treatment‐period, drug‐drug interaction study evaluated the effect of steady‐state asciminib on the pharmacokinetics of atorvastatin.
Matthias Hoch, Wendy Weis, Felix Huth, Seshulatha Jamalapuram, Michelle Quinlan, Amarnath Bandaru, Suleyman Eralp Bellibas, Asmae Mirkou, Shruti Kapoor, Shefali Kakar   +9 more
wiley   +1 more source

Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition. [PDF]

Blood Adv
Williams MJ, Wang X, Bastos HP, Grondys-Kotarba G, Wu Q, Jin S, Johnson C, Mende N, Calderbank E, Wantoch M, Park HJ, Mantica G, Hannah R, Wilson NK, Pask DC, Hamilton TL, Kinston SJ, Asby R, Sneade R, Baxter EJ, Campbell P, Vassiliou GS, Laurenti E, Li J, Göttgens B, Green AR.   +25 more
europepmc   +1 more source