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Birth Defects Research Part C: Embryo Today: Reviews, 2003
AbstractConsiderable effort has been made in recent years in defining the embryonic origin of the hematopoietic stem cell (HSC). Using transgenic mouse models, a number of genes that regulate the formation, self‐renewal, or differentiation of HSCs have been identified. Of particular interest, it has recently been shown that key regulators of definitive
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AbstractConsiderable effort has been made in recent years in defining the embryonic origin of the hematopoietic stem cell (HSC). Using transgenic mouse models, a number of genes that regulate the formation, self‐renewal, or differentiation of HSCs have been identified. Of particular interest, it has recently been shown that key regulators of definitive
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Hematopoietic stem cells and their niche [PDF]
Trends in Immunology, 2005 Recent evidence indicates that osteoblasts are crucial components of the particular microenvironments, or niches, for hematopoietic stem cells (HSCs) in adult bone marrow (BM). Stem cells persist in an immature state within the BM. The quiescence of HSCs is controlled dynamically by the signaling of receptors-ligands and cell-adhesion molecules.
Atsushi Hirao, Toshio Suda, Fumio Arai
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Thrombopoietin and the Hematopoietic Stem Cell
Blood, 1998Abstract: The molecular mechanisms that underlie the favorable effects of thrombopoietin on stem cell survival, self‐renewal, and expansion are unknown. On the basis of known effects of HoxB4, HoxA9, and vascular endothelial cell growth factor on stem cells, we explored whether TPO might affect these pathways.
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Hematopoietic Stem Cells and Aging
Experimental Gerontology, 1999The question of whether hematopoietic stem cells are altered in aging has been the subject of considerable controversy for over two decades. The substantial advancement of knowledge on hematopoietic stem cells and developmental hematology in the last few years has reopened this issue for critical analysis.
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Characterization of Hematopoietic Stem Cells
Annals of the New York Academy of Sciences, 1995On the basis of density-separated mononuclear cells isolated from bone marrow, peripheral blood, and cord blood, we have repeatedly shown good correlation between two-color flow cytometric (FACS) CD34 analysis and colony formation in the clonogenic assay.
Agnes Leitner +7 more
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Current Opinion in Immunology, 2014
Aging is organized in a hierarchy, in which aging of cells results in aged tissues, ultimately limiting lifespan. For organ systems that also in the adult depend on stem cells for tissue homeostasis like the hematopoietic system that forms immune cells, it is believed that aging of the stem cells strongly contributes to aging-associated dysfunction. In
Hartmut Geiger +3 more
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Aging is organized in a hierarchy, in which aging of cells results in aged tissues, ultimately limiting lifespan. For organ systems that also in the adult depend on stem cells for tissue homeostasis like the hematopoietic system that forms immune cells, it is believed that aging of the stem cells strongly contributes to aging-associated dysfunction. In
Hartmut Geiger +3 more
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The aging of hematopoietic stem cells [PDF]
Nature Medicine, 1996 We have purified hematopoietic stem cells (HSCs) from the bone marrow of old mice and compared their properties to HSCs in young and middle-aged mice. Single, reconstituting HSCs (by limit dilution) from old and young mice exhibited indistinguishable progenitor activities in vivo. HSCs were five times as frequent in the bone marrow of old mice; however,
Koichi Akashi +4 more
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Hematopoietic Stem Cells [PDF]
, 1995 The definition of any stem cell is that it is a cell type which is capable of multi-lineage differentiation, and self-renewal; self-renewal means regeneration of more stem cells, as measured by phenotype and function.
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Hematopoietic Stem Cells [PDF]
, 2009 Hematopoietic stem cells (HSCs) represent one of the first amenable experimental models that enhanced our understanding of stem cell behavior. Features of the hematopoietic system facilitating the early development of this experimental model include the fact that the hematopoietic system is a naturally regenerative organ comprising cells that are ...
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Hematopoietic stem cell expansion
Transfusion Science, 1997This review addresses two issues: (1) cytokine-mediated expansion of functional end cells for the abrogation of short term neutropenia and thrombopenia following high dose chemotherapy and (2) cytokine-driven increase in absolute numbers of functional stem cells.
Jean Ripoche +2 more
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