Results 51 to 60 of about 416,052 (359)

Homeodomain transcription factor Meis1 is a critical regulator of adult bone marrow hematopoiesis. [PDF]

PLoS ONE, 2014
Hematopoietic stem cells in the bone marrow have the capacity to both self-renew and to generate all cells of the hematopoietic system. The balance of these two activities is controlled by hematopoietic stem cell-intrinsic regulatory mechanisms as well ...
Reina Ariki, Satoru Morikawa, Yo Mabuchi, Sadafumi Suzuki, Mayuka Nakatake, Kentaro Yoshioka, Shinya Hidano, Hiromitsu Nakauchi, Yumi Matsuzaki, Takuro Nakamura, Ryo Goitsuka   +10 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

ABI3BP promotes renal aging through Klotho-mediated ferroptosis

Journal of Translational Medicine
The aging process of the kidneys is accompanied with several structural diseases. Abnormal fiber formation disrupts the balance of kidney structure and function, causing to end-stage renal disease and subsequent renal failure.
Ren Ji, Lin Wei, Yuxin Zan, Xiao Li, Shinan Ma, Liming Ma, Xiju He, Li Wang, Yan Ding   +8 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Trimethylamine N-oxide promotes the proliferation and migration of hepatocellular carcinoma cell through the MAPK pathway

Discover Oncology
Trimethylamine-n-oxide (TMAO) is a metabolite of intestinal flora following the consumption of phosphatidylcholine-rich foods. Clinical cohort studies have shown that plasma TMAO may be a risk factor for cancer development, including hepatocellular ...
Chunfang Zhou, Rina Basnet, Chenxiang Zhen, Shinan Ma, Xingrong Guo, Zhongxia Wang, Yahong Yuan   +6 more
doaj   +1 more source

The Impact of Mesenchymal Stem Cells on Differentiation of Hematopoietic Stem Cells [PDF]

Advanced Pharmaceutical Bulletin, 2015
Bone marrow microenvironment contains cellular and acellular compartments. The cellular compartment includes hematopoietic stem cells, mesenchymal stem cells and some other stromal cell types, while the acellular compartment is composed of scaffold ...
Mahshid Saleh, karim Shamsasanjan, Aliakbar Movassaghpourakbari, Parvin Akbarzadehlaleh, Zahra Molaeipour   +4 more
doaj   +1 more source

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: children and adolescents [PDF]

, 2021
Juliana Moura Nabarrete, Andréa Z Pereira, Adriana Garófolo, Adriana Seber, Ângela Venâncio, Carlos Eduardo Setanni Grecco, Carmem Bonfim, C.H. Nakamura, Daieni Fernandes, Denise Johnsson Campos, Fernanda Luísa Ceragioli Oliveira, Flávia Krüger Cousseiro, Flávia Rossi, Jocemara Gurmini, Karina Viani, Luciana Fernandes Guterres, Luiz Fernando Alves Lima Mantovani, Luiz Guilherme Darrigo, Maria Isabel Brandão Pires e Albuquerque, Melina Brumatti, Mirella Aparecida Neves, Natalia Flores Durán, Neysimélia Costa Villela, Victor Gottardello Zecchin, Juliana Folloni Fernandes   +24 more
openalex   +1 more source

Leukemia cell microvesicles promote survival in umbilical cord blood hematopoietic stem cells [PDF]

, 2015
Microvesicles can transfer their contents, proteins and RNA, to target cells and thereby transform them. This may induce apoptosis or survival depending on cell origin and the target cell.
Kafi-abad, Sedigheh Amini, Karimi, Mohammad Hossein, Mehrabani, Davood, Razmkhah, Farnaz, Soleimani, Masoud   +4 more
core  

Preclinical correction of human Fanconi anemia complementation group A bone marrow cells using a safety-modified lentiviral vector. [PDF]

, 2010
One of the major hurdles for the development of gene therapy for Fanconi anemia (FA) is the increased sensitivity of FA stem cells to free radical-induced DNA damage during ex vivo culture and manipulation.
Adair, J, Beard, BC, Becker, PS, Chien, S, Kiem, H-P, Kohn, DB, Shimamura, A, Taylor, JA, Trobridge, GD, Wagner, JE, Zhao, X   +10 more
core   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source