Results 61 to 70 of about 224,203 (310)

Human kidney-derived hematopoietic stem cells can support long-term multilineage hematopoiesis

, 2023
International audienceLong-term multilineage hematopoietic donor chimerism occurs sporadically in patients who receive a transplanted solid organ enriched in lymphoid tissues such as the intestine or liver. There is currently no evidence for the presence
Karkeni, Esma, Romain Berthaud, Boyer, Olivia, Berthaud, Romain, Bénédicte Neven, Isabelle André, Steicy Sobrino, Capucine Picard, Toubert, Antoine, Dehoux, Laurène, Patrick Villarese, Chantal Lagresle-Peyrou, Villarese, Patrick, Tifanie Blein, Salomon, Rémi, André, Isabelle, Julien Zuber, Nathalie Gouge-Biebuyck, Blein, Tifanie, Emmanuel Clave, Marina Cavazzana, Emmanuelle Six, Olivia Boyer, Vahid Asnafi, Six, Emmanuelle, Zuber, Julien, Adeline Denis, Asnafi, Vahid, Kergaravat, Camille, Chrystelle Abdo, Antoine Toubert, Abdo, Chrystelle, Soëli Charbonnier, Cavazzana, Marina, Rémi Salomon, Clave, Emmanuel, Elizabeth Macintyre, Marion Alcantara, Macintyre, Elizabeth, Neven, Bénédicte, Sobrino, Steicy, Albinni, Souha, Souha Albinni, Alcantara, Marion, Charbonnier, Soëli, Camille Kergaravat, Denis, Adeline, Gouge-Biebuyck, Nathalie, Lagresle-Peyrou, Chantal, Esma Karkeni, Picard, Capucine, Laurène Dehoux, Blanche, Stéphane, Stéphane Blanche   +53 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Therapeutic adenine base editing of human hematopoietic stem cells

, 2023
Here, Liao and colleagues apply adenine base editor ABE8e and its PAM-less variant ABE8e-SpRY to β-thalassemia patient hematopoietic stem cells in the form of ribonucleoprotein complexes, resulting in efficient long-term editing and β-thalassemia ...
Xin Wang, Shenlin Hsiao, Yuanjin Zhang, Jiaoyang Liao, Yongrong Lai, Shuanghong Chen, Yanhong Jiang, Daniel E. Bauer, Yuxuan Wu, Yang Yang   +9 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

DNMT3b's Role in Hematopoietic Stem Cells [PDF]

, 2010
Hematopoiesis proceeds from a bone marrow resident population of stem cells responsible for generation of all lineages within the blood. Distinct molecular programs within hematopoietic stem cells regulate maintenance of this population under homeostatic
Boyer, Matthew Jacob
core  

Comparative diagnostic performance of imaging modalities in chronic pancreatitis: a systematic review and Bayesian network meta-analysis

BMC Medical Imaging
Purpose We aimed to perform a Bayesian network meta-analysis to assess the comparative diagnostic performance of different imaging modalities in chronic pancreatitis(CP).
Ping Yu, Xujia Zhou, Li Yue, Ling Zhang, Yuan Zhou, Fei Jiang   +5 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Effects of Participation in Volunteer Activities on CD34+ Hematopoietic Stem Cells

Aging populations face health challenges, and volunteering may improve health outcomes. This study investigated the relationship between volunteering, CD34+ hematopoietic stem cells, and health indicators in older adults.
Chang, Chuan-Hsin;Chen, Chia-Chi;Chang, Yue-Cune;Hsieh, Cho Chen;Lin, Chai Ching;Lee, Jia-Fu
core   +1 more source

Role of Flk-1 in mouse hematopoietic stem cells

, 2001
It was reported that human hematopoietic stem cells in bone marrow were restricted to the CD34+KDR+ cell fraction. We found that expression levels of Flk-1, a mouse homologue of KDR, were low or undetectable in mouse Lin−c-Kit+Sca-1+CD34low/− cells as ...
Todokoro, Kazuo, Nagata, Yuka, Haruta, Hirotaka   +2 more
core   +1 more source

P423: ADAPTING CRISPR CAS9 DROPOUT SCREENS TO IN VIVO PDX MODELS OF ACUTE LEUKEMIAS

HemaSphere, 2022
R. Ludwig, D. Amend, E. Bahrami, I. Jeremias   +3 more
doaj   +1 more source