Results 51 to 60 of about 224,203 (310)
Exploiting natural and induced genetic variation to study hematopoiesis [PDF]
, 2011 PUZZLING WITH DNA Blood cell formation can be studied by making use of natural genetic variation across mouse strains. There are, for example, two mouse strains that do not only differ in fur color, but also in average life span and more specifically in ...
Gerrits, Alice,, Gerrits, Alice
core
Discover OncologyTrimethylamine-n-oxide (TMAO) is a metabolite of intestinal flora following the consumption of phosphatidylcholine-rich foods. Clinical cohort studies have shown that plasma TMAO may be a risk factor for cancer development, including hepatocellular ...
Chunfang Zhou +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Cellular and Molecular Life SciencesDisruptions in energy metabolism within skeletal cells play a critical role in the pathogenesis of diabetic osteoporosis (DOP), primarily by affecting bone’s metabolic balance.
Peng Tuo +12 more
doaj +1 more source
Homeodomain transcription factor Meis1 is a critical regulator of adult bone marrow hematopoiesis. [PDF]
PLoS ONE, 2014 Hematopoietic stem cells in the bone marrow have the capacity to both self-renew and to generate all cells of the hematopoietic system. The balance of these two activities is controlled by hematopoietic stem cell-intrinsic regulatory mechanisms as well ...
Reina Ariki +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Extrinsic Regulation of Hematopoietic Stem Cells in Health and Disease
, 2018 Hematopoietic stem cells facilitate lifelong production of a diverse repertoire of functional mature blood cells. They are a critical biological reservoir that enable organisms to endure physiological challenges such as inflammation, disease, and age ...
Decker, Matthew
core +2 more sources
Transposable elements in hematopoietic stem cells upon aging and myeloid malignancies
Mobile DNATransposable elements (TEs) constitute nearly half of the human genome and profoundly influence hematopoietic stem cell (HSC) biology. In this review, we synthesize current evidence demonstrating that TEs exert dual and context-dependent roles in HSCs ...
Emilie Elvira-Matelot, Françoise Porteu
doaj +1 more source
Cryopreservation of hematopoietic stem cells [PDF]
American Journal of Hematology, 2007 AbstractStem cell transplantation represents a critical approach for the treatment of many malignant and non‐malignant diseases. The foundation for these approaches is the ability to cryopreserve marrow cells for future use. This technique is routinely employed in all autologous settings and is critical for cord blood transplantation.
David, Berz +4 more
openaire +2 more sources
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source