Results 21 to 30 of about 248,268 (245)

A telomerase em células-tronco hematopoéticas Telomerase in hematopoietic stem cells

Revista Brasileira de Hematologia e Hemoterapia, 2008
A proliferação das células-tronco hematopoéticas sofre a perda dos telômeros a cada divisão celular. Alguns autores discordam quanto à perda ou não do potencial proliferativo e capacidade de auto-renovação das células mais diferenciadas. Revisaremos aqui
Silvana Perini, Lúcia M. R. Silla, Fabiana M. Andrade   +2 more
doaj   +1 more source

Genotoxic aldehydes in the hematopoietic system [PDF]

Blood, 2022
Abstract Reactive aldehydes are potent genotoxins that threaten the integrity of hematopoietic stem cells and blood production. To protect against aldehydes, mammals have evolved a family of enzymes to detoxify aldehydes, and the Fanconi anemia DNA repair pathway to process aldehyde-induced DNA damage.
Meng Wang, Felix A. Dingler, K. J. Patel
openaire   +2 more sources

Consequences of long-term exposure to ionizing radiation on the hematopoietic system of fish in the water bodies of the Chornobyl Exclusion Zone [PDF]

Ядерна фізика та енергетика
The hematological parameters of the common rudd Scardinius erythrophthalmus, roach Rutilus rutilus, perch Perca fluviatilis and Prussian carp Carassius gibelio from the most radionuclide-contaminated water bodies of the Chornobyl Exclusion Zone were ...
N. A. Pomortseva, D. I. Gudkov, N. К. Rodionova, O. Ye. Kaglyan   +3 more
doaj   +1 more source

Mutations of Recombinant Aquaporin-4 Antibody in the Fc Domain Can Impair Complement-Dependent Cellular Cytotoxicity and Transplacental Transport

Frontiers in Immunology, 2018
Maternal antibodies provide protection for the developing fetus. Transplacental transport of pathogenic autoantibodies might pose a risk for the developing fetus. The transport of antibodies across the placenta to the fetal circulation occurs through the
Simone Mader, Lior Brimberg, John N. Soltys, Jeffrey L. Bennett, Jeffrey L. Bennett, Betty Diamond   +5 more
doaj   +1 more source

Homeodomain transcription factor Meis1 is a critical regulator of adult bone marrow hematopoiesis. [PDF]

PLoS ONE, 2014
Hematopoietic stem cells in the bone marrow have the capacity to both self-renew and to generate all cells of the hematopoietic system. The balance of these two activities is controlled by hematopoietic stem cell-intrinsic regulatory mechanisms as well ...
Reina Ariki, Satoru Morikawa, Yo Mabuchi, Sadafumi Suzuki, Mayuka Nakatake, Kentaro Yoshioka, Shinya Hidano, Hiromitsu Nakauchi, Yumi Matsuzaki, Takuro Nakamura, Ryo Goitsuka   +10 more
doaj   +1 more source

Assessment of toxic interaction of lead and chromium metals in binary mixture in quails: A hematological study

Public Health and Toxicology
Introduction Overpopulation and global trends toward industrialization are continuously affecting the environment in terms of pollution. The heavy metals in industrial effluents are considered the prime environmental toxicants, which are regarded as ...
Muhammad J. Sadiq, Saira Amir, Muhammad S. Majid   +2 more
doaj   +1 more source

Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease

Cells, 2019
Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The role of AQP4 has been studied in health and in a range of pathological conditions.
Simone Mader, Lior Brimberg
doaj   +1 more source

A synthetic three-dimensional niche system facilitates generation of functional hematopoietic cells from human-induced pluripotent stem cells

Journal of Hematology & Oncology, 2016
Background The efficient generation of hematopoietic stem cells (HSCs) from human-induced pluripotent stem cells (iPSCs) holds great promise in personalized transplantation therapies.
Yulin Xu, Wei Shan, Xia Li, Binsheng Wang, Senquan Liu, Yebo Wang, Yan Long, Ruxiu Tie, Limengmeng Wang, Shuyang Cai, Hao Zhang, Yu Lin, Mingming Zhang, Weiyan Zheng, Yi Luo, Xiaohong Yu, Jiing-Kuan Yee, Junfeng Ji, He Huang   +18 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Health Effects of Ionizing Radiation on the Human Body

Medicina
Radioactivity is a process in which the nuclei of unstable atoms spontaneously decay, producing other nuclei and releasing energy in the form of ionizing radiation in the form of alpha (α) and beta (β) particles as well as the emission of gamma (γ ...
Jasminka Talapko, Domagoj Talapko, Darko Katalinić, Ivan Kotris, Ivan Erić, Dino Belić, Mila Vasilj Mihaljević, Ana Vasilj, Suzana Erić, Josipa Flam, Sanja Bekić, Suzana Matić, Ivana Škrlec   +12 more
doaj   +1 more source