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Photoradiation Therapy with Hematoporphyrin Derivative in the Management of Brain Tumors

, 1986
Hematoporphyrin is a naturally occurring compound similar to the heme of hemoglobin without the iron ligand (Fig. 1). Since the observation by Lipson44–46 in 1960 that a derivative of hematoporphyrin (HpD) had superior tumor localizing characteristics when compared to hematoporphyrin, all subsequent clinical studies have used HpD.
Robert E. Wharen, Robert E. Anderson, Edward R. Laws   +2 more
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Hematoporphyrin derivative photoradiation induced damage to normal and tumor tissue of the pigmented rabbit eye

Current Eye Research, 1984
Cytotoxicity induced by hematoporphyrin derivative (HpD) photoradiation in both normal and experimental tumor tissue of pigmented rabbit eyes has been examined. In addition, documentation of HpD induced fluorescence in ocular structures has also been obtained.
C J, Gomer, D R, Doiron, L, White, J V, Jester, S, Dunn, B C, Szirth, N J, Razum, A L, Murphree   +7 more
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Treatment of intraocular tumors with hematoporphyrin derivative photoradiation therapy.

Conference on Lasers and Electro-Optics, 1984
Hematoporphyrin derivative (HpD) photoradiation therapy (PRT) is currently being examined for the treatment of intraocular tumors. HpD is taken up in malignant tissue, and tumorcidal action can be induced when HpD is activated with visible red light. Preclinical studies have been performed to examine the pharmacology of HpD and the toxicology of HpD ...
Charles J. Gomer, A. Linn Murphree, Daniel R. Doiron, Nicholas J. Razum, Stanley W. Fountain   +4 more
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Early Detection of Lung Cancer by Means of Hematoporphyrin Derivative Fluorescence and Laser Photoradiation

Clinics in Chest Medicine, 1985
In recent years hematoporphyrin derivative (HpD), a mixture of porphyrin compounds that have an increased affinity for malignant tissue, has been used as an endobronchial tumor indicator to facilitate the bronchoscopic localization of early squamous cell carcinoma of the central tracheobronchial tree. In this article the authors describe four different
H, Kato, D A, Cortese
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Hematoporphyrin Derivative and Laser Photoradiation in the Diagnosis and Treatment of Bladder Cancer

Journal of Urology, 1983
Diagnosis and treatment of 8 patients with malignant bladder tumors were performed with intravenous administration of hematoporphyrin derivative, followed by krypton-ion laser violet light photoradiation and argon-dye laser red light photoradiation therapy.
A, Tsuchiya, N, Obara, M, Miwa, T, Ohi, H, Kato, Y, Hayata   +5 more
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Hematoporphyrin derivative photoradiation treatment of experimental malignant melanoma in the anterior chamber of the rabbit

Current Eye Research, 1985
The effects of Hematoporphyrin Derivative Photoradiation Therapy (HpD-PRT) on Greene's amelanotic melanoma implanted into the anterior chamber of rabbits have been examined by biomicroscopy, fluorescein angiography and histopathology. The tumors were irradiated 24 hours after injection of HpD when both the porphyrin concentration and the porphyrin ...
Franken, K. A., van Delft, J. L., Dubbelman, T. M., de Wolff-Rouendaal, D., Oosterhuis, J. A., Star, W. M., Marijnissen, H. P.   +6 more
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Photoradiation Therapy with Hematoporphyrin Derivative and an Argon Dye Laser of Bladder Carcinoma

, 1984
Hematoporphyrin Derivative (HpD) which has an affinity for malignant tumors is excited by light exposure and reacts photodynamically in tumor tissue. Therefore it is possible to treat malignant tumor selectively without any damage to surrounding normal tissues. HpD is excited by a light in the spectrum from ultraviolet to visible red.
Tetsutaro Ohi, Harubumi Kato, Akira Tsuchiya, Nobuo Obara, Koichi Imamura, Katsuo Aizawa, Chimori Konaka, Jutaro Ono, Norihiko Kawate, Kazuo Yoneyama, Makoto Saito, Hidenobu Takahashi, Sumiyaki Tsukimura, Hideki Shinohara, Johnson Lay, Yoshihiro Hayata   +15 more
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Hematoporphyrin derivative and photoradiation therapy of malignant tumors

Plastic and Reconstructive Surgery, 1984
David B. Apfelberg
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The acute effects of hematoporphyrin derivative photoradiation on tumor and liver capillary blood flow.

Microcirculation, endothelium, and lymphatics, 1991
The acute effects of photoradiation after administering hematoporphyrin derivative (Hpd) on capillary blood flow were studied in intrahepatic tumors and normal liver. The tumors were solitary Walker carcinosarcomas implanted within the livers of Sprague-Dawley rats.
Robert M. J. Jacobs, Ackerman Nb, Bloom Nd, Kim Dd   +3 more
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Hematoporphyrin Derivative Photoradiation Therapy Applied in Gynecology

Journal of Gynecologic Surgery, 1986
Helmut F. Schellhas, David Schneider
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