Results 111 to 120 of about 735 (172)

Hematoporphyrin derivative photoradiation therapy of the rat 9L gliosarcoma brain tumor model

Lasers in Surgery and Medicine, 1984
AbstractThe distribution of hematoporphyrin derivative (HPD) in the rat 9L gliosarcoma intracerebral brain tumor model at 4, 24, 48, and 72 hours after intravenous administration was evaluated using a digital video fluorescence microscopy technique. Maximum tissue fluorescence in the normal brain was observed at 4 hours, whereas maximum fluorescence in
James E. Boggan, Michael S. B. Edwards, Catherine A. Bolger, Michael W. Berns, Robert Walter   +4 more
exaly   +5 more sources

Photoradiation Therapy with Hematoporphyrin Derivative in Early and Stage 1 Lung Cancer

Chest, 1984
Photoradiation therapy with hematoporphyrin derivative was used in 13 cases of early-stage and eight cases of stage 1 central-type lung cancer. The lesions were photoradiated superficially or interstitially by an argon dye laser with a power of 80 to 600 mW for 10 to 40 minutes at 48 hours or more after intravenous injection of 2.5 to 5.0 mg of ...
Yoshihiro Hayata, Harubumi Kato, Chimori Konaka, Ryuta Amemiya, Jutaro Ono, Ippei Ogawa, Komei Kinoshita, Harumasa Sakai, Hidenobu Takahashi   +8 more
exaly   +5 more sources

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Hematoporphyrin‐Derivative and Photoradiation Therapy of Malignant Tumors

Lasers in Surgery and Medicine, 1983
AbstractKodak projectors with #2418 red Corning filters were used as a light source to treat cutaneous and subcutaneous malignancies in five patients who previously had been given hematoporphyrin derivative (HpD). An argon dye laser system was used to treat malignancies in patients who also were given the HpD.
J S, McCaughan, J T, Guy, P, Hawley, W, Hicks, W, Inglis, L, Laufman, E, May, T A, Nims, R, Sherman   +8 more
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Intra-Abdominal Applications of Hematoporphyrin Photoradiation Therapy

, 1983
At Roswell Park Memorial Institute (RPMI), long experience in the management of tumors with hematoporphyrin derivative (HPD) photoradiation therapy (PRT) has documented the destruction of a wide range of neoplasms with remarkable regularity (1,2). The surrounding inflammatory response and eschar that formed at the site of the tumor nodule indicated ...
H. O. Douglass, Hector Nava, K. R. Weishaupt, D. Boyle, M. G. Sugerman, Ethan J. Halpern, Thomas J. Dougherty   +6 more
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Hematoporphyrin Photoradiation Therapy for Intraocular and Orbital Malignant Melanoma

Archives of Ophthalmology, 1984
Photoradiation therapy (PRT) is a new technique that is currently under investigation for the treatment of a variety of solid malignant tumors. The technique involves systemic administration of hematoporphyrin derivative (HpD), a photosensitizing compound that is preferentially retained by malignant cells and photoactivation of the neoplasm with red ...
D T, Tse, J J, Dutton, T A, Weingeist, V M, Hermsen, R C, Kersten   +4 more
openaire   +4 more sources

Hematoporphyrin Derivative Photoradiation Therapy

Archives of Ophthalmology, 1984
To the Editor. —I read with interest the article in the JulyArchivesregarding hematoporphyrin derivatives in photoradiation therapy. 1 I found a number of references to this subject appearing in the literature. When I introduced porphyrins to clinical medicine in 1955, at the Johns Hopkins Hospital, Baltimore, 2 I originally used it as a surgical tool.
David R. Taxdal
  +5 more sources

AN ATOMIC BASIS OF CANCER—PHOTORADIATION THERAPY AND HEMATOPORPHYRIN DERIVATIVE

International Journal of PIXE, 1991
The principles of photoradiation therapy employing a tumor-seeking agent such as a hematoporphyrin derivative are described. The properties and preparation of hematoporphyrin derivatives and metalloporphyrin synthesis are briefly summarized. We show that PIXE analysis can be used to indicate the degree of a synthesis.
Chau-Chin Wei, CHIH-SHANG WEI
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Bactericidal Effects of Photoradiation Therapy With Hematoporphyrin Derivative

Journal of Infectious Diseases, 1985
Hematoporphyrin derivative (Hpd) localizes selectively in malignant and rapidly metabolizing tissues and undergoes a cytotoxic reaction when exposed to light of a specific wavelength. Hpd has been studied extensively with regard to the diagnosis and treatment of tumors but not with regard to bactericidal activity. This investigation assessed the effect
Frank R. Venezio, C. A. DiVincenzo, Roger T. Sherman, Marsha E. Reichman, Thomas C. Origitano, Kim D. Thompson, Orna Reichman   +6 more
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Hematoporphyrin derivative photoradiation therapy in managing nevoid basal-cell carcinoma syndrome

Archives of Ophthalmology, 1984
Hematoporphyrin derivative (HpD) is a photodynamically active dye that is preferentially retained by malignant tissues and initiates a cytotoxic reaction when exposed to red light. Normal tissues adjacent to a tumor retain HpD to a lesser degree and are thus spared damage from the light-induced reaction.
Tse Tse, KERSTEN, ANDERSON
  +5 more sources

Hematoporphyrin Derivative Photoradiation Therapy of Endobronchial Lung Cancer

, 1984
Hematoporphyrin derivative (HpD) photoradiation therapy (PRT) has been reported as an effective treatment for a variety of tumors (1,2). This technique relys on the tumor localizing and photosensitization potential of HpD to selectively destroy tumors.
Daniel R. Doiron, Oscar J. Balchum
openalex   +2 more sources