Results 101 to 110 of about 735 (172)
Evaluation of hematoporphyrin photoradiation therapy to treat choroidal melanomas
Lasers in Surgery and Medicine, 1984 AbstractHematoporphyrin derivative‐photoradiation therapy (HPD‐PRT) was used to treat choroidal melanomas in 23 human subjects. Tumor sizes were divided into three categories: less than 500 mm3 (11 patients), 500‐1,000 mm3 (four patients), and greater than 1,000 mm3 (eight patients). Tumors were exposed to 630 nm laser light at total doses of 300‐3,000
Robert A. Bruce
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DNA damage and repair in CHO cells following hematoporphyrin photoradiation
Cancer Letters, 1980 The induction and repair of alkali labile lesions and single strand breaks in DNA of CHO cells following HpD photoradiation of X-irradiation has been examined. For treatments producing equal survival levels, the amount of DNA damage was less for HpD-photoradiated cells compared to X-irradiated cells.
Charles J. Gomer
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Photoradiation of rabbit ocular malignant melanoma sensitized with hematoporphyrin derivative
Current Eye Research, 1984 Photoradiation therapy (PRT) against the Greene-Harvey amelanotic malignant melanoma on the rabbit iris was effectively used to cause tumor regression. A dose of 2.5 mg/kg of hematoporphyrin derivative (HPD) given intravenously, followed by photoradiation at a wavelength of 632 nm and a power density as low as 71 mW/cm2 for 24 minutes (102 J/cm2) was ...
Theodore W. Sery, Thomas J. Dougherty
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Hematoporphyrin derivative photoradiation therapy in murine solid tumors
Cancer Letters, 1983 The cytocidal activity of light-activated hematoporphyrin derivative (Hpd) in experimental and human tumors is under investigation in many laboratories. This activity is based upon preferential incorporation of Hpd in malignant tissues and its photosensibilization by red light. Treatment of mice bearing MS-2 fibrosarcoma and B16 melanoma, a metastastic
Gianfranco Canti +7 more
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Hematoporphyrin derivative and photoradiation therapy in early stage lung cancer
Lasers in Surgery and Medicine, 1984 AbstractPhotoradiation therapy (PDT) with administration of hematoporphyrin derivative (HPD) was performed in ten cases of early stage central‐type lung cancer of which six cases were treated by PRT alone due to inoperability because of poor pulmonary function I five and refusal of surgery on one. Four cases were resected after PRT.
Yoshihiro Hayata +7 more
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Laser photoradiation therapy of cancer following hematoporphyrin sensitization
Lasers in Surgery and Medicine, 1982 AbstractHematoporphyrin derivative‐photoradiation therapy (HPD‐PRT) of human malignancy has been performed on 267 tumor sites in 50 patients. Tumor response has been assayed at 24 hours and one month following treatment with 625–635 nm light from an argon laser‐pumped dye laser.
Alan G. Wile +3 more
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