Results 91 to 100 of about 153,280 (319)

Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages

Frontiers in Immunology, 2017
Tumor-associated macrophages (TAMs) frequently help to sustain tumor growth and mediate immune suppression in the tumor microenvironment (TME). Here, we identified a subset of iron-loaded, pro-inflammatory TAMs localized in hemorrhagic areas of the TME ...
Milene Costa da Silva, Milene Costa da Silva, Milene Costa da Silva, Milene Costa da Silva, Milene Costa da Silva, Michael O. Breckwoldt, Michael O. Breckwoldt, Francesca Vinchi, Francesca Vinchi, Margareta P. Correia, Ana Stojanovic, Carl Maximilian Thielmann, Carl Maximilian Thielmann, Michael Meister, Michael Meister, Thomas Muley, Thomas Muley, Arne Warth, Arne Warth, Michael Platten, Michael Platten, Matthias W. Hentze, Adelheid Cerwenka, Adelheid Cerwenka, Martina U. Muckenthaler, Martina U. Muckenthaler, Martina U. Muckenthaler   +26 more
doaj   +1 more source

Second order estimates for Hessian equations of parabolic type on Riemannian manifolds [PDF]

arXiv, 2015
In this paper, we establish the second order estimates of solutions to the first initial-boundary value problem for general Hessian type fully nonlinear parabolic equations on Riemannian manifolds. The techniques used in this article can work for a wide range of fully nonlinear PDEs under very general conditions.
arxiv  

Mannose‐Glycated Metal‐Phenolic Microcapsules Orchestrate Phenotype Switch of Macrophages for Boosting Tumor Immunotherapy

Advanced Science, EarlyView.
Immunomodulatory metal‐phenolic microcapsules (mMPMs) is developed in this study that leverages dopamine‐modified hyaluronic acid and FeIII assemble on mannose‐glycated bovine serum albumin microbubbles. mMPMs effectively promote macrophage internalization and M1 polarization, enhancing pro‐inflammatory responses.
Xin Tan, Renwang Sheng, Weikun Li, Yinghua Tao, Zonghao Liu, Ning Yang, Syeda Safia Hashmi, Feiling Feng, Fangzhou Liu, Liqin Ge   +9 more
wiley   +1 more source

Enabling Aromatic Hydroxylation in a Cytochrome P450 Monooxygenase Enzyme through Protein Engineering

Chemistry – A European Journal, Volume 28, Issue 67, December 1, 2022., 2022
Structural and biochemical data demonstrate that 4‐phenylbenzoic acid binds within the active site of the cytochrome P450 monooxygenase CYP199A4, but no oxidation occurs. Protein engineering and molecular dynamic simulations establish that aromatic oxidation is enabled by a subtle shift of the substrate relative to the heme, thus improving our ...
Tom Coleman, Joel Z. H. Lee, Alicia M. Kirk, Daniel Z. Doherty, Matthew N. Podgorski, Dilshi K. Pinidiya, John B. Bruning, James J. De Voss, Elizabeth H. Krenske, Stephen G. Bell   +9 more
wiley   +1 more source

The first initial boundary value problem for Hessian equations of parabolic type on Riemannian manifolds [PDF]

arXiv, 2015
In this paper, we are concerned with the first initial boundary value problem for a class of fully nonlinear parabolic equations on Riemannian manifolds. As usual, the establishment of the a priori C^2 estimates is our main part. Based on these estimates, the existence of classical solutions is proved under conditions which are nearly optimal.
arxiv  

Structural and Biochemical Characterization of a Widespread Enterobacterial Peroxidase Encapsulin

Advanced Science, EarlyView.
Encapsulins are self‐assembling bacterial protein compartments loaded with cargo enzymes. The most abundant encapsulin cargo class are Dye‐decolorizing Peroxidases (DyPs). In this study, we structurally and biochemically characterize a DyP encapsulin found in many enterobacteria.
Natalia C. Ubilla‐Rodriguez, Michael P. Andreas, Tobias W. Giessen   +2 more
wiley   +1 more source

Metformin Affects Heme Function as a Possible Mechanism of Action

G3: Genes, Genomes, Genetics, 2019
Metformin elicits pleiotropic effects that are beneficial for treating diabetes, as well as particular cancers and aging. In spite of its importance, a convincing and unifying mechanism to explain how metformin operates is lacking.
Xiyan Li, Xin Wang, Michael P. Snyder
doaj   +1 more source

Lipid Droplets Metabolism Mediated by ANXA7‐PPARγ Signaling Axis Regulates Spinal Cord Injury Repair in Mice

Advanced Science, EarlyView.
This work proposes a new mechanism for the regulation of LDs metabolism by ANXA7/PPARγ. ANXA7 can interact with PPARγ to promote its stability. ANXA7 activation promotes PPARγ nuclear translocation, thus promoting LDs formation and interaction with mitochondria by promoting PLIN5 expression.
Lu Chen, Haoran Liu, Linlin Jiang, Zihang Wang, Yong Chang, Na Li, Shiqing Feng   +6 more
wiley   +1 more source

CO‐Releasing Polyoxometalates Nanozyme with Gut Mucosal Immunity and Microbiota Homeostasis Remodeling Effects for Restoring Intestinal Barrier Integrity

Advanced Science, EarlyView.
A CO‐releasing polyoxometalates nanozyme (PMC) is engineered by coordinating pentacarbonyl manganese bromide with molybdenum‐based polyoxometalates nanoclusters. PMC exhibits targeted accumulation at IBD sites, efficient ROS scavenging, and responsive CO release.
Hongyang Lu, Qiang Zhou, Jiayu Li, Shengming Xu, Li Yu, Yinci Zhu, He Zhang, Chengge Shi, Tianci Zuo, Mengzhu Xu, Mingli Su, Yanmei Zhang, Rongdang Hu, Quazi T. H. Shubhra, Hui Deng, Xiaowen Hu, Xiaojun Cai   +16 more
wiley   +1 more source

Spin-filtering and Disorder Induced Giant Magnetoresistance in Carbon Nanotubes: Ab Initio Calculations [PDF]

, 2011
Nitrogen-doped carbon nanotubes can provide reactive sites on the porphyrin-like defects. It's well known that many porphyrins have transition metal atoms, and we have explored transition metal atoms bonded to those porphyrin-like defects in N-doped carbon nanotubes.
arxiv   +1 more source