Results 81 to 90 of about 232,755 (310)

Handling heme: The mechanisms underlying the movement of heme within and between cells

Free Radical Biology & Medicine, 2018
Heme is an essential cofactor and signaling molecule required for virtually all aerobic life. However, excess heme is cytotoxic. Therefore, heme must be safely transported and trafficked from the site of synthesis in the mitochondria or uptake at the ...
Rebecca K. Donegan, Courtney M. Moore, David A. Hanna, Amit R. Reddi   +3 more
semanticscholar   +1 more source

Heme carrier protein 1 transports heme and is involved in heme-Fe metabolism

American Journal of Physiology-Cell Physiology, 2012
Heme-Fe is an important source of dietary iron in humans; however, the mechanism for heme-Fe uptake by enterocytes is poorly understood. Heme carrier protein 1 (HCP1) was originally identified as mediating heme-Fe transport although it later emerged that it was a folate transporter.
Le Blanc, Solange, Garrick, Michael D., Arredondo, Miguel   +2 more
openaire   +4 more sources

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Heme and hemoglobin utilization by Mycobacterium tuberculosis

Nature Communications, 2019
Iron is essential for growth of Mycobacterium tuberculosis (Mtb), but most iron in the human body is stored in heme within hemoglobin. Here, we demonstrate that the substrate-binding protein DppA of the inner membrane Dpp transporter is required for heme
Avishek Mitra, Y. Ko, G. Cingolani, M. Niederweis   +3 more
semanticscholar   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Silencing of Iron and Heme-Related Genes Revealed a Paramount Role of Iron in the Physiology of the Hematophagous Vector Rhodnius prolixus

Frontiers in Genetics, 2018
Iron is an essential element for most organisms However, free iron and heme, its complex with protoporphyrin IX, can be extremely cytotoxic, due to the production of reactive oxygen species, eventually leading to oxidative stress.
Ana B. Walter-Nuno, Ana B. Walter-Nuno, Mabel L. Taracena, Mabel L. Taracena, Rafael D. Mesquita, Rafael D. Mesquita, Pedro L. Oliveira, Pedro L. Oliveira, Gabriela O. Paiva-Silva, Gabriela O. Paiva-Silva   +9 more
doaj   +1 more source

Natural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean

Advanced Science, EarlyView.
This study identified NAR5, a gene encoding a subtilisin‐like protease, that regulates nitrogenase activity in soybean nodules. Overexpressing NAR5 delayed nodule senescence, enhancing nitrogenase activity, yield, and low‐nitrogen tolerance. The elite haplotype NAR5HapI‐1 linked to superior nitrogenase activity and greater seed weight has been ...
Chao Ma, Hanyu Zhao, Haojie Feng, Xulun Dong, Lin Chen, Mingliang Yang, Runyi Chen, Chengjun Lei, Chunyan Liu, Qingshan Chen, Dawei Xin, Jinhui Wang   +11 more
wiley   +1 more source

Dietary Heme Induces Gut Dysbiosis, Aggravates Colitis, and Potentiates the Development of Adenomas in Mice

Frontiers in Microbiology, 2017
Dietary heme can be used by colonic bacteria equipped with heme-uptake systems as a growth factor and thereby impact on the microbial community structure.
M. Constante, G. Fragoso, A. Calvé, Macha Samba-Mondonga, Manuela M. Santos   +4 more
semanticscholar   +1 more source

hemes (heme derivatives)

, 2014
Citation: 'hemes (heme derivatives)' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.H02773 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for
openaire   +1 more source