Results 61 to 70 of about 187,269 (312)
Red meat and colon cancer : should we become vegetarians, or can we make meat safer ? [PDF]
, 2011 The effect of meat consumption on cancer risk is a controversial issue. However, recent meta-analyses show that high consumers of cured meats and red meat are at increased risk of colorectal cancer.
Denis E. Corpet +2 more
core +1 more source
Role of a secondary coordination sphere residue in halogenation catalysis of non-heme iron enzymes [PDF]
, 2022 Chemo- and regio-selective catalysis of C(sp3)-H halogenation reaction is a formidable goal in chemical synthesis. 2-oxo-glutarate (2OG) dependent non-heme iron halogenases catalyze selective chlorination/bromination of C-H bonds and exhibit high ...
Sourav, Chatterjee +4 more
core +1 more source
Foods, 2023 There is a growing demand for clean-label products. This study aimed to obtain a food-grade coloring ingredient for meat products based on the formation of Zn-protoporphyrin from porcine livers, thus contributing to the development of nitrite-free ...
Mar Llauger +5 more
doaj +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Creation of novel pharmacological tools in heme oxygenase research [PDF]
, 2012 Aims: While great strides have been made in the elucidation of the physiological and pharmacological roles of heme oxygenases (HO) in experimental animals and humans, there is still an enormous potential for further research discoveries and their ...
Vukomanovic, Dragic +11 more
core
Phototriggering Nitric Oxide Synthase from Geobacillus stearothermophilus [PDF]
, 2012 Nitric oxide synthases (NOS) produce L-citrulline and nitric oxide (NO) in two turnovers from L-arginine via the bound intermediate, N-hydroxy-L-arginine.
Keller, Gretchen Eva +1 more
core +1 more source
A Comparison of Pathophysiology in Humans and Rodent Models of Subarachnoid Hemorrhage
Frontiers in Molecular Neuroscience, 2018 Non-traumatic subarachnoid hemorrhage (SAH) affects an estimated 30,000 people each year in the United States, with an overall mortality of ~30%. Most cases of SAH result from a ruptured intracranial aneurysm, require long hospital stays, and result in ...
Jenna L. Leclerc +10 more
doaj +1 more source
Heme and immunity: The heme oxygenase dichotomy
Journal of Inorganic BiochemistryHeme, an iron containing organic ring, is required for a diverse range of biological processes across all forms of life. Although this nutrient is essential, its pro-inflammatory and cytotoxic properties can lead to cellular damage. Heme oxygenase 1 (HO-1) is an endoplasmic reticulum (ER)-anchored enzyme that degrades heme, releasing equimolar amounts ...
Perry, Melissa, Hamza, Iqbal
openaire +2 more sources
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Altered heme catabolism by heme oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductase [PDF]
, 2010 Human heme oxygenase-1 (HO-1) carries out heme catabolism supported by electrons supplied from the NADPH through NADPH P450 reductase (POR, CPR). Previously we have shown that mutations in human POR cause a rare form of congenital adrenal hyperplasia. In
Primus E. Mullis +5 more
core +1 more source