Results 61 to 70 of about 232,755 (310)

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Utilization of Porcine Livers through the Formation of Zn-Protoporphyrin Pigment Optimized by a Response Surface Methodology

Foods, 2023
There is a growing demand for clean-label products. This study aimed to obtain a food-grade coloring ingredient for meat products based on the formation of Zn-protoporphyrin from porcine livers, thus contributing to the development of nitrite-free ...
Mar Llauger, Jacint Arnau, Michela Albano-Gaglio, Sara Bover-Cid, Belén Martín, Ricard Bou   +5 more
doaj   +1 more source

Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles.

JCI Insight, 2018
In hemolytic diseases, such as sickle cell disease (SCD), intravascular hemolysis results in the release of hemoglobin, heme, and heme-loaded membrane microvesicles in the bloodstream.
N. Merle, Anne Grunenwald, Helena Rajaratnam, V. Gnemmi, Marie Frimat, Marie-Lucile Figueres, Samantha Knockaert, Sanah Bouzekri, D. Charue, Rémi Noé, Tania Robe-Rybkine, Marie Le-Hoang, Nathan Brinkman, T. Gentinetta, M. Edler, S. Petrillo, E. Tolosano, S. Miescher, Sylvain Le Jeune, P. Houillier, S. Chauvet, M. Rabant, J. Dimitrov, V. Frémeaux-Bacchi, O. Blanc-Brude, L. Roumenina   +25 more
semanticscholar   +1 more source

Heme and immunity: The heme oxygenase dichotomy

Journal of Inorganic Biochemistry
Heme, an iron containing organic ring, is required for a diverse range of biological processes across all forms of life. Although this nutrient is essential, its pro-inflammatory and cytotoxic properties can lead to cellular damage. Heme oxygenase 1 (HO-1) is an endoplasmic reticulum (ER)-anchored enzyme that degrades heme, releasing equimolar amounts ...
Perry, Melissa, Hamza, Iqbal
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A Comparison of Pathophysiology in Humans and Rodent Models of Subarachnoid Hemorrhage

Frontiers in Molecular Neuroscience, 2018
Non-traumatic subarachnoid hemorrhage (SAH) affects an estimated 30,000 people each year in the United States, with an overall mortality of ~30%. Most cases of SAH result from a ruptured intracranial aneurysm, require long hospital stays, and result in ...
Jenna L. Leclerc, Jenna L. Leclerc, Joshua M. Garcia, Matthew A. Diller, Anne-Marie Carpenter, Pradip K. Kamat, Brian L. Hoh, Brian L. Hoh, Sylvain Doré, Sylvain Doré, Sylvain Doré   +10 more
doaj   +1 more source

Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways

Antioxidants, 2019
The heme oxygenase (HO) system is essential for heme and iron homeostasis and necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon monoxide (CO) and ferrous iron.
J. Duvigneau, H. Esterbauer, Andrey V. Kozlov   +2 more
semanticscholar   +1 more source

Heme Sensor Proteins [PDF]

Journal of Biological Chemistry, 2013
Heme is a prosthetic group best known for roles in oxygen transport, oxidative catalysis, and respiratory electron transport. Recent years have seen the roles of heme extended to sensors of gases such as O2 and NO and cell redox state, and as mediators of cellular responses to changes in intracellular levels of these gases.
Girvan, Hazel M., Munro, Andrew W.
openaire   +2 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

A conserved two-component system senses intracellular iron levels and regulates redox balance in Mycobacterium spp.

Microbiology Spectrum
For bacteria, an intricate coordination between sensing and regulating iron levels and managing oxidative stress is required as their levels are tightly interlinked.
Rahul Yadav, Deepak Kumar Saini
doaj   +1 more source