Results 51 to 60 of about 187,269 (312)

Heme Oxygenase Protects against Placental Vascular Inflammation and Abortion by the Alarmin Heme in Mice. [PDF]

, 2020
Both infectious as non-infectious inflammation can cause placental dysfunction and pregnancy complications. During the first trimester of human gestation, when palatogenesis takes place, intrauterine hematoma and hemorrhage are common phenomena, causing ...
Christiaan M. Suttorp, Suttorp, Christiaan M, van Rheden, Rene E. M., Suttorp, Christiaan M., Kuijpers-Jagtman, Anne Marie; id_orcid, Helmich, M.P.A.C., van Dijk, Natasja W. M., René E. M. van Rheden, Helmich, Maria P. A. C., Wagener, F.A.D.T.G., Rheden, R.E.M. van, Dijk, N.W.M. van, Wagener, Frank A D T G, Anne Marie Kuijpers-Jagtman, Frank A. D. T. G. Wagener, Wagener, Frank A. D. T. G., Helmich, Maria P A C, Kuijpers-Jagtman, Anne Marie, Maria P. A. C. Helmich, van Rheden, René E M, van Dijk, Natasja W M, Suttorp, C.M., Kuijpers-Jagtman, A.M., Natasja W. M. van Dijk   +23 more
core   +1 more source

Effects of Bodypump Training on Blood Pressure and Physical Fitness in Sedentary Older Adults with Hypertension: A Randomized Trial

Physiologia
Background/Objectives: Hypertension is a leading cause of cardiovascular morbidity and mortality, particularly in older adults, pharmacological therapy is effective, but side effects and limited adherence highlight the need for non-pharmacological ...
Manuel Jesús Rodríguez Chavarría, Manuel Chavarrías-Olmedo, Jorge Pérez-Gómez   +2 more
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

How iron is handled in the course of heme catabolism: Integration of heme oxygenase with intracellular iron transport mechanisms mediated by poly (rC)-binding protein-2 [PDF]

, 2019
Heme and iron are essential to almost all forms of life. The strict maintenance of heme and iron homeostasis is essential to prevent cellular toxicity and the existence of systemic and intracellular regulation is fundamental.
Kishi, Fumio, Yanatori, Izumi, Richardson, Des R, Toyokuni, Shinya   +3 more
core   +1 more source

Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

Cell Reports, 2020
Summary: Hemopexin (Hx) is a scavenger of labile heme. Herein, we present data defining the role of tumor stroma-expressed Hx in suppressing cancer progression.
Giacomo Canesin, Annalisa Di Ruscio, Mailin Li, Simone Ummarino, Andreas Hedblom, Reeham Choudhury, Agnieszka Krzyzanowska, Eva Csizmadia, Macarena Palominos, Anna Stiehm, Alexander Ebralidze, Shao-Yong Chen, Mahmoud A. Bassal, Ping Zhao, Emanuela Tolosano, Laurence Hurley, Anders Bjartell, Daniel G. Tenen, Barbara Wegiel   +18 more
doaj   +1 more source

Bio-Electroanalysis Performance of Heme Redox-Center for π-π Interaction Bonding of a Methylene Blue-Graphene Modified Electrode

Nanomaterials, 2023
Hemeprotein detection has motivated extensive research on the direct reaction of a heme molecule and a redox dye. The present study used methylene blue as both donor and acceptor for a redox reaction.
Porntip Khownarumit, Kanmanee Choosang, Rungtiva P. Poo-arporn, Yingyot Poo-arporn, Narong Chanlek, Werasak Surareungchai   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Bacterial Myeloperoxidase with Antimicrobial Properties

BioTech, 2023
The four mammalian peroxidases (myeloperoxidase, eosinophilperoxidase, lactoperoxidase, and thyroid peroxidase) are widely studied in the literature. They catalyze the formation of antimicrobial compounds and participate in innate immunity.
Claire Céré, Brigitte Delord, Parfait Kenfack Ymbe, Léa Vimbert, Jean-Paul Chapel, Claire Stines-Chaumeil   +5 more
doaj   +1 more source

Heme b (protoheme IX) is a precursor of heme a and heme d in Bacillus subtilis [PDF]

FEMS Microbiology Letters, 1993
Bacillus subtilis can synthesise cytochromes containing a-, b-, c- and d-type heme. The biosynthetic pathways of these heme prosthetic groups were investigated by using strains blocked in uroporphyrinogen III synthesis from porphobilinogen or in heme b (protoheme IX) synthesis from uroporphyrinogen III. The results strongly suggest that heme a and heme
M, Hansson, C, von Wachenfeldt
openaire   +2 more sources

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source