Results 51 to 60 of about 207,281 (307)

Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

Cell Reports, 2020
Summary: Hemopexin (Hx) is a scavenger of labile heme. Herein, we present data defining the role of tumor stroma-expressed Hx in suppressing cancer progression.
Giacomo Canesin, Annalisa Di Ruscio, Mailin Li, Simone Ummarino, Andreas Hedblom, Reeham Choudhury, Agnieszka Krzyzanowska, Eva Csizmadia, Macarena Palominos, Anna Stiehm, Alexander Ebralidze, Shao-Yong Chen, Mahmoud A. Bassal, Ping Zhao, Emanuela Tolosano, Laurence Hurley, Anders Bjartell, Daniel G. Tenen, Barbara Wegiel   +18 more
doaj   +1 more source

Bio-Electroanalysis Performance of Heme Redox-Center for π-π Interaction Bonding of a Methylene Blue-Graphene Modified Electrode

Nanomaterials, 2023
Hemeprotein detection has motivated extensive research on the direct reaction of a heme molecule and a redox dye. The present study used methylene blue as both donor and acceptor for a redox reaction.
Porntip Khownarumit, Kanmanee Choosang, Rungtiva P. Poo-arporn, Yingyot Poo-arporn, Narong Chanlek, Werasak Surareungchai   +5 more
doaj   +1 more source

Genetic variants of the promoter of the heme oxygenase-1 gene and their influence on cardiovascular disease (The Ludwigshafen risk and cardiovascular health study) [PDF]

, 2009
Background Heme oxygenase-1 is an inducible cytoprotective enzyme which handles oxidative stress by generating anti-oxidant bilirubin and vasodilating carbon monoxide.
Hoffmann Michael M, Hoffmann, Michael Marcus, März Winfried, Boehm Bernhard O, Wellnitz Britta, Karl Winkler, Bernhard O Boehm, Bernhard R Winkelmann, März, Winfried, Winkelmann Bernhard R, Winkler Karl, Hoffmann, Michael M., Seelhorst Ursula, Ursula Seelhorst, Seelhorst, Ursula, Britta Wellnitz, Böhm, Bernhard O., Böhm, Bernhard Otto, Michael M Hoffmann, Lüblinghoff Nicola, Lüblinghoff, Nicola, Winkelmann, Bernhard Rudolf, Winfried März, Winkler, Karl, Nicola Lüblinghoff, Winkelmann, Bernhard R., Wellnitz, Britta   +26 more
core   +2 more sources

Iron, heme, and nitrosyl-heme content in Spanish meat derivatives [PDF]

, 2023
Heme and nitrosyl-heme have been pointed out as responsible for the association between processed meats and cancer. The objective of this study was to obtain reliable data on the current proximate composition, total iron, total heme, zinc-protoporphyrin,
Bou, Ricard, Sabeña, Gerard, Farran-Codina, Andreu, Rizzolo-Brime, Lucía, Arnau, Jacint, Jakszyn, Paula   +5 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A Bacterial Myeloperoxidase with Antimicrobial Properties

BioTech, 2023
The four mammalian peroxidases (myeloperoxidase, eosinophilperoxidase, lactoperoxidase, and thyroid peroxidase) are widely studied in the literature. They catalyze the formation of antimicrobial compounds and participate in innate immunity.
Claire Céré, Brigitte Delord, Parfait Kenfack Ymbe, Léa Vimbert, Jean-Paul Chapel, Claire Stines-Chaumeil   +5 more
doaj   +1 more source

Utilization of Porcine Livers through the Formation of Zn-Protoporphyrin Pigment Optimized by a Response Surface Methodology

Foods, 2023
There is a growing demand for clean-label products. This study aimed to obtain a food-grade coloring ingredient for meat products based on the formation of Zn-protoporphyrin from porcine livers, thus contributing to the development of nitrite-free ...
Mar Llauger, Jacint Arnau, Michela Albano-Gaglio, Sara Bover-Cid, Belén Martín, Ricard Bou   +5 more
doaj   +1 more source

Heme b (protoheme IX) is a precursor of heme a and heme d in Bacillus subtilis [PDF]

FEMS Microbiology Letters, 1993
Bacillus subtilis can synthesise cytochromes containing a-, b-, c- and d-type heme. The biosynthetic pathways of these heme prosthetic groups were investigated by using strains blocked in uroporphyrinogen III synthesis from porphobilinogen or in heme b (protoheme IX) synthesis from uroporphyrinogen III. The results strongly suggest that heme a and heme
M, Hansson, C, von Wachenfeldt
openaire   +2 more sources

Heme-dependent decreases in endothelial barrier resistance are TLR4-dependent.

, 2018
Rat microvascular endothelial cell (RMVEC) monolayers were seeded in Electric Cell-substrate Impedance Sensing (ECIS) arrays as described in Methods. When monolayers reached the appropriate resistance, monolayers were treated with vehicle or heme (10 μM,
Jean-Francois Pittet (254567), Angela P. Brandon (4925758), Rakesh P. Patel (308052), Shannon W. Stephens (4925773), Judy Creighton (4925776), Marisa B. Marques (721880), Jillian R. Richter (4925779), Brant M. Wagener (586587), Jeffrey D. Kerby (4925770), Cilina A. Evans (4925767), Parker J. Hu (4925764), Charity Morgan (4925761), Jaideep Honavar (412428), Joo-Yeun Oh (704641), Randal O. Dull (829904)   +14 more
core   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source