Results 31 to 40 of about 207,281 (307)

Creation of novel pharmacological tools in heme oxygenase research [PDF]

, 2012
Aims: While great strides have been made in the elucidation of the physiological and pharmacological roles of heme oxygenases (HO) in experimental animals and humans, there is still an enormous potential for further research discoveries and their ...
Vukomanovic, Dragic, Hum, Maaike, Rahman, Mona N., McLaughlin, Brian E., Dercho , Ryan, Brien, James F., Vlahakis, Jason Z., Jia, Zongchao, Kinobe, Robert T., Szarek, Walter A., Roman, Gheorghe, Nakatsu, Kanji   +11 more
core   +2 more sources

The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression

mSphere, 2023
Pseudomonas aeruginosa is an opportunistic pathogen that requires iron for growth and virulence, yet this nutrient is sequestered by the innate immune system during infection. When iron is limiting, P. aeruginosa expresses the PrrF1 and PrrF2 small RNAs (
Tra-My Hoang, Weiliang Huang, Jonathan Gans, Jacob Weiner, Evan Nowak, Mariette Barbier, Angela Wilks, Maureen A. Kane, Amanda G. Oglesby   +8 more
doaj   +1 more source

Heme Oxygenase-2 Is a Hemoprotein and Binds Heme through Heme Regulatory Motifs That Are Not Involved in Heme Catalysis [PDF]

Journal of Biological Chemistry, 1997
The heme oxygenase (HO) system degrades heme to biliverdin and CO and releases chelated iron. In the primary sequence of the constitutive form, HO-2, there are three potential heme binding sites: two heme regulatory motifs (HRMs) with the absolutely conserved Cys-Pro pair, and a conserved 24-residue heme catalytic pocket with a histidine residue ...
W K, McCoubrey, T J, Huang, M D, Maines
openaire   +2 more sources

Heme Oxygenase Protects against Placental Vascular Inflammation and Abortion by the Alarmin Heme in Mice. [PDF]

, 2020
Both infectious as non-infectious inflammation can cause placental dysfunction and pregnancy complications. During the first trimester of human gestation, when palatogenesis takes place, intrauterine hematoma and hemorrhage are common phenomena, causing ...
Christiaan M. Suttorp, Suttorp, Christiaan M, van Rheden, Rene E. M., Suttorp, Christiaan M., Kuijpers-Jagtman, Anne Marie; id_orcid, Helmich, M.P.A.C., van Dijk, Natasja W. M., René E. M. van Rheden, Helmich, Maria P. A. C., Wagener, F.A.D.T.G., Rheden, R.E.M. van, Dijk, N.W.M. van, Wagener, Frank A D T G, Anne Marie Kuijpers-Jagtman, Frank A. D. T. G. Wagener, Wagener, Frank A. D. T. G., Helmich, Maria P A C, Kuijpers-Jagtman, Anne Marie, Maria P. A. C. Helmich, van Rheden, René E M, van Dijk, Natasja W M, Suttorp, C.M., Kuijpers-Jagtman, A.M., Natasja W. M. van Dijk   +23 more
core   +2 more sources

Free Rather Than Total Iron Content Is Critically Linked to the Fur Physiology in Shewanella oneidensis

Frontiers in Microbiology, 2020
Ferric uptake regulator (Fur) is a transcriptional regulator playing a central role in iron homeostasis of many bacteria, and Fur inactivation commonly results in pleiotropic phenotypes.
Lulu Liu, Xue Feng, Wei Wang, Yining Chen, Zhe Chen, Haichun Gao   +5 more
doaj   +1 more source

Heme-Induced Biomarkers Associated with Red Meat Promotion of colon Cancer Are Not Modulated by the Intake of Nitrite [PDF]

, 2013
Red and processed meat consumption is associated with the risk of colorectal cancer. Three hypotheses are proposed to explain this association, via heme-induced oxidation of fat, heterocyclic amines, or N-nitroso compounds.
Tache, Sylvaine, Kunhle, Gunter G C, Taché, Sylviane, Pierre, Fabrice H., Kunhle, Gunter G.C., Corpet, Dennis E., Kunhle, Gunter G. C., Chenni, Fatima Z, Hobbs, Ditte A, Pierre, Fabrice, Kuhnle, Gunter G. C., Hobbs, Ditte A., Naud, Nathalie, Pierre, Fabrice H.F., Guéraud, Françoise, Chenni, Fatima Z., Corpet, Denis E.   +16 more
core   +1 more source

Biochemical and Biophysical Studies of Heme Binding Proteins from the Corynebacterium diphtheriae and Streptococcus pyogenes Heme Uptake Pathways

, 2018
The Gram-positive pathogens Corynebacterium diphtheriae and Streptococcus pyogenes both require iron for survival. These bacteria have developed sophisticated heme uptake and transport protein machinery responsible for the import of iron into the cell ...
Draganova, Elizabeth B
core   +1 more source

Identification of Heme Binding Loci using Heme-Seq [PDF]

, 2021
G-quadruplexes, a type of nucleic acid secondary structure consisting largely of folded quartets of guanines, appear to play a regulatory role in the human genome. Heme has been shown to interact with G-quadruplexes.
Mukerjee, Joshua, 0000-0002-5010-1913
core   +1 more source

Maturation of Plastid c-type Cytochromes

Frontiers in Plant Science, 2017
Cytochromes c are hemoproteins, with the prosthetic group covalently linked to the apoprotein, which function as electron carriers. A class of cytochromes c is defined by a CXXCH heme-binding motif where the cysteines form thioether bonds with the vinyl ...
Stéphane T. Gabilly, Stéphane T. Gabilly, Patrice P. Hamel, Patrice P. Hamel   +3 more
doaj   +1 more source

Endothelial TLR4 Expression Mediates Vaso-Occlusive Crisis in Sickle Cell Disease

Frontiers in Immunology, 2021
Heme, released from red blood cells in sickle cell disease (SCD), interacts with toll-like receptor 4 (TLR4) to activate NF-κB leading to the production of cytokines and adhesion molecules which promote inflammation, pain, and vaso-occlusion.
Joan D. Beckman, Fuad Abdullah, Chunsheng Chen, Rachel Kirchner, Dormarie Rivera-Rodriguez, Zachary M. Kiser, Aithanh Nguyen, Ping Zhang, Julia Nguyen, Robert P. Hebbel, John D. Belcher, Gregory M. Vercellotti   +11 more
doaj   +1 more source