Results 21 to 30 of about 232,755 (310)

Excess Heme Promotes the Migration and Infiltration of Macrophages in Endometrial Hyperplasia Complicated with Abnormal Uterine Bleeding

Biomolecules, 2022
In patients, endometrial hyperplasia (EH) is often accompanied by abnormal uterine bleeding (AUB), which is prone to release large amounts of heme. However, the role of excess heme in the migration and infiltration of immune cells in EH complicated by ...
Lu-Yu Ruan, Zhen-Zhen Lai, Jia-Wei Shi, Hui-Li Yang, Jiang-Feng Ye, Feng Xie, Xue-Min Qiu, Xiao-Yong Zhu, Ming-Qing Li   +8 more
doaj   +1 more source

Hsp90 in Human Diseases: Molecular Mechanisms to Therapeutic Approaches

Cells, 2022
The maturation of hemeprotein dictates that they incorporate heme and become active, but knowledge of this essential cellular process remains incomplete. Studies on chaperon Hsp90 has revealed that it drives functional heme maturation of inducible nitric
Mamta P. Sumi, Arnab Ghosh
doaj   +1 more source

NEAr Transporter (NEAT) Domains: Unique Surface Displayed Heme Chaperones That Enable Gram-Positive Bacteria to Capture Heme-Iron From Hemoglobin

Frontiers in Microbiology, 2021
Iron is an important micronutrient that is required by bacteria to proliferate and to cause disease. Many bacterial pathogens forage iron from human hemoglobin (Hb) during infections, which contains this metal within heme (iron–protoporphyrin IX ...
Ken Ellis-Guardiola, Ken Ellis-Guardiola, Brendan J. Mahoney, Brendan J. Mahoney, Robert T. Clubb, Robert T. Clubb, Robert T. Clubb   +6 more
doaj   +1 more source

COVID-19:Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism

, 2020
The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory caused by the novel coronavirus. The virus is the positive-strand RNA one with high homology to bat coronavirus.
Wenzhong Liu, Hualan Li
semanticscholar   +1 more source

Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation

Frontiers in Cell and Developmental Biology, 2021
Augmenter of liver regeneration (ALR) is a critical multi-isoform protein with its longer isoform, located in the mitochondrial intermembrane space, being part of the mitochondrial disulfide relay system (DRS).
Yaschar Kabiri, Anna Fuhrmann, Anna Becker, Luisa Jedermann, Carola Eberhagen, Ann-Christine König, Tiago Barros Silva, Fernanda Borges, Stefanie M. Hauck, Bernhard Michalke, Percy Knolle, Hans Zischka, Hans Zischka   +12 more
doaj   +1 more source

Pro-inflammatory Actions of Heme and Other Hemoglobin-Derived DAMPs

Frontiers in Immunology, 2020
Damage associated molecular patterns (DAMPs) are endogenous molecules originate from damaged cells and tissues with the ability to trigger and/or modify innate immune responses.
M. Bozza, V. Jeney
semanticscholar   +1 more source

Analyzing magnetic bead QuantiGene® Plex 2.0 gene expression data in high throughput mode using QGprofiler

BMC Bioinformatics, 2019
Background The QuantiGene® Plex 2.0 platform (ThermoFisher Scientific) combines bDNA with the Luminex/xMAP magnetic bead capturing technology to assess differential gene expression in a compound exposure setting.
Bie Verbist, Eva Adriaensen, Vikki Keersmaekers, Dea Putri, Marjolein Crabbe, Maarten Derks, Rytis Bagdziunas, Griet Laenen, Hans De Wolf   +8 more
doaj   +1 more source

Involvement of Small Colony Variant-Related Heme Biosynthesis Genes in Staphylococcus aureus Persister Formation in vitro

Frontiers in Microbiology, 2021
Background: Persisters are important reasons for persistent infections, and they can lead to antibiotic treatment failure in patients and consequently chronic infection.
Xuyang Wang, Weizheng Li, Wenjie Wang, Shiyong Wang, Tao Xu, Jiazhen Chen, Wenhong Zhang, Wenhong Zhang, Wenhong Zhang   +8 more
doaj   +1 more source

Peroxidase activity of erythrocytes hemoglobin under action of low-frequency vibration

Біологічні студії, 2021
Background. Hemoglobin is a hemoprotein which in the presence of oxidative equivalents, such as H2O2, can act as peroxidase with a very high oxidative potential.
O. I. Dotsenko, G. V. Taradina, А. М. Mischenko   +2 more
doaj   +1 more source

From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme

Cells, 2020
Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo ...
Samantha A. Swenson, Courtney M. Moore, J. R. Marcero, A. Medlock, Amit R. Reddi, O. Khalimonchuk   +5 more
semanticscholar   +1 more source