Tracking hemopexin intracellularly and defining hemopexin protein “interactomes” in human immune and liver cell models [PDF]
Frontiers in PhysiologyMaintaining hemopexin (HPX) plasma levels protects against heme-activated inflammation as well as the toxicity of heme and its iron during hemolysis. Plasma heme regulates HPX turnover in hepatocytes, thus controlling plasma HPX concentration.
Bryan Rose +7 more
doaj +4 more sources
Hemopexin and HO-1 induction during acute colitis in mice is dependent on interleukin-22 [PDF]
Frontiers in ImmunologyIntroductionInflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract that frequently requires long-term immunosuppressive therapy, which increases the risk of infections and other complications.
Ayodeji Samuel Ajayi +5 more
doaj +2 more sources
Hemopexin as an Inhibitor of Hemolysis-Induced Complement Activation
Frontiers in Immunology, 2020 Hemopexin is the main plasmatic scavenger of cell-free heme, released in the context of intravascular hemolysis or major cell injury. Heme is indispensable for the oxygen transport by hemoglobin but when released outside of the erythrocytes it becomes a ...
Juliette Leon +2 more
exaly +3 more sources
The association of hemopexin, muscle quality, and sarcopenia in Japanese older adults with cognitive impairment: a cross-sectional study [PDF]
BMC GeriatricsObjective To examine the cross-sectional associations of hemopexin, muscle quality, and sarcopenia status with cognitive function among older Japanese adults with cognitive impairment, and to explore the potential sex-specific differences.
Derong Zeng +7 more
doaj +2 more sources
Targeting HMGB1 in endothelial cells reverses heme-induced SIRS after radiofrequency ablation of hepatic hemangioma [PDF]
Frontiers in ImmunologyBackgroundAlthough radiofrequency ablation (RFA) is a safe and effective treatment for hepatic hemangiomas, post-RFA systemic inflammatory response syndrome (SIRS) frequently occurs.
Changyu Yao +9 more
doaj +2 more sources
Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases
Cell Reports, 2020 Summary: Hemopexin (Hx) is a scavenger of labile heme. Herein, we present data defining the role of tumor stroma-expressed Hx in suppressing cancer progression.
Simone Ummarino +2 more
exaly +3 more sources
Plasma heme pool compartmentalization is linked to pathophysiology in Sickle Cell Disease. [PDF]
PLoS ONEHeme toxicity plays a central role in the pathophysiology of Sickle Cell Disease (SCD), contributing to severe complications such as vaso-occlusion and acute chest syndrome.
Moritz Saxenhofer +29 more
doaj +2 more sources
Editorial: Heme physiology and pathology [PDF]
Frontiers in PhysiologyElena Di Pierro, Tiago L. Duarte
doaj +2 more sources
The heme scavenger hemopexin protects against lung injury during aspergillosis by mitigating release of neutrophil extracellular traps [PDF]
JCI InsightInvasive aspergillosis is characterized by lung hemorrhage and release of extracellular heme, which promotes fungal growth. Heme can also mediate tissue injury directly, and both fungal growth and lung injury may induce hemorrhage.
Ganlin Qu +9 more
doaj +2 more sources
PLoS ONE, 2020 Hemopexin and α1-microglobulin act as scavengers to eliminate free heme-groups responsible for hemoglobin-induced oxidative stress. The present study evaluated maternal and fetal plasma concentrations of these scavengers in the different phenotypes of ...
Lina Youssef +8 more
doaj +2 more sources