Results 31 to 40 of about 6,390 (173)
Frontiers in Molecular Biosciences, 2020 Brain iron dyshomeostasis is a feature of Alzheimer's disease. Conventionally, research has focused on non-heme iron although degradation of heme from hemoglobin subunits can generate iron to augment the redox-active iron pool.
Azhaar A. Ashraf +2 more
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Interactions of Porphyrins with Rabbit Hemopexin
Journal of Biological Chemistry, 1972 Abstract The formation of complexes of rabbit hemopexin with a representative group of porphyrins was investigated to determine the stoichiometry and estimated dissociation constants (Kd) as well as the effect of pH on these interactions. In a 1:1 molar ratio, rabbit apohemopexin (RHx) binds iron-protoporphyrin IX (heme), iron-deuteroporphyrin IX ...
W T, Morgan, U, Muller-Eberhard
openaire +2 more sources
Pharmaceuticals, 2019 This review provides a synopsis of the published literature over the past two years on the heme-binding protein hemopexin (HPX), with some background information on the biochemistry of the HPX system.
Luis Montecinos +2 more
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Free heme exacerbates colonic injury induced by anti-cancer therapy
Frontiers in Immunology, 2023 Gastrointestinal inflammation and bleeding are commonly induced by cancer radiotherapy and chemotherapy but mechanisms are unclear. We demonstrated an increased number of infiltrating heme oxygenase-1 positive (HO-1+) macrophages (Mø, CD68+) and the ...
Philippa Seika +12 more
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Molecules, 2022 Analysis of protein glycosylation is challenging due to micro- and macro-heterogeneity of the attached glycans. Hydrophilic interaction liquid chromatography (HILIC) is a mode of choice for separation of intact glycopeptides, which are inadequately ...
Petr Kozlik +4 more
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Frontiers in Immunology, 2022 Soil-transmitted helminth [mainly Strongyloidiasis stercoralis (Ss)] and tuberculous lymphadenitis (TBL) coinfection in humans is a significant public health problem. We have previously shown that TBL+Ss+ coinfection significantly alters diverse cytokine,
Gokul Raj Kathamuthu +6 more
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Data in Brief, 2022 Hemorrhagic stroke is a major cause of morbidity and mortality worldwide. Secondary mechanisms of brain injury adversely affect functional outcome in patients after intracranial hemorrhage.
Kevin Akeret +3 more
doaj +1 more source
Advanced Science, EarlyView.Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu +9 more
wiley +1 more source
Perinatal Metabolism of Hemopexin and Heme
Experimental Biology and Medicine, 1971 SummarySera from fetal, newborn, and juvenile rabbits were found to have lower Hx levels than those of their mothers but approached the normal adult range by 30 to 60 days of age. Inadequate materno-fetal transport of Hx contributed to low fetal and neonatal serum levels, since only small amounts of homologous 125I-Hx passed from the maternal ...
J D, Ross, H H, Liem, U, Muller-Eberhard
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Biotechnology and Bioengineering, EarlyView.ABSTRACT Hemopexin (Hpx) is an acute phase plasma protein that is responsible for sequestration and removal of cell‐free heme with very high affinity (Kd < 1 pM). Hpx expression in liver cells is induced following an inflammatory event such as severe hemolysis. Therefore, plasma Hpx has potential clinical relevance due to its' ability to bind free heme,
Shuwei Lu +8 more
wiley +1 more source