Results 31 to 40 of about 7,813 (203)

Stromal expression of hemopexin is associated with lymph-node metastasis in pancreatic ductal adenocarcinoma.

PLoS ONE, 2020
Pancreatic ductal adenocarcinoma is one of the most aggressive types of cancer. Certain proteins in the tumor microenvironment have attracted considerable attention owing to their association with tumor invasion and metastasis.
Yukie Suzuki, Tatsuyuki Takadate, Masamichi Mizuma, Hiroki Shima, Takashi Suzuki, Tomoyoshi Tachibana, Mitsuhiro Shimura, Tatsuo Hata, Masahiro Iseki, Kei Kawaguchi, Takeshi Aoki, Hiroki Hayashi, Takanori Morikawa, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Kazuhiko Igarashi, Michiaki Unno   +17 more
doaj   +1 more source

TLR4 Signaling by Heme and the Role of Heme-Binding Blood Proteins

Frontiers in Immunology, 2020
Toll-like receptors (TLRs), also known as pattern recognition receptors, respond to exogenous pathogens and to intrinsic danger signals released from damaged cells and tissues.
Sabina Janciauskiene, Vijith Vijayan, Stephan Immenschuh   +2 more
doaj   +1 more source

A Rapid LC-MS/MS-PRM Assay for Serologic Quantification of Sialylated O-HPX Glycoforms in Patients with Liver Fibrosis

Molecules, 2022
Development of high throughput robust methods is a prerequisite for a successful clinical use of LC-MS/MS assays. In earlier studies, we reported that nLC-MS/MS measurement of the O-glycoforms of HPX is an indicator of liver fibrosis.
Aswini Panigrahi, Julius Benicky, Renhuizi Wei, Jaeil Ahn, Radoslav Goldman, Miloslav Sanda   +5 more
doaj   +1 more source

Heme‐hemopexin: A ‘Chronosteric’ heme‐protein [PDF]

IUBMB Life, 2007
AbstractHemopexin (HPX) serves as scavenger and transporter of toxic plasma heme to the liver. HPX is formed by two four‐bladed β‐propeller domains, resembling two thick disks that lock together at a 90° angle. The heme is bound between the two β‐propeller domains in a pocket formed by the interdomain linker peptide.
ASCENZI P, FASANO, MAURO
openaire   +4 more sources

The Diversity of Mammalian Hemoproteins and Microbial Heme Scavengers Is Shaped by an Arms Race for Iron Piracy

Frontiers in Immunology, 2018
Iron is an essential micronutrient for most living species. In mammals, hemoglobin (Hb) stores more than two thirds of the body's iron content. In the bloodstream, haptoglobin (Hp) and hemopexin (Hpx) sequester free Hb or heme.
Alessandra Mozzi, Diego Forni, Mario Clerici, Mario Clerici, Rachele Cagliani, Manuela Sironi   +5 more
doaj   +1 more source

Vascular contraction and preeclampsia downregulation of the angiotensin receptor 1 by hemopexin in vitro [PDF]

, 2009
During normal pregnancy, in contrast to preeclampsia, plasma hemopexin activity is increased together with a decreased vascular angiotensin II receptor (AT1) expression.
Poelstra, Klaas, van Pampus, Maria, Navis, G., Borghuis, Theo, Bakker, W.W., van Goor, H., Jongman, R.M., Poelstra, Klaas; id_orcid, Borghuis, T., van Goor, Harry; id_orcid, Aarnoudse, Jan G., Niezen-Koning, Klary E.; id_orcid, van Son, W.J., Aarnoudse, J.G., van Pampus, M.G., van Son, Willem J., Niezen-Koning, K.E., Henning, R.H., Bakker, Winston W., Navis, Gerjan, van Goor, Harry, Henning, Rob H., Jongman, Rianne M., Niezen-Koning, Klary E., Poelstra, K., Faas, M.M., Faas, Marijke M.   +26 more
core   +2 more sources

Characterization of Renal Injury and Inflammation in an Experimental Model of Intravascular Hemolysis

Frontiers in Immunology, 2018
Intravascular erythrocyte destruction, accompanied by the release of pro-oxidative and pro-inflammatory components hemoglobin and heme, is a common event in the pathogenesis of numerous diseases with heterogeneous etiology and clinical features.
Nicolas S. Merle, Nicolas S. Merle, Nicolas S. Merle, Anne Grunenwald, Anne Grunenwald, Anne Grunenwald, Marie-Lucile Figueres, Marie-Lucile Figueres, Marie-Lucile Figueres, Sophie Chauvet, Sophie Chauvet, Sophie Chauvet, Sophie Chauvet, Marie Daugan, Marie Daugan, Marie Daugan, Samantha Knockaert, Samantha Knockaert, Samantha Knockaert, Tania Robe-Rybkine, Tania Robe-Rybkine, Tania Robe-Rybkine, Remi Noe, Remi Noe, Remi Noe, Olivia May, Olivia May, Olivia May, Marie Frimat, Marie Frimat, Nathan Brinkman, Thomas Gentinetta, Sylvia Miescher, Pascal Houillier, Pascal Houillier, Pascal Houillier, Veronique Legros, Florence Gonnet, Olivier P. Blanc-Brude, Olivier P. Blanc-Brude, Marion Rabant, Regis Daniel, Jordan D. Dimitrov, Jordan D. Dimitrov, Jordan D. Dimitrov, Lubka T. Roumenina, Lubka T. Roumenina, Lubka T. Roumenina   +47 more
doaj   +1 more source

Low Cerebrospinal Fluid Levels of Hemopexin Are Associated With Increased Alzheimer's Pathology, Hippocampal Hypometabolism, and Cognitive Decline

Frontiers in Molecular Biosciences, 2020
Brain iron dyshomeostasis is a feature of Alzheimer's disease. Conventionally, research has focused on non-heme iron although degradation of heme from hemoglobin subunits can generate iron to augment the redox-active iron pool.
Azhaar A. Ashraf, Melanie Dani, Po-Wah So   +2 more
doaj   +1 more source

Use of hemopexin domains and monoclonal antibodies to hemopexin to probe the molecular determinants of hemopexin-mediated heme transport.

Journal of Biological Chemistry, 1988
Plasmin cleaves rabbit serum apohemopexin (Mr = 60,000) at a single site producing a heme-binding domain (I, Mr = 35,000) and a second domain (II, Mr = 25,000) (W. T. Morgan and A. Smith (1984) J. Biol. Chem. 259, 12001-12005). The absorbance spectra of heme-domain I are indicative of a bis-histidyl coordination complex with the central heme iron atom.
W T, Morgan, P, Muster, F M, Tatum, J, McConnell, T P, Conway, P, Hensley, A, Smith   +6 more
openaire   +2 more sources

Serum proteins as mediators of hemin efflux from red cell membranes: specificity of hemopexin [PDF]

, 1989
The involvement of the serum heme-binding proteins hemopexin and albumin in the clearance of erythrocyte membranes from toxic hemin was compared. In the presence of hemopexin initial rates of hemin efflux from resealed ghosts were faster and the amount ...
Shaklai, N., I. Solar, U. Muller-Eberhard, Muller-Eberhard, U., N. Shaklai, Solar, I.   +5 more
core   +1 more source