Results 11 to 20 of about 6,390 (173)

Hemopexin and Cancer [PDF]

International Journal of Molecular Sciences, 2022
Hemopexin is the plasma protein with the highest affinity for heme. Seminal studies have highlighted its role in different kinds of heme-associated disorders, but its implication in cancer has been neglected for a long time. Considering the emerging importance of heme in tumors, the present review proposes an update of the works investigating hemopexin
Veronica Fiorito, Emanuela Tolosano
openaire   +2 more sources

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction. [PDF]

PLoS ONE, 2018
During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states ...
John D Belcher, Chunsheng Chen, Julia Nguyen, Fuad Abdulla, Ping Zhang, Hao Nguyen, Phong Nguyen, Trevor Killeen, Sylvia M Miescher, Nathan Brinkman, Karl A Nath, Clifford J Steer, Gregory M Vercellotti   +12 more
doaj   +1 more source

Lack of Plasma Protein Hemopexin Results in Increased Duodenal Iron Uptake. [PDF]

PLoS ONE, 2013
PURPOSE:The body concentration of iron is regulated by a fine equilibrium between absorption and losses of iron. Iron can be absorbed from diet as inorganic iron or as heme.
Veronica Fiorito, Simonetta Geninatti Crich, Lorenzo Silengo, Silvio Aime, Fiorella Altruda, Emanuela Tolosano   +5 more
doaj   +1 more source

Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation

Frontiers in Immunology, 2022
Hemolysis, as a result of disease or exposure to biomaterials, is characterized by excess amounts of cell-free heme intravascularly and consumption of the protective heme-scavenger proteins in plasma.
Alexandra Gerogianni, Alexandra Gerogianni, Jordan D. Dimitrov, Alessandra Zarantonello, Victoria Poillerat, Satheesh Chonat, Satheesh Chonat, Kerstin Sandholm, Karin E. McAdam, Kristina N. Ekdahl, Kristina N. Ekdahl, Kristina N. Ekdahl, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Camilla Mohlin, Camilla Mohlin, Lubka T. Roumenina, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson   +20 more
doaj   +1 more source

Hemopexin: anti-inflammatory, pro-inflammatory, or both? [PDF]

Journal of Leukocyte Biology, 2010
Abstract Comment on Fink Editorial: premature to label Hx as an anti-inflammatory molecule? Are we ignoring its potential pleiotropic nature?
Bakker, W. W., Melgert, B. N., Faas, M. M.   +2 more
openaire   +1 more source

Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity

Cell Reports, 2021
Summary: Physical exercise has profound effects on quality of life and susceptibility to chronic disease; however, the regulation of skeletal muscle function at the molecular level after exercise remains unclear.
Rodrigo W. Alves de Souza, David Gallo, Ghee Rye Lee, Eri Katsuyama, Alexa Schaufler, Janick Weber, Eva Csizmadia, George C. Tsokos, Lauren G. Koch, Steven L. Britton, Ulrik Wisløff, Patricia C. Brum, Leo E. Otterbein   +12 more
doaj   +1 more source

Quality Assessment of Selected Protein Structures Derived from Homology Modeling and AlphaFold

Pharmaceuticals, 2023
With technology advancing, many prediction algorithms have been developed to facilitate the modeling of inherently dynamic and flexible macromolecules such as proteins.
Furkan Ayberk Binbay, Dhruv Chetanbhai Rathod, Ajay Abisheck Paul George, Diana Imhof   +3 more
doaj   +1 more source

Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis

Molecular Medicine, 2016
Infusion of the heme-binding protein hemopexin has been proposed as a novel approach to decrease heme-induced inflammation in settings of red blood cell breakdown, but questions have been raised as to possible side effects related to protease activity ...
Tian Lin, Jialin Liu, Feng Huang, Tjitske S R van Engelen, Sujatha R Thundivalappil, Frank E Riley, Michael Super, Alexander L Watters, Ann Smith, Nathan Brinkman, Donald E Ingber, H Shaw Warren   +11 more
doaj   +1 more source

Double-edged functions of hemopexin in hematological related diseases: from basic mechanisms to clinical application

Frontiers in Immunology, 2023
It is now understood that hemolysis and the subsequent release of heme into circulation play a critical role in driving the progression of various diseases.
Yijin Li, Renyu Chen, Chaofan Wang, Jun Deng, Shanshan Luo   +4 more
doaj   +1 more source