Results 11 to 20 of about 7,937 (161)
Lack of Plasma Protein Hemopexin Results in Increased Duodenal Iron Uptake. [PDF]
PLoS ONE, 2013 PURPOSE:The body concentration of iron is regulated by a fine equilibrium between absorption and losses of iron. Iron can be absorbed from diet as inorganic iron or as heme.
Veronica Fiorito +5 more
doaj +3 more sources
Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis
Molecular Medicine, 2016 Infusion of the heme-binding protein hemopexin has been proposed as a novel approach to decrease heme-induced inflammation in settings of red blood cell breakdown, but questions have been raised as to possible side effects related to protease activity ...
Tian Lin +11 more
doaj +2 more sources
Hemopexin as an Inhibitor of Hemolysis-Induced Complement Activation
Frontiers in Immunology, 2020 Hemopexin is the main plasmatic scavenger of cell-free heme, released in the context of intravascular hemolysis or major cell injury. Heme is indispensable for the oxygen transport by hemoglobin but when released outside of the erythrocytes it becomes a ...
Victoria Poillerat +8 more
doaj +2 more sources
Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction. [PDF]
PLoS ONE, 2018 During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states ...
John D Belcher +12 more
doaj +2 more sources
Biochemistry and Biophysics Reports, 2017 Proinflammatory cytokines, including TNF-α and IL-6, can contribute to insulin resistance. Conversely, insulin has some actions that can be considered anti-inflammatory.
J. Lee Franklin +2 more
doaj +2 more sources
Spatial transcriptome data from coronal mouse brain sections after striatal injection of heme and heme-hemopexin [PDF]
Data in Brief, 2022 Hemorrhagic stroke is a major cause of morbidity and mortality worldwide. Secondary mechanisms of brain injury adversely affect functional outcome in patients after intracranial hemorrhage.
Kevin Akeret +3 more
doaj +2 more sources
Hemopexin Purification From Human Cohn Fraction IV Paste and Its Biophysical Characterization and Functional Evaluation in Sickle Cell Disease Mice. [PDF]
Biotechnol BioengABSTRACT Hemopexin (Hpx) is an acute phase plasma protein that is responsible for sequestration and removal of cell‐free heme with very high affinity (Kd < 1 pM). Hpx expression in liver cells is induced following an inflammatory event such as severe hemolysis. Therefore, plasma Hpx has potential clinical relevance due to its' ability to bind free heme,
Lu S +8 more
europepmc +2 more sources
, 2022 Hemopexin is the plasma protein with the highest affinity for heme. Seminal studies have highlighted its role in different kinds of heme-associated disorders, but its implication in cancer has been neglected for a long time.
Fiorito, V. +3 more
core +1 more source
Hepatology, EarlyView., 2022 Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode +16 more
wiley +1 more source
A Model Peptide Reveals Insights into the Interaction of Human Hemopexin with Heme [PDF]
, 2022 Under hemolytic conditions, toxic heme is scavenged by hemopexin. Recently, the heme-binding properties of hemopexin have been reassessed, which revealed a K D of ~ 0.32 nM as well as a stoichiometry of one to two heme molecules binding to hemopexin.
Hopp, Marie-T. +13 more
core +1 more source