Results 11 to 20 of about 7,813 (203)

Hemopexin and Cancer [PDF]

International Journal of Molecular Sciences, 2022
Hemopexin is the plasma protein with the highest affinity for heme. Seminal studies have highlighted its role in different kinds of heme-associated disorders, but its implication in cancer has been neglected for a long time. Considering the emerging importance of heme in tumors, the present review proposes an update of the works investigating hemopexin
Veronica Fiorito, Emanuela Tolosano
core   +5 more sources

Hemopexin as an Inhibitor of Hemolysis-Induced Complement Activation

Frontiers in Immunology, 2020
Hemopexin is the main plasmatic scavenger of cell-free heme, released in the context of intravascular hemolysis or major cell injury. Heme is indispensable for the oxygen transport by hemoglobin but when released outside of the erythrocytes it becomes a ...
Victoria Poillerat, Thomas Gentinetta, Juliette Leon, Andreas Wassmer, Monika Edler, Carine Torset, Dandan Luo, Gerald Tuffin, Lubka T. Roumenina   +8 more
doaj   +2 more sources

Lack of Plasma Protein Hemopexin Results in Increased Duodenal Iron Uptake. [PDF]

PLoS ONE, 2013
PURPOSE:The body concentration of iron is regulated by a fine equilibrium between absorption and losses of iron. Iron can be absorbed from diet as inorganic iron or as heme.
Veronica Fiorito, Simonetta Geninatti Crich, Lorenzo Silengo, Silvio Aime, Fiorella Altruda, Emanuela Tolosano   +5 more
doaj   +3 more sources

Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis

Molecular Medicine, 2016
Infusion of the heme-binding protein hemopexin has been proposed as a novel approach to decrease heme-induced inflammation in settings of red blood cell breakdown, but questions have been raised as to possible side effects related to protease activity ...
Tian Lin, Jialin Liu, Feng Huang, Tjitske S R van Engelen, Sujatha R Thundivalappil, Frank E Riley, Michael Super, Alexander L Watters, Ann Smith, Nathan Brinkman, Donald E Ingber, H Shaw Warren   +11 more
doaj   +2 more sources

Plasma Hemopexin Activity in Pregnancy and Preeclampsia

Hypertension in Pregnancy, 2007
Plasma hemopexin activity, associated with increased vascular permeability, was evaluated in healthy pregnant and non-pregnant women and in pre-eclamptic women.Hemopexin activity and the hemopexin inhibitor, extracellular ATP, were assayed in plasma from pregnant (n = 10), preeclamptic (n = 9), and non-pregnant women (n = 10) using standard methods ...
Bakker, Winston W., Donker, Rogier B., Timmer, Albertus, van Pampus, Marielle G., van Son, Willem J., Aarnoudse, Jan G., van Goor, Harry, Niezen-Koning, Klary E., Navis, Gerjan, Borghuis, Theo, Jongman, Rianne M., Faas, Marijke M.   +11 more
openaire   +3 more sources

Insulin attenuates TNFα-induced hemopexin mRNA: An anti-inflammatory action of insulin in rat H4IIE hepatoma cells

Biochemistry and Biophysics Reports, 2017
Proinflammatory cytokines, including TNF-α and IL-6, can contribute to insulin resistance. Conversely, insulin has some actions that can be considered anti-inflammatory.
J. Lee Franklin, William L. Bennett, Joseph L. Messina   +2 more
doaj   +2 more sources

Hemopexin in newborn infants of diabetic mothers

Canadian Journal of Physiology and Pharmacology, 1968
Serum proteins from cord blood of 27 infants of diabetic and 16 infants of normal women of comparable gestational age (38–39 weeks) were studied by immunoelectrophoresis. In accord with our previous finding of elevated serum glycoprotein levels in newborn infants of diabetic mothers, a well-defined precipitation arc in the beta-one globulin region ...
O V, Sirek, A, Sirek, A, Bucalossi
openaire   +3 more sources

Hemopexin Purification From Human Cohn Fraction IV Paste and Its Biophysical Characterization and Functional Evaluation in Sickle Cell Disease Mice. [PDF]

Biotechnol Bioeng
ABSTRACT Hemopexin (Hpx) is an acute phase plasma protein that is responsible for sequestration and removal of cell‐free heme with very high affinity (Kd < 1 pM). Hpx expression in liver cells is induced following an inflammatory event such as severe hemolysis. Therefore, plasma Hpx has potential clinical relevance due to its' ability to bind free heme,
Lu S, Setua S, Khan MA, Bansal A, O'Boyle Q, Cabrales P, Irwin DC, Buehler PW, Palmer AF.   +8 more
europepmc   +2 more sources

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation

Frontiers in Immunology, 2022
Hemolysis, as a result of disease or exposure to biomaterials, is characterized by excess amounts of cell-free heme intravascularly and consumption of the protective heme-scavenger proteins in plasma.
Alexandra Gerogianni, Alexandra Gerogianni, Jordan D. Dimitrov, Alessandra Zarantonello, Victoria Poillerat, Satheesh Chonat, Satheesh Chonat, Kerstin Sandholm, Karin E. McAdam, Kristina N. Ekdahl, Kristina N. Ekdahl, Kristina N. Ekdahl, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Camilla Mohlin, Camilla Mohlin, Lubka T. Roumenina, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson   +20 more
doaj   +1 more source