Results 41 to 50 of about 7,937 (161)

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies

Frontiers in Physiology, 2019
Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked ...
Grigorios Kalapotharakos, Grigorios Kalapotharakos, Katja Murtoniemi, Katja Murtoniemi, Bo Åkerström, Esa Hämäläinen, Esa Hämäläinen, Eero Kajantie, Eero Kajantie, Eero Kajantie, Katri Räikkönen, Pia Villa, Hannele Laivuori, Hannele Laivuori, Hannele Laivuori, Hannele Laivuori, Stefan R. Hansson, Stefan R. Hansson   +17 more
doaj   +1 more source

Unraveling the Plasma Extracellular Vesicles Proteome: Predictors of Resistance in Immunotherapy of Advanced Melanoma

International Journal of Cancer, Volume 159, Issue 11, Page 2824-2834, 1 December 2026.
ABSTRACT Despite substantial clinical benefit from immune checkpoint inhibitors (ICI), advanced melanoma remains challenging due to frequent treatment resistance. Resistance may be intrinsic (primary) or emerge over time (secondary). Biomarkers predicting distinct resistance phenotypes before therapy are lacking.
Julian Kött, Glenn Geidel, Carmen M. T. Roeper, Lucija Ačkar, Bente Siebels, Hannah Voß, Hartmut Schlüter, Michaela Schweizer, Kilian Müller, Alessandra Rünger, Tim Zell, Benjamin Deitert, Ali Zeinal‐Abedini, Isabel Heidrich, Stefan W. Schneider, Klaus Pantel, Daniel J. Smit, Christoffer Gebhardt   +17 more
wiley   +1 more source

Plasma-Derived Hemopexin as a Candidate Therapeutic Agent for Acute Vaso-Occlusion in Sickle Cell Disease: Preclinical Evidence

, 2022
People living with sickle cell disease (SCD) face intermittent acute pain episodes due to vaso-occlusion primarily treated palliatively with opioids. Hemolysis of sickle erythrocytes promotes release of heme, which activates inflammatory cell adhesion ...
Kirstee Martin, Gregory M. Vercellotti, Andreas Wassmer, Roslyn Davis, Kalpeshkumar Patel, Monika Edler, Jacqueline Adam, Joseph Bain, Alexander Schaub, Chunsheng Chen, Svetlana Didichenko, Ping Zhang, Adrian Zürcher, John D. Belcher, Tanja Ruthsatz, Daniel Schu, Hadi Lioe, Gregory J. Kato, Nathan Brinkman, Marcel Mischnik, Matthias Pelzing, Gerald Höbarth, Lisa Ventrici, Julia Nguyen, Fuad Abdulla, Thomas Gentinetta, Meena Jain, Eva Herzog, Valérie Brügger-Verdon   +28 more
core   +1 more source

Hemopexin regulates acute-phase inflammatory response against pathogenetic infections in black rockfish (Sebastes schlegelii)

Comparative Immunology Reports
Hemopexin as an acute-phase protein binds heme with a high affinity and participates in a variety of processes of physiology and pathology. Hemopexin plays an important role in regulating inflammatory response by regulating pro-/anti-inflammatory ...
Chengbin Gao, Peng Sun, Xin Cai, Mengyu Tian, Chao Li   +4 more
doaj   +1 more source

Host Iron Nutritional Immunity Induced by a Live Yersinia pestis Vaccine Strain Is Associated with Immediate Protection against Plague

Frontiers in Cellular and Infection Microbiology, 2017
Prompt and effective elicitation of protective immunity is highly relevant for cases of rapidly deteriorating fatal diseases, such as plague, which is caused by Yersinia pestis. Here, we assessed the potential of a live vaccine to induce rapid protection
Ayelet Zauberman, Yaron Vagima, Avital Tidhar, Moshe Aftalion, David Gur, Shahar Rotem, Theodor Chitlaru, Yinon Levy, Emanuelle Mamroud   +8 more
doaj   +1 more source

Lost and Found: Western Honey Bee (Apis mellifera) Matrix Metalloproteinase 1

Ecology and Evolution, Volume 16, Issue 11, November 2026.
Despite considerable overall improvements in the Western honey bee (Apis mellifera) reference genome over the past two decades, some genes are missing in the current reference assembly (Amel_HAv3.1), potentially interfering with the meaningfulness of downstream analyses.
Jessica Braunisch, Ken Werner, Ulrich R. Ernst, Christian W. W. Pirk, Anja Buttstedt   +4 more
wiley   +1 more source

H3K9me3 inhibition reverses Alzheimer's progression by restoring synaptic and immune proteostasis across the brain–retina axis

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Epigenetic dysregulation is increasingly linked to aging and neurodegeneration, yet its contribution to retinal and brain pathology in Alzheimer's disease (AD) remains unclear. METHODS We quantified the repressive epigenetic mark histone H3 lysine 9 trimethylation (H3K9me3) in post mortem retinas and brains from donors spanning ...
Dieu‐Trang Fuchs, Jean‐Philippe Vit, Altan Rentsendorj, Yosef Koronyo, Julia Sheyn, Bhakta Prasad Gaire, Saba Shahin, Haoshen Shi, Oksana Chepurna, Miyah R. Davis, Jered W. Wilson, Stuart L. Graham, Vivek K. Gupta, Lon S. Schneider, Michael T. Kleinman, Tao Sun, Margaret Fahnestock, David A. Horne, Mehdi Mirzaei, Keith L. Black, Maya Koronyo‐Hamaoui   +20 more
wiley   +1 more source

Low Cerebrospinal Fluid Levels of Hemopexin Are Associated With Increased Alzheimer's Pathology, Hippocampal Hypometabolism, and Cognitive Decline

Frontiers in Molecular Biosciences, 2020
Brain iron dyshomeostasis is a feature of Alzheimer's disease. Conventionally, research has focused on non-heme iron although degradation of heme from hemoglobin subunits can generate iron to augment the redox-active iron pool.
Azhaar A. Ashraf, Melanie Dani, Po-Wah So   +2 more
doaj   +1 more source

Molecular and Proteomic Profiling of Human Cerebral Organoid‑Derived Small Extracellular Vesicles

Developmental Neurobiology, Volume 86, Issue 4, October 2026.
ABSTRACT Organoids are self‐organized, in vitro 3D structures derived from progenitor or pluripotent stem cells. During culture, these tissues secrete small extracellular vesicles (sEVs)—functional bioactive molecules—into their microenvironment. Here, we differentiated iPSC‐derived cerebral organoids (COs) under three culture conditions (static ...
Elifsu Polatlı, Burak Kahveci, Çağla Kiser, Nurhan Özlü, Gökhan Karakülah, Şermin Genç, Sinan Güven   +6 more
wiley   +1 more source