A Model Peptide Reveals Insights into the Interaction of Human Hemopexin with Heme [PDF]
, 2022 Under hemolytic conditions, toxic heme is scavenged by hemopexin. Recently, the heme-binding properties of hemopexin have been reassessed, which revealed a K D of ~ 0.32 nM as well as a stoichiometry of one to two heme molecules binding to hemopexin.
Hopp, Marie-T. +6 more
core +1 more source
Hemopexin: anti-inflammatory, pro-inflammatory, or both? [PDF]
Journal of Leukocyte Biology, 2010 Abstract Comment on Fink Editorial: premature to label Hx as an anti-inflammatory molecule? Are we ignoring its potential pleiotropic nature?
Bakker, W. W. +2 more
openaire +1 more source
Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity
Cell Reports, 2021 Summary: Physical exercise has profound effects on quality of life and susceptibility to chronic disease; however, the regulation of skeletal muscle function at the molecular level after exercise remains unclear.
Rodrigo W. Alves de Souza +12 more
doaj +1 more source
Quality Assessment of Selected Protein Structures Derived from Homology Modeling and AlphaFold
Pharmaceuticals, 2023 With technology advancing, many prediction algorithms have been developed to facilitate the modeling of inherently dynamic and flexible macromolecules such as proteins.
Furkan Ayberk Binbay +3 more
doaj +1 more source
Frontiers in Immunology, 2023 It is now understood that hemolysis and the subsequent release of heme into circulation play a critical role in driving the progression of various diseases.
Yijin Li +4 more
doaj +1 more source
Significance of Serum Hemopexin as A Prognostic Marker in Children with Idiopathic Nephrotic Syndrome [PDF]
Zagazig University Medical JournalBackground: Idiopathic nephrotic syndrome (INS) is the most common form of podocytopathy in children. Although the dramatic response to steroid therapy, steroid resistance occurs in 10% to 30% of cases.
Dalia Gameil +4 more
doaj +1 more source
Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli
Current Issues in Molecular Biology, 2021 In systemic hemolysis and in hematuric forms of kidney injury, the major heme scavenging protein, hemopexin (HPX), becomes depleted, and the glomerular microvasculature (glomeruli) is exposed to high concentrations of unbound heme, which, in addition to ...
Maria G. Detsika, Elias A. Lianos
doaj +1 more source
Systematic Analysis of Plasma-Derived Extracellular Vesicle-Enriched Samples in Age-Related Macular Degeneration Reveals Oxidative Stress Linked to Altered Lipid and Protein Profiles. [PDF]
J Extracell BiolABSTRACT Vision impairment caused by age‐related macular degeneration (AMD) is a global health priority. Retinal pathology is driven by ageing and exacerbated by genetic and environmental risk factors. Peripheral blood circulation is increasingly recognised as a contributor to disease initiation and progression, and a source of biomarkers to support ...
Kurzawa-Akanbi M +17 more
europepmc +2 more sources
Frontiers in Immunology, 2020 Shiga-toxin (Stx)-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS) is one of the most common causes of acute kidney injury in children.
Kioa L. Wijnsma +10 more
doaj +1 more source
Overexpression of Hemopexin in the Diabetic Eye [PDF]
, 2013 Hemopexin is a well-recognized permeability factor in the kidney, but its potential role in blood-retinal barrier (BRB) breakdown has not been explored.
Hernández, Cristina +3 more
core +1 more source