Results 21 to 30 of about 7,937 (161)

Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation

Frontiers in Immunology, 2022
Hemolysis, as a result of disease or exposure to biomaterials, is characterized by excess amounts of cell-free heme intravascularly and consumption of the protective heme-scavenger proteins in plasma.
Alexandra Gerogianni, Alexandra Gerogianni, Jordan D. Dimitrov, Alessandra Zarantonello, Victoria Poillerat, Satheesh Chonat, Satheesh Chonat, Kerstin Sandholm, Karin E. McAdam, Kristina N. Ekdahl, Kristina N. Ekdahl, Kristina N. Ekdahl, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Camilla Mohlin, Camilla Mohlin, Lubka T. Roumenina, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson   +20 more
doaj   +1 more source

Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity

Cell Reports, 2021
Summary: Physical exercise has profound effects on quality of life and susceptibility to chronic disease; however, the regulation of skeletal muscle function at the molecular level after exercise remains unclear.
Rodrigo W. Alves de Souza, David Gallo, Ghee Rye Lee, Eri Katsuyama, Alexa Schaufler, Janick Weber, Eva Csizmadia, George C. Tsokos, Lauren G. Koch, Steven L. Britton, Ulrik Wisløff, Patricia C. Brum, Leo E. Otterbein   +12 more
doaj   +1 more source

Quality Assessment of Selected Protein Structures Derived from Homology Modeling and AlphaFold

Pharmaceuticals, 2023
With technology advancing, many prediction algorithms have been developed to facilitate the modeling of inherently dynamic and flexible macromolecules such as proteins.
Furkan Ayberk Binbay, Dhruv Chetanbhai Rathod, Ajay Abisheck Paul George, Diana Imhof   +3 more
doaj   +1 more source

Double-edged functions of hemopexin in hematological related diseases: from basic mechanisms to clinical application

Frontiers in Immunology, 2023
It is now understood that hemolysis and the subsequent release of heme into circulation play a critical role in driving the progression of various diseases.
Yijin Li, Renyu Chen, Chaofan Wang, Jun Deng, Shanshan Luo   +4 more
doaj   +1 more source

Significance of Serum Hemopexin as A Prognostic Marker in Children with Idiopathic Nephrotic Syndrome [PDF]

Zagazig University Medical Journal
Background: Idiopathic nephrotic syndrome (INS) is the most common form of podocytopathy in children. Although the dramatic response to steroid therapy, steroid resistance occurs in 10% to 30% of cases.
Dalia Gameil, Ahmed Mustafa, Mohamed Gomaa, Naglaa Khalifa, Mona Elsharkawy   +4 more
doaj   +1 more source

Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli

Current Issues in Molecular Biology, 2021
In systemic hemolysis and in hematuric forms of kidney injury, the major heme scavenging protein, hemopexin (HPX), becomes depleted, and the glomerular microvasculature (glomeruli) is exposed to high concentrations of unbound heme, which, in addition to ...
Maria G. Detsika, Elias A. Lianos
doaj   +1 more source

Overexpression of Hemopexin in the Diabetic Eye [PDF]

, 2013
Hemopexin is a well-recognized permeability factor in the kidney, but its potential role in blood-retinal barrier (BRB) breakdown has not been explored.
Hernández, Cristina, Simó Canonge, Rafael, Garcia-Ramírez, Marta, Universitat Autònoma de Barcelona   +3 more
core   +1 more source

Heme as Possible Contributing Factor in the Evolvement of Shiga-Toxin Escherichia coli Induced Hemolytic-Uremic Syndrome

Frontiers in Immunology, 2020
Shiga-toxin (Stx)-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS) is one of the most common causes of acute kidney injury in children.
Kioa L. Wijnsma, Susan T. Veissi, Sem de Wijs, Thea van der Velden, Elena B. Volokhina, Elena B. Volokhina, Frank A. D. T. G. Wagener, Nicole. C. A. J. van de Kar, L. P. van den Heuvel, L. P. van den Heuvel, L. P. van den Heuvel   +10 more
doaj   +1 more source

Stromal expression of hemopexin is associated with lymph-node metastasis in pancreatic ductal adenocarcinoma.

PLoS ONE, 2020
Pancreatic ductal adenocarcinoma is one of the most aggressive types of cancer. Certain proteins in the tumor microenvironment have attracted considerable attention owing to their association with tumor invasion and metastasis.
Yukie Suzuki, Tatsuyuki Takadate, Masamichi Mizuma, Hiroki Shima, Takashi Suzuki, Tomoyoshi Tachibana, Mitsuhiro Shimura, Tatsuo Hata, Masahiro Iseki, Kei Kawaguchi, Takeshi Aoki, Hiroki Hayashi, Takanori Morikawa, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Kazuhiko Igarashi, Michiaki Unno   +17 more
doaj   +1 more source

TLR4 Signaling by Heme and the Role of Heme-Binding Blood Proteins

Frontiers in Immunology, 2020
Toll-like receptors (TLRs), also known as pattern recognition receptors, respond to exogenous pathogens and to intrinsic danger signals released from damaged cells and tissues.
Sabina Janciauskiene, Vijith Vijayan, Stephan Immenschuh   +2 more
doaj   +1 more source