Results 51 to 60 of about 7,937 (161)

Identification of the receptor scavenging hemopexin-heme complexes

, 2005
Heme released from heme-binding proteins on internal hemorrhage, hemolysis, myolysis, or other cell damage is highly toxic due to oxidative and proinflammatory effects.
Jacobsen, Christian, Møller, Holger J, Moestrup, Søren K, Højrup, Peter; id_orcid, Maniecki, Maciej B, Hvidberg, Vibeke   +5 more
core   +1 more source

Production of hemopexin by TNF-alpha stimulated human mesangial cells.

, 2003
BACKGROUND: Plasma hemopexin has been shown to induce proteinuria after intrarenal infusion in rats, as well as glomerular alterations identical to those seen in corticosteroid-responsive nephrotic syndrome (CRNS). The question emerged whether also renal
Goor, H. van, Borghuis, T., Kapojos, J.J., Bakker, W., Poelstra, K., Berg, A.P. van den, Loo, D.M.W.M. te   +6 more
core   +2 more sources

An All-Recombinant Protein-Based Culture System Specifically Identifies Hematopoietic Stem Cell Maintenance Factors

Stem Cell Reports, 2017
Hematopoietic stem cells (HSCs) are considered one of the most promising therapeutic targets for the treatment of various blood disorders. However, due to difficulties in establishing stable maintenance and expansion of HSCs in vitro, their insufficient ...
Aki Ieyasu, Reiko Ishida, Takaharu Kimura, Maiko Morita, Adam C. Wilkinson, Kazuhiro Sudo, Toshinobu Nishimura, Jun Ohehara, Yoko Tajima, Chen-Yi Lai, Makoto Otsu, Yukio Nakamura, Hideo Ema, Hiromitsu Nakauchi, Satoshi Yamazaki   +14 more
doaj   +1 more source

Chlorine inhalation induces acute chest syndrome in humanized sickle cell mouse model and ameliorated by postexposure hemopexin

Redox Biology, 2021
Triggering factors of Acute Chest Syndrome (ACS) is a leading cause of death in patients with Sickle Cell Disease (SCD) and targeted therapies are limited.
Ammar Saadoon Alishlash, Muna Sapkota, Israr Ahmad, Kelsey Maclin, Noor A. Ahmed, Adam Molyvdas, Stephen Doran, Carolyn J. Albert, Saurabh Aggarwal, David A. Ford, Namasivayam Ambalavanan, Tamas Jilling, Sadis Matalon   +12 more
doaj   +1 more source

Evaluation of Hemolysis Risk, Renal Function, and Safety Among Two Pulsed Field Ablation Systems: A Systematic Review and Meta‐Analysis

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
Pentaspline systems were associated with more pronounced laboratory markers of hemolysis, although clinically significant renal dysfunction remained uncommon and evidence regarding clinical consequences remains limited. ABSTRACT This study investigated the hemolysis risk, renal, and safety outcomes between two pulsed field ablation (PFA) systems.
Abdalrahman Al‐Slaimieh, Ibrahim Ghayada, Rand Al‐Huneidy, Mohammad Shahin, Khaled Abukhalaf, Waleed Alomari, Khaled Marwa, Saeed Abdel Kamel, Yahya Almazaraa, Mohammad Hajjiri, Abdallah Al‐Ani   +10 more
wiley   +1 more source

Multiple correlation analyses of [EPO] with [hemopexin + total heme].

, 2016
Multiple correlation analyses of [EPO] with [hemopexin + total heme].
Pierre-André Cazenave (69432), Shobhona Sharma (144486), Bidyut Das (3148752), Serge Nataf (270268), Laurent Pays (3148749), Fabien Herbert (255962), Nicolas Tchitchek (242337), Esther Dalko (276837), Sylviane Pied (69433), Balachandran Ravindran (120474)   +9 more
core   +1 more source

Microarray and large-scale in silico-based identification of genes functionally related to Haptoglobin and/or Hemopexin

, 2006
Haptoglobin and Hemopexin are plasma acute phase proteins that bind with high-affinity hemoglobin and heme, respectively. They play a key role in the protection against oxidative stress and inflammation.
Fagoonee S, Di Cunto F, Altruda F, Vozzi D, Silengo L, Pellegrino M, Tolosano E, Volinia S, Gasparini P   +8 more
core   +2 more sources

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, Volume 13, Issue 10, Page 2405-2418, October 2026.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source

Skeletal muscle atrophy‐induced hemopexin accelerates onset of cognitive impairment in Alzheimer's disease

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Alzheimer's disease (AD) is an unmet medical need worldwide, and physical inactivity is a risk factor for AD. Performing physical exercise is difficult at old age, and thus, decline in physical movement may be a cause of age‐associated ...
Tsukasa Nagase, Chihiro Tohda
doaj   +1 more source

Iron Homeostasis and Liver Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 20, October 2026.
ABSTRACT Iron is an essential micronutrient whose ability to cycle between ferric (Fe3+) and ferrous (Fe2+) states makes it crucial for physiological processes, including oxygen transport, DNA synthesis, and oxidative phosphorylation. However, because both deficiency and excess can cause severe pathology, precise regulation is critical. The liver plays
Peng Yang, Zhitian Shi, Qin Huang, Zhihong Tu, Yue Sun, Lin Wang, Yonglong Wei   +6 more
wiley   +1 more source