Results 71 to 80 of about 7,813 (203)

Testican‐1‐MMP axis in tumour extracellular matrix (ECM) remodelling: interaction dynamics analysis and an in silico perspective

The Journal of Pathology, Volume 269, Issue 4-5, Page 433-445, August 2026.
Abstract The extracellular matrix (ECM) plays a pivotal role in facilitating tumour development, invasiveness, metastasis, and immunoevasive processes through dynamic ECM remodelling processes. Testican‐1 (SPOCK1), an excretory matricellular proteoglycan, is suggested to exert a role in the facilitation of ECM remodelling processes through interacting ...
Sepideh Youssefi, Kiarash Saleki, Prerna Kadam, Amirreza Mazloomi, Abhik Mukherjee, Lodewijk V Dekker, Abdolrahman S Nateri   +6 more
wiley   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, Volume 81, Issue 8, Page 2675-2712, August 2026.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

Type I collagen abrogates the clathrin-mediated internalization of membrane type 1 matrix metalloproteinase (MT1-MMP) via the MT1-MMP hemopexin domain [PDF]

, 2006
Type I collagen (Col I)-stimulated matrix metalloproteinase-2 (MMP-2) activation via membrane type 1 MMP (MT1-MMP) involves both a transcriptional increase in MT1-MMP expression and a nontranscriptional response mediated by preexisting MT1-MMP.
Thompson, Erik W., Sato, H., Ruangpanit, N., Lafleur, M. A., Mercuri, F. A., Seiki, M.   +5 more
core   +1 more source

Extracellular vesicles derived from immobilization‐induced atrophic muscle of male mice contain distinct microRNA profiles and impact mRNA profiles in brain neurons

Physiological Reports, Volume 14, Issue 16, August 2026.
Abstract Muscle atrophy caused by inactivity leads to declines in multiple physiological functions, including brain function. Although skeletal muscle is known to secrete extracellular vesicles (EVs) such as exosomes, how inactivity‐induced muscle atrophy alters the properties and functions of these EVs remains unclear.
Noriaki Kawanishi, Shuichi Machida, Katsuhiko Suzuki   +2 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, Volume 16, Issue 7, Page 1414-1427, July 2026.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes

, 2008
Hemopexin is an abundant plasma protein that effectively scavenges heme. When infused into rats, hemopexin induces reversible proteinuria, and activated hemopexin is increased in children with minimal change nephrotic syndrome. These observations suggest
Ni, Lan, Ni, L, Satchell, Simon, Bakker, WW, Lennon, Rachel; id_orcid, Welsh, Gavin I., Welsh, GI, Welsh, Gavin I, Mathieson, Peter W, Coward, Richard J., Bakker, Winston W., Coward, Richard J, Saleem, Moin A, Satchell, S, Mathieson, Peter W., Bakker, Winston W, Singh, A, Saleem, Moin A., Lennon, Rachel, Saleem, MA, Mathieson, PW, Singh, Anurag, Lennon, R, Coward, RJ   +23 more
core   +1 more source

Plasma-Derived Hemopexin as a Candidate Therapeutic Agent for Acute Vaso-Occlusion in Sickle Cell Disease: Preclinical Evidence

, 2022
People living with sickle cell disease (SCD) face intermittent acute pain episodes due to vaso-occlusion primarily treated palliatively with opioids. Hemolysis of sickle erythrocytes promotes release of heme, which activates inflammatory cell adhesion ...
Kirstee Martin, Gregory M. Vercellotti, Andreas Wassmer, Roslyn Davis, Kalpeshkumar Patel, Monika Edler, Jacqueline Adam, Joseph Bain, Alexander Schaub, Chunsheng Chen, Svetlana Didichenko, Ping Zhang, Adrian Zürcher, John D. Belcher, Tanja Ruthsatz, Daniel Schu, Hadi Lioe, Gregory J. Kato, Nathan Brinkman, Marcel Mischnik, Matthias Pelzing, Gerald Höbarth, Lisa Ventrici, Julia Nguyen, Fuad Abdulla, Thomas Gentinetta, Meena Jain, Eva Herzog, Valérie Brügger-Verdon   +28 more
core   +1 more source

A Novel Plasma Heme Assay Reveals Disease Severity in Beta‐Thalassemia and Sickle Cell Anemia

American Journal of Hematology, Volume 101, Issue 7, Page 1706-1716, July 2026.
ABSTRACT Anemia results from imbalanced hemoglobin or red blood cell production and clearance. Hemolytic anemia, caused by premature red blood cell removal, can be intravascular (in blood) or extravascular (erythrophagocytosis). Hemolysis is common in Sickle Cell Disease (SCD) and Beta‐Thalassemia anemia (β‐thalassemia), the most prevalent inherited ...
Laurent Kiger, Nicolas Hebert, Laura Bencheikh, Vincent Malcor Deydier de Pierrefeu, Anne‐Laure Pham Hung d’Alexandry d’Orengiani, Sandia Adypagavane, Meghan Perkins, Laura Matabishi‐Bibi, France Pirenne, Claire Berquet, Stephane Moutereau, Serge Pissard, Frédéric Galactéros, Michael C. Marden, Pablo Bartolucci   +14 more
wiley   +1 more source

Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
wiley   +1 more source

Hemopexin in severe inflammation and infection: mouse models and human diseases

, 2015
Introduction: Cell-free plasma hemoglobin is associated with poor outcome in patients with sepsis. Extracellular hemoglobin and secondarily released heme amplify inflammation in the presence of microbial TLR ligands and/or endogenous mediators. Hemopexin,
Riley, Frank E, Fagan, Shawn, Maita, Dayana, Warren, H Shaw, Berra, Lorenzo, Christou, Helen, Van Marter, Linda, Thundivalappil, Sujatha R, Christiani, David, Hambsch, Jasmin, Lin, Tian   +10 more
core   +1 more source