Results 81 to 90 of about 7,937 (161)

Lack of plasma protein hemopexin dampens mercury-induced autoimmune response in mice

, 2008
Several factors affect the autoimmune response, including iron-dependent modulation of T cells. Hemopexin is the plasma protein with the highest binding affinity to heme.
Silengo Lorenzo, Altruda Fiorella, Stoltenberg Meredin, Caorsi Cristiana, Bussolati Benedetta, Giovarelli Mirella, Tolosano Emanuela, Camussi Giovanni, Fagoonee Sharmila   +8 more
core  

Hemopexin in severe inflammation and infection: mouse models and human diseases

, 2015
Introduction: Cell-free plasma hemoglobin is associated with poor outcome in patients with sepsis. Extracellular hemoglobin and secondarily released heme amplify inflammation in the presence of microbial TLR ligands and/or endogenous mediators. Hemopexin,
Riley, Frank E, Fagan, Shawn, Maita, Dayana, Warren, H Shaw, Berra, Lorenzo, Christou, Helen, Van Marter, Linda, Thundivalappil, Sujatha R, Christiani, David, Hambsch, Jasmin, Lin, Tian   +10 more
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Inhibition of Neutrophil Migration by Hemopexin Leads to Increased Mortality Due to Sepsis in Mice

, 2011
Rationale: The reduction of neutrophil migration to the bacterial focus is associated with poor outcome in sepsis. Objectives: The objective of this study was to identify soluble substances in the blood of septic mice that inhibit neutrophil migration ...
HIRSCH, Emilio, Fabrício O. Souto, Sérgio H. Ferreira, Fernando Q. Cunha, ROSA, Jose C., FREITAS, Andressa, MESTRINER, Fabiola L. A. C., GREENE, Lewis J., Lewis J. Greene, SOUTO, Fabricio O., FERREIRA, Sergio H., Fiorella Altruda, Francesca Vinchi, ALTRUDA, Fiorella, Carlotta Costa, José C. Rosa, Andressa Freitas, Emilio Hirsch, TOLOSANO, Emanuela, Fabíola L. A. C. Mestriner, VINCHI, Francesca, CUNHA, Fernando Q., COSTA, Carlotta, Emanuela Tolosano, José C. Alves-Filho, SPILLER, Fernando, Fernando Spiller, ALVES-FILHO, Jose C., LAURE, Helen J., Helen J. Laure   +29 more
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Targeting heme in sickle cell disease: new perspectives on priapism treatment

Frontiers in Physiology
Men with sickle cell disease (SCD) frequently experience priapism, defined as prolonged, painful erections occurring without sexual arousal or desire. This urological emergency can lead to penile fibrosis and permanent erectile dysfunction if not treated
Tammyris Helena Rebecchi Silveira, Fabiano Beraldi Calmasini, Mariana Gonçalves de Oliveira, Fernando Ferreira Costa, Fábio Henrique Silva   +4 more
doaj   +1 more source

Plasma hemopexin as a potential regulator of vascular responsiveness to angiotensin II

, 2013
This brief review focuses on the functional activities of plasma hemopexin recently recognized by several authors. In particular, the protease-like activity of hemopexin in vitro is linked with downregulation of the vascular angiotensin II receptor in ...
Bakker, W.W., Buijnink, J., Spaans, F., Borghuis, T., el Bakkali, L., van Dijk, E., Faas, M.M., van Goor, Harry; id_orcid   +7 more
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Interaction of heme and heme–hemopexin with an extracellular oxidant system used to measure cell growth-associated plasma membrane electron transport

, 2007
Since redox active metals are often transported across membranes into cells in the reduced state, we have investigated whether exogenous ferri-heme or heme bound to hemopexin (HPX), which delivers heme to cells via receptor-mediated endocytosis, interact
Rish, Kimberly R., Swartzlander, Ryan, Sadikot, Takrima N., Berridge, Michael V., Smith, Ann   +4 more
core   +1 more source

Hemopexin alleviates sterile inflammation in ischemia-reperfusion-induced lung injury

Frontiers in Immunology
IntroductionPulmonary ischemia-reperfusion (IR) injury (IRI) plays a significant role in various lung disorders and is a key factor in the development of primary graft dysfunction following lung transplantation.
Tomoyuki Nakagiri, Tomoyuki Nakagiri, Nadine R. Köhler, Sabina Janciauskiene, Sabina Janciauskiene, Sabina Janciauskiene, Lavinia Neubert, Lavinia Neubert, Ann-Kathrin Knöfel, Ann-Kathrin Knöfel, Pooja Pradhan, Arjang Ruhparwar, Fabio Ius, Fabio Ius, Stephan Immenschuh   +14 more
doaj   +1 more source

Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme

Cell Reports, 2018
Summary: The clostridium-like ecto-ADP-ribosyltransferase ARTC1 is expressed in a highly restricted manner in skeletal muscle and heart tissue. Although ARTC1 is well studied, the identification of ARTC1 targets in vivo and subsequent characterization of
Mario Leutert, Stephan Menzel, Rickmer Braren, Björn Rissiek, Ann-Katrin Hopp, Kathrin Nowak, Lavinia Bisceglie, Peter Gehrig, Hui Li, Anna Zolkiewska, Friedrich Koch-Nolte, Michael O. Hottiger   +11 more
doaj   +1 more source

MOESM1 of Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease

, 2018
Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell ...
Clifford Steer (4589965), Gregory Vercellotti (5816345), Phong Nguyen (694573), John Belcher (2378026), Ping Zhang (86495), Ann Smith (372228), Fuad Abdulla (694572), Chunsheng Chen (694570), Julia Nguyen (694571), Carlos Nowotny (5816348)   +9 more
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Multiple correlation analyses of [EPO + hemopexin + total heme] with [TNF-α + IL-10 + IP-10 + MCP-1] during NCM.

, 2016
Multiple correlation analyses of [EPO + hemopexin + total heme] with [TNF-α + IL-10 + IP-10 + MCP-1] during NCM.
Pierre-André Cazenave (69432), Shobhona Sharma (144486), Bidyut Das (3148752), Serge Nataf (270268), Laurent Pays (3148749), Fabien Herbert (255962), Nicolas Tchitchek (242337), Esther Dalko (276837), Sylviane Pied (69433), Balachandran Ravindran (120474)   +9 more
core   +1 more source