Results 81 to 90 of about 7,813 (203)

Interleukin-4, hemopexin, and lipoprotein-associated phospholipase A2 are significantly increased in patients with unstable carotid plaque

Open Chemistry, 2019
This study aimed to compare the plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2), hemopexin (Hpx), and interleukin-4 (IL-4) in patients with carotid artery atherosclerosis based on neurological symptoms and plaque histopathology and to ...
Stefanic Peter, Sihotsky Vladimir, Hertelyova Zdenka, Kopolovets Ivan, Mathews Abraham John, Toth Stefan, Kubikova Maria, Svajdler Peter, Mucha Rastislav, Vasko Lukas, Virag Michal, Pribula Vit, Pella Dominik, Frankovicova Maria   +13 more
doaj   +1 more source

Alliin Regulates Intracellular Cholesterol Metabolism Through the PCSK9/LDLR Axis in Ox‐LDL‐Induced HepG2 Cells: A Proteomics Study

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This study demonstrates that alliin reduces intracellular lipid accumulation and alters protein expression in ox‐LDL‐induced HepG2 cells. These effects are linked to cholesterol metabolism and the PPAR and PI3K/Akt signaling pathways. Mechanistically, alliin regulates the PCSK9/LDLR axis, indicating its role in maintaining intracellular cholesterol ...
Yuanyuan Tang, Xiaoshi Liu
wiley   +1 more source

Plasma Hemopexin as a Potential Regulator of Vascular Responsiveness to Angiotensin II

, 2013
This brief review focuses on the functional activities of plasma hemopexin recently recognized by several authors. In particular, the protease-like activity of hemopexin in vitro is linked with downregulation of the vascular angiotensin II receptor in ...
Bakker, W.W., van Goor, H., Buijnink, J., Spaans, F., van Goor, Harry, Borghuis, T., el Bakkali, L., van Dijk, E., Faas, M.M., van Goor, Harry; id_orcid   +9 more
core   +1 more source

Silencing the Signal: The Metastasis Suppressor NDRG1 Disrupts Small Extracellular Vesicle‐Mediated Crosstalk in Pancreatic Cancer

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
NDRG1 suppresses pancreatic cancer progression by disrupting small extracellular vesicle biogenesis, altering cargo composition, and inhibiting EV uptake by cancer cells—thereby impairing tumour–stroma communication and fibrotic activation. This study reveals NDRG1 as a novel regulator of extracellular vesicle dynamics and a promising therapeutic ...
Jiawei Chang, Shafi Alenizi, Heloisa Zaccaron Milioli, Winston Lay, Saranya Pounraj, Yujie Li, Mekonnen Sisay Shiferaw, Elham Hosseini‐Beheshti, Zaklina Kovacevic   +8 more
wiley   +1 more source

Multiple correlation analyses of [EPO] with [hemopexin + total heme].

, 2016
Multiple correlation analyses of [EPO] with [hemopexin + total heme].
Pierre-André Cazenave (69432), Shobhona Sharma (144486), Bidyut Das (3148752), Serge Nataf (270268), Laurent Pays (3148749), Fabien Herbert (255962), Nicolas Tchitchek (242337), Esther Dalko (276837), Sylviane Pied (69433), Balachandran Ravindran (120474)   +9 more
core   +1 more source

Identification of small molecules that bind to the hemopexin domain of matrix metalloproteinase-9 [PDF]

, 2012
Matrix metalloproteinases (MMPs) play an important role in cancer progression by degrading extracellular matrix components, promoting tumor cell migration, and thus enhancing tumor metastasis.
Li, Zhu
core   +1 more source

Data demonstrating the anti-oxidant role of hemopexin in the heart

Data in Brief, 2017
The data presented in this article are related to the research article entitled Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress (G. Ingoglia, C. M. Sag, N. Rex, L. De Franceschi, F. Vinchi, J. Cimino, S.
Giada Ingoglia, Can Martin Sag, Nikolai Rex, Lucia De Franceschi, Francesca Vinchi, James Cimino, Sara Petrillo, Stefan Wagner, Klaus Kreitmeier, Lorenzo Silengo, Fiorella Altruda, Lars S. Maier, Emilio Hirsch, Alessandra Ghigo, Emanuela Tolosano   +14 more
doaj   +1 more source

Hemopexin is required for adult neurogenesis in the subventricular zone/olfactory bulb pathway

, 2018
The neural stem cells (NSCs) of the subventricular zone (SVZ) reside within a specialized niche critical for neurogenesis. Hemopexin, a plasma glycoprotein, has been extensively studied as a heme scavenger at the systemic level.
Zhida Su, Yanling Zhu, Mengjia Chen, Li Cao, Cheng He, Yi Zhang, Yinyan Pu, Yang Qiu, Yimin Yuan, Aijun Huang   +9 more
core   +1 more source

Potential role of hemopexin in venous thromboembolism (VTE) mediated through effects on apoptosis-related proteins

Hematology
Objective: The limited understanding of venous thromboembolism (VTE) has hindered the development of novel treatment approaches. This study aimed to identify critical factors underlying VTE.Methods: The isobaric tags for relative and absolute ...
Jun-li Zhuang, Xiao-hui Yu, Hua-gang Liu, Peng Tang, Hong-ping Deng, Jie Li, Jiang-qiao Zhou, Zhong-jun Zhang   +7 more
doaj   +1 more source

Is Hemopexin a Nephrotoxin or a Marker of Kidney Injury in Renal Ischemia-Reperfusion?

Biomolecules
Destabilization of heme proteins is recognized to play a role in acute kidney injury (AKI). Hemopexin (Hpx), known for its role in binding heme, mitigates free heme toxicity. Despite this, the potential adverse effects of Hpx deposition in kidney tissues
You Hyun Jeon, Eun-Joo Oh, Se-Hyun Oh, Jeong-Hoon Lim, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Yong-Lim Kim, Chan-Duck Kim   +9 more
doaj   +1 more source