Results 11 to 20 of about 207,281 (307)
Protein interactions with heme are vital for pathogenic bacteria, particularly in the utilization of heme as an iron source [PDF]
, 2023 Iron is an essential nutrient for many pathogenic bacteria, and the most abundant source of the metal in the host is heme. Heme is often degraded by a heme oxygenase, and the first such enzyme (HO-1) was discovered in mammals.
Lyles, Kristin V
core +1 more source
Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc<sub>1</sub>. [PDF]
FEBS Open BioThe review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Wójcik-Augustyn A +2 more
europepmc +2 more sources
Biomolecules, 2022 In patients, endometrial hyperplasia (EH) is often accompanied by abnormal uterine bleeding (AUB), which is prone to release large amounts of heme. However, the role of excess heme in the migration and infiltration of immune cells in EH complicated by ...
Lu-Yu Ruan +8 more
doaj +1 more source
Hsp90 in Human Diseases: Molecular Mechanisms to Therapeutic Approaches
Cells, 2022 The maturation of hemeprotein dictates that they incorporate heme and become active, but knowledge of this essential cellular process remains incomplete. Studies on chaperon Hsp90 has revealed that it drives functional heme maturation of inducible nitric
Mamta P. Sumi, Arnab Ghosh
doaj +1 more source
Influence of Body Composition on Physical Fitness in Adolescents
Medicina, 2020 Background and objectives: Childhood obesity is one of the main public health issues facing advanced societies. The Spanish population presents 28.6% overweight or obese adolescents, and Extremadura, 22.3%.
María Mendoza-Muñoz +5 more
doaj +1 more source
Frontiers in Microbiology, 2021 Iron is an important micronutrient that is required by bacteria to proliferate and to cause disease. Many bacterial pathogens forage iron from human hemoglobin (Hb) during infections, which contains this metal within heme (iron–protoporphyrin IX ...
Ken Ellis-Guardiola +6 more
doaj +1 more source
Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora. [PDF]
FEBS Open BioThis study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Azizi J +6 more
europepmc +2 more sources
Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation
Frontiers in Cell and Developmental Biology, 2021 Augmenter of liver regeneration (ALR) is a critical multi-isoform protein with its longer isoform, located in the mitochondrial intermembrane space, being part of the mitochondrial disulfide relay system (DRS).
Yaschar Kabiri +12 more
doaj +1 more source
Characterizing the Heme Uptake Proteins HtaB and ChtB in Corynebacterium diphtheriae [PDF]
, 2020 Corynebacterium diphtheriae is a Gram-positive, pathogenic bacterium. Pathogenic bacteria require iron as a key nutrient for survival. C. diphtheriae utilizes a direct heme uptake system in which the heme binds to a receptor protein that transfers the ...
Ferrell, Brandon L
core +1 more source
Frontiers in Microbiology, 2021 Background: Persisters are important reasons for persistent infections, and they can lead to antibiotic treatment failure in patients and consequently chronic infection.
Xuyang Wang +8 more
doaj +1 more source