Results 41 to 50 of about 207,281 (307)

Heme oxygenation and the widening paradigm of heme degradation [PDF]

Archives of Biochemistry and Biophysics, 2014
Heme degradation through the action of heme oxygenase (HO) is unusual in that it utilizes heme as both a substrate and cofactor for its own degradation. HO catalyzes the oxygen-dependent degradation of heme to biliverdin with the release of CO and "free" iron.
Angela, Wilks, Geoffrey, Heinzl
openaire   +2 more sources

Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection [PDF]

, 2013
Heme oxygenases (HO) catalyze the rate-limiting step of heme degradation. The cytoprotective action of the inducible HO-1 isoform, encoded by the Hmox1 gene, is required for host protection against systemic infections. Here we report that upregulation of
Larsen, Rasmus, Appelberg, Rui, Sandro Silva Gomes, Rasmus Larsen, Miguel Parreira Soares, Soares, Miguel Parreira, Maria Salome Gomes, Silva-Gomes, Sandro, Gomes, Maria Salomé, Rui Appelberg, Sandro Silva-Gomes   +10 more
core   +1 more source

Could Heme Oxygenase-1 Be a New Target for Therapeutic Intervention in Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome?

Frontiers in Cellular and Infection Microbiology, 2018
Malaria is a serious disease and was responsible for 429,000 deaths in 2015. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the main clinical complications of severe malaria; it is characterized by a high mortality rate and ...
Marcelo L. M. Pereira, Claudio R. F. Marinho, Sabrina Epiphanio   +2 more
doaj   +1 more source

Heme-Derived Metabolic Signals Dictate Immune Responses

Frontiers in Immunology, 2020
Heme is one of the most abundant molecules in the body acting as the functional core of hemoglobin/myoglobin involved in the O2/CO2 carrying in the blood and tissues, redox enzymes and cytochromes in mitochondria.
Giacomo Canesin, Seyed M. Hejazi, Kenneth D. Swanson, Barbara Wegiel   +3 more
doaj   +1 more source

Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages

Frontiers in Immunology, 2017
Tumor-associated macrophages (TAMs) frequently help to sustain tumor growth and mediate immune suppression in the tumor microenvironment (TME). Here, we identified a subset of iron-loaded, pro-inflammatory TAMs localized in hemorrhagic areas of the TME ...
Milene Costa da Silva, Milene Costa da Silva, Milene Costa da Silva, Milene Costa da Silva, Milene Costa da Silva, Michael O. Breckwoldt, Michael O. Breckwoldt, Francesca Vinchi, Francesca Vinchi, Margareta P. Correia, Ana Stojanovic, Carl Maximilian Thielmann, Carl Maximilian Thielmann, Michael Meister, Michael Meister, Thomas Muley, Thomas Muley, Arne Warth, Arne Warth, Michael Platten, Michael Platten, Matthias W. Hentze, Adelheid Cerwenka, Adelheid Cerwenka, Martina U. Muckenthaler, Martina U. Muckenthaler, Martina U. Muckenthaler   +26 more
doaj   +1 more source

Convenient Heme Nanorod Modified Electrode for Quercetin Sensing by Two Common Electrochemical Methods

Micromachines, 2021
Quercetin (Qu) is one of the most abundant flavonoids in the human diet. High concentrations of Qu can easily cause adverse effects and induce inflammation, joint pain and stiffness.
Jin-Guang Liu, Jia-Zheng Wan, Qing-Min Lin, Guo-Cheng Han, Xiao-Zhen Feng, Zhencheng Chen   +5 more
doaj   +1 more source

Red meat and colon cancer : should we become vegetarians, or can we make meat safer ? [PDF]

, 2011
The effect of meat consumption on cancer risk is a controversial issue. However, recent meta-analyses show that high consumers of cured meats and red meat are at increased risk of colorectal cancer.
Denis E. Corpet, Corpet, Denis, Corpet, Denis E.   +2 more
core   +1 more source

Global Analysis of Heme Proteins Elucidates the Correlation between Heme Distortion and the Heme-Binding Pocket

, 2022
Heme proteins play diverse and important biological roles, from electron transfer and chemical catalysis to oxygen transport and/or storage. Although the distortion of heme porphyrin correlates with the physical properties of heme, such as the redox ...
Yusuke Kanematsu, Yu Takano (565805), Takashi Yoshida, Takuma Tanioka, Yu Takano, Takuma Tanioka (12085573), Hiroko X. Kondo, Hiroko X. Kondo (2191699), Masanori Fujii (5104106), Yusuke Kanematsu (1597102), Takashi Yoshida (47738), Masanori Fujii   +11 more
core   +2 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Effects of Bodypump Training on Blood Pressure and Physical Fitness in Sedentary Older Adults with Hypertension: A Randomized Trial

Physiologia
Background/Objectives: Hypertension is a leading cause of cardiovascular morbidity and mortality, particularly in older adults, pharmacological therapy is effective, but side effects and limited adherence highlight the need for non-pharmacological ...
Manuel Jesús Rodríguez Chavarría, Manuel Chavarrías-Olmedo, Jorge Pérez-Gómez   +2 more
doaj   +1 more source