Results 41 to 50 of about 187,269 (312)

Maturation of Plastid c-type Cytochromes

Frontiers in Plant Science, 2017
Cytochromes c are hemoproteins, with the prosthetic group covalently linked to the apoprotein, which function as electron carriers. A class of cytochromes c is defined by a CXXCH heme-binding motif where the cysteines form thioether bonds with the vinyl ...
Stéphane T. Gabilly, Stéphane T. Gabilly, Patrice P. Hamel, Patrice P. Hamel   +3 more
doaj   +1 more source

Endothelial TLR4 Expression Mediates Vaso-Occlusive Crisis in Sickle Cell Disease

Frontiers in Immunology, 2021
Heme, released from red blood cells in sickle cell disease (SCD), interacts with toll-like receptor 4 (TLR4) to activate NF-κB leading to the production of cytokines and adhesion molecules which promote inflammation, pain, and vaso-occlusion.
Joan D. Beckman, Fuad Abdullah, Chunsheng Chen, Rachel Kirchner, Dormarie Rivera-Rodriguez, Zachary M. Kiser, Aithanh Nguyen, Ping Zhang, Julia Nguyen, Robert P. Hebbel, John D. Belcher, Gregory M. Vercellotti   +11 more
doaj   +1 more source

Heme-Induced Biomarkers Associated with Red Meat Promotion of colon Cancer Are Not Modulated by the Intake of Nitrite [PDF]

, 2013
Red and processed meat consumption is associated with the risk of colorectal cancer. Three hypotheses are proposed to explain this association, via heme-induced oxidation of fat, heterocyclic amines, or N-nitroso compounds.
Tache, Sylvaine, Kunhle, Gunter G C, Taché, Sylviane, Pierre, Fabrice H., Kunhle, Gunter G.C., Corpet, Dennis E., Kunhle, Gunter G. C., Chenni, Fatima Z, Hobbs, Ditte A, Pierre, Fabrice, Kuhnle, Gunter G. C., Hobbs, Ditte A., Naud, Nathalie, Pierre, Fabrice H.F., Guéraud, Françoise, Chenni, Fatima Z., Corpet, Denis E.   +16 more
core   +1 more source

Could Heme Oxygenase-1 Be a New Target for Therapeutic Intervention in Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome?

Frontiers in Cellular and Infection Microbiology, 2018
Malaria is a serious disease and was responsible for 429,000 deaths in 2015. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the main clinical complications of severe malaria; it is characterized by a high mortality rate and ...
Marcelo L. M. Pereira, Claudio R. F. Marinho, Sabrina Epiphanio   +2 more
doaj   +1 more source

Heme-Protein Active Site Models via Self-Assembly in Water [PDF]

, 2016
Water-soluble models of heme-protein active sites are obtained via the self-assembly of cationic porphyrins 1 and tetrasulfonato calix[4]arene 2 (K1·2 = 105 M-1).
Kamil Wojciechowski (1907947), David N. Reinhoudt (2241391), Peter Timmerman (1801915), Matthias Wessling (1465381), Alberto Figoli (3066696), Mercedes Crego-Calama (2176518), Roberto Fiammengo (25483)   +6 more
core   +1 more source

Heme-Fe^III Superoxide, Peroxide and Hydroperoxide Thermodynamic Relationships: Fe^III-O₂^•– Complex H‑Atom Abstraction Reactivity [PDF]

, 2020
Establishing redox and thermodynamic relationships between metal-ion-bound O2 and its reduced (and protonated) derivatives is critically important for a full understanding of (bio)­chemical processes involving dioxygen processing.
Hyun Kim (127301), Patrick J. Rogler (8368395), Savita K. Sharma (1378899), Andrew W. Schaefer (184997), Kenneth D. Karlin (1326828), Edward I. Solomon (177653)   +5 more
core   +1 more source

Heme-Derived Metabolic Signals Dictate Immune Responses

Frontiers in Immunology, 2020
Heme is one of the most abundant molecules in the body acting as the functional core of hemoglobin/myoglobin involved in the O2/CO2 carrying in the blood and tissues, redox enzymes and cytochromes in mitochondria.
Giacomo Canesin, Seyed M. Hejazi, Kenneth D. Swanson, Barbara Wegiel   +3 more
doaj   +1 more source

Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages

Frontiers in Immunology, 2017
Tumor-associated macrophages (TAMs) frequently help to sustain tumor growth and mediate immune suppression in the tumor microenvironment (TME). Here, we identified a subset of iron-loaded, pro-inflammatory TAMs localized in hemorrhagic areas of the TME ...
Milene Costa da Silva, Milene Costa da Silva, Milene Costa da Silva, Milene Costa da Silva, Milene Costa da Silva, Michael O. Breckwoldt, Michael O. Breckwoldt, Francesca Vinchi, Francesca Vinchi, Margareta P. Correia, Ana Stojanovic, Carl Maximilian Thielmann, Carl Maximilian Thielmann, Michael Meister, Michael Meister, Thomas Muley, Thomas Muley, Arne Warth, Arne Warth, Michael Platten, Michael Platten, Matthias W. Hentze, Adelheid Cerwenka, Adelheid Cerwenka, Martina U. Muckenthaler, Martina U. Muckenthaler, Martina U. Muckenthaler   +26 more
doaj   +1 more source

Convenient Heme Nanorod Modified Electrode for Quercetin Sensing by Two Common Electrochemical Methods

Micromachines, 2021
Quercetin (Qu) is one of the most abundant flavonoids in the human diet. High concentrations of Qu can easily cause adverse effects and induce inflammation, joint pain and stiffness.
Jin-Guang Liu, Jia-Zheng Wan, Qing-Min Lin, Guo-Cheng Han, Xiao-Zhen Feng, Zhencheng Chen   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source