Results 41 to 50 of about 202,054 (300)
New Marker of Colon Cancer Risk Associated with Heme Intake: 1,4-Dihydroxynonane Mercapturic Acid [PDF]
, 2006 Background: Red meat consumption is associated with an increased risk of colon cancer. Animal studies show that heme, found in red meat, promotes preneoplastic lesions in the colon, probably due to the oxidative properties of this compound.
G. Gottardi +21 more
core +1 more source
The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression
mSphere, 2023 Pseudomonas aeruginosa is an opportunistic pathogen that requires iron for growth and virulence, yet this nutrient is sequestered by the innate immune system during infection. When iron is limiting, P. aeruginosa expresses the PrrF1 and PrrF2 small RNAs (
Tra-My Hoang +8 more
doaj +1 more source
Heme Oxygenase-2 Is a Hemoprotein and Binds Heme through Heme Regulatory Motifs That Are Not Involved in Heme Catalysis [PDF]
Journal of Biological Chemistry, 1997 The heme oxygenase (HO) system degrades heme to biliverdin and CO and releases chelated iron. In the primary sequence of the constitutive form, HO-2, there are three potential heme binding sites: two heme regulatory motifs (HRMs) with the absolutely conserved Cys-Pro pair, and a conserved 24-residue heme catalytic pocket with a histidine residue ...
W K, McCoubrey, T J, Huang, M D, Maines
openaire +2 more sources
Creation of novel pharmacological tools in heme oxygenase research [PDF]
, 2012 Aims: While great strides have been made in the elucidation of the physiological and pharmacological roles of heme oxygenases (HO) in experimental animals and humans, there is still an enormous potential for further research discoveries and their ...
Vukomanovic, Dragic +11 more
core +1 more source
Frontiers in Microbiology, 2020 Ferric uptake regulator (Fur) is a transcriptional regulator playing a central role in iron homeostasis of many bacteria, and Fur inactivation commonly results in pleiotropic phenotypes.
Lulu Liu +5 more
doaj +1 more source
HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children. [PDF]
, 2012 Heme oxygenase 1 (HO-1) is an essential enzyme induced by heme and multiple stimuli associated with critical illness. In humans, polymorphisms in the HMOX1 gene promoter may influence the magnitude of HO-1 expression.
Madi Njie (177625) +101 more
core +1 more source
Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection [PDF]
, 2013 Heme oxygenases (HO) catalyze the rate-limiting step of heme degradation. The cytoprotective action of the inducible HO-1 isoform, encoded by the Hmox1 gene, is required for host protection against systemic infections. Here we report that upregulation of
Larsen, Rasmus +10 more
core +1 more source
Maturation of Plastid c-type Cytochromes
Frontiers in Plant Science, 2017 Cytochromes c are hemoproteins, with the prosthetic group covalently linked to the apoprotein, which function as electron carriers. A class of cytochromes c is defined by a CXXCH heme-binding motif where the cysteines form thioether bonds with the vinyl ...
Stéphane T. Gabilly +3 more
doaj +1 more source
Endothelial TLR4 Expression Mediates Vaso-Occlusive Crisis in Sickle Cell Disease
Frontiers in Immunology, 2021 Heme, released from red blood cells in sickle cell disease (SCD), interacts with toll-like receptor 4 (TLR4) to activate NF-κB leading to the production of cytokines and adhesion molecules which promote inflammation, pain, and vaso-occlusion.
Joan D. Beckman +11 more
doaj +1 more source
, 2018 The Gram-positive pathogens Corynebacterium diphtheriae and Streptococcus pyogenes both require iron for survival. These bacteria have developed sophisticated heme uptake and transport protein machinery responsible for the import of iron into the cell ...
Draganova, Elizabeth B
core +1 more source