Results 41 to 50 of about 232,755 (310)

Heme biosynthesis and the porphyrias

Molecular Genetics and Metabolism, 2019
Porphyrias, is a general term for a group of metabolic diseases that are genetic in nature. In each specific porphyria the activity of specific enzymes in the heme biosynthetic pathway is defective and leads to accumulation of pathway intermediates ...
J. Phillips
semanticscholar   +1 more source

The macrophage heme-heme oxygenase-1 system and its role in inflammation.

Biochemical Pharmacology, 2018
Heme oxygenase (HO)-1, the inducible isoform of the heme-degrading enzyme HO, plays a critical role in inflammation and iron homeostasis. Regulatory functions of HO-1 are mediated via the catalytic breakdown of heme, which is an iron-containing ...
Vijith Vijayan, F. Wagener, S. Immenschuh   +2 more
semanticscholar   +1 more source

Heme oxygenation and the widening paradigm of heme degradation [PDF]

Archives of Biochemistry and Biophysics, 2014
Heme degradation through the action of heme oxygenase (HO) is unusual in that it utilizes heme as both a substrate and cofactor for its own degradation. HO catalyzes the oxygen-dependent degradation of heme to biliverdin with the release of CO and "free" iron.
Angela, Wilks, Geoffrey, Heinzl
openaire   +2 more sources

Maturation of Plastid c-type Cytochromes

Frontiers in Plant Science, 2017
Cytochromes c are hemoproteins, with the prosthetic group covalently linked to the apoprotein, which function as electron carriers. A class of cytochromes c is defined by a CXXCH heme-binding motif where the cysteines form thioether bonds with the vinyl ...
Stéphane T. Gabilly, Stéphane T. Gabilly, Patrice P. Hamel, Patrice P. Hamel   +3 more
doaj   +1 more source

Endothelial TLR4 Expression Mediates Vaso-Occlusive Crisis in Sickle Cell Disease

Frontiers in Immunology, 2021
Heme, released from red blood cells in sickle cell disease (SCD), interacts with toll-like receptor 4 (TLR4) to activate NF-κB leading to the production of cytokines and adhesion molecules which promote inflammation, pain, and vaso-occlusion.
Joan D. Beckman, Fuad Abdullah, Chunsheng Chen, Rachel Kirchner, Dormarie Rivera-Rodriguez, Zachary M. Kiser, Aithanh Nguyen, Ping Zhang, Julia Nguyen, Robert P. Hebbel, John D. Belcher, Gregory M. Vercellotti   +11 more
doaj   +1 more source

Could Heme Oxygenase-1 Be a New Target for Therapeutic Intervention in Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome?

Frontiers in Cellular and Infection Microbiology, 2018
Malaria is a serious disease and was responsible for 429,000 deaths in 2015. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the main clinical complications of severe malaria; it is characterized by a high mortality rate and ...
Marcelo L. M. Pereira, Claudio R. F. Marinho, Sabrina Epiphanio   +2 more
doaj   +1 more source

Heme-Derived Metabolic Signals Dictate Immune Responses

Frontiers in Immunology, 2020
Heme is one of the most abundant molecules in the body acting as the functional core of hemoglobin/myoglobin involved in the O2/CO2 carrying in the blood and tissues, redox enzymes and cytochromes in mitochondria.
Giacomo Canesin, Seyed M. Hejazi, Kenneth D. Swanson, Barbara Wegiel   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Effects of Bodypump Training on Blood Pressure and Physical Fitness in Sedentary Older Adults with Hypertension: A Randomized Trial

Physiologia
Background/Objectives: Hypertension is a leading cause of cardiovascular morbidity and mortality, particularly in older adults, pharmacological therapy is effective, but side effects and limited adherence highlight the need for non-pharmacological ...
Manuel Jesús Rodríguez Chavarría, Manuel Chavarrías-Olmedo, Jorge Pérez-Gómez   +2 more
doaj   +1 more source

Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages

Frontiers in Immunology, 2017
Tumor-associated macrophages (TAMs) frequently help to sustain tumor growth and mediate immune suppression in the tumor microenvironment (TME). Here, we identified a subset of iron-loaded, pro-inflammatory TAMs localized in hemorrhagic areas of the TME ...
Milene Costa da Silva, Milene Costa da Silva, Milene Costa da Silva, Milene Costa da Silva, Milene Costa da Silva, Michael O. Breckwoldt, Michael O. Breckwoldt, Francesca Vinchi, Francesca Vinchi, Margareta P. Correia, Ana Stojanovic, Carl Maximilian Thielmann, Carl Maximilian Thielmann, Michael Meister, Michael Meister, Thomas Muley, Thomas Muley, Arne Warth, Arne Warth, Michael Platten, Michael Platten, Matthias W. Hentze, Adelheid Cerwenka, Adelheid Cerwenka, Martina U. Muckenthaler, Martina U. Muckenthaler, Martina U. Muckenthaler   +26 more
doaj   +1 more source