Results 91 to 100 of about 202,054 (300)

The phylogeny of the mammalian heme peroxidases and the evolution of their diverse functions [PDF]

, 2008
The mammalian heme peroxidases (MHPs) are a medically important group of enzymes. Included in this group are myeloperoxidase, eosinophil peroxidase, lactoperoxidase, and thyroid peroxidase.
Ó Fágáin, Ciarán, O'Connor, B, Noeleen B Loughran, Mary J O'Connell, O\u27Connor, Brendan, O'Connell, MJ, O\u27Connell, Mary J., Brendan O'Connor, O'Connor, Brendan, Loughran, Noeleen B., Ciaran O'Fagain, O'Connell, Mary J., Loughran, NB, Ó'Fágáin, C, Loughran Noeleen B, O'Connell Mary J, Ó'Fágáin Ciarán, O'Connor Brendan   +17 more
core   +2 more sources

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Silencing of Iron and Heme-Related Genes Revealed a Paramount Role of Iron in the Physiology of the Hematophagous Vector Rhodnius prolixus

Frontiers in Genetics, 2018
Iron is an essential element for most organisms However, free iron and heme, its complex with protoporphyrin IX, can be extremely cytotoxic, due to the production of reactive oxygen species, eventually leading to oxidative stress.
Ana B. Walter-Nuno, Ana B. Walter-Nuno, Mabel L. Taracena, Mabel L. Taracena, Rafael D. Mesquita, Rafael D. Mesquita, Pedro L. Oliveira, Pedro L. Oliveira, Gabriela O. Paiva-Silva, Gabriela O. Paiva-Silva   +9 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Radical‐Mediated In Situ Fluorescence Dye Deposition: A Simple Interfacial Signal Amplification Reaction for Ultrasensitive Immunoassay on Barcode Beads

Advanced Science, EarlyView.
A radical‐mediated in situ fluorescence dye deposition (RIFD) reaction containing merely three elements of beads, dyes, and radicals is discovered for the first time, and its underlying mechanism is elucidated. This simple RIFD enables the interfacial and ultrafast deposition of free dyes onto barcode beads, serving as a powerful signal amplification ...
Jiayu Zhang, Yao Wang, Xinyi Huang, Haiyu Wu, Qiuning Lin, Hongchen Gu, Li Jiang, Linyong Zhu, Hong Xu   +8 more
wiley   +1 more source

Proposed mechanisms for free-heme-dependent potentiation of lung infection after trauma hemorrhage.

, 2018
We hypothesize that when resuscitation with stored red blood cells (RBCs) leads to increased circulating heme that is in excess of hemopexin, 2 parallel pathways are activated involving (i) release of HMGB1 and subsequent decreased immune-cell-dependent ...
Jean-Francois Pittet (254567), Angela P. Brandon (4925758), Rakesh P. Patel (308052), Shannon W. Stephens (4925773), Judy Creighton (4925776), Marisa B. Marques (721880), Jillian R. Richter (4925779), Brant M. Wagener (586587), Jeffrey D. Kerby (4925770), Cilina A. Evans (4925767), Parker J. Hu (4925764), Charity Morgan (4925761), Jaideep Honavar (412428), Joo-Yeun Oh (704641), Randal O. Dull (829904)   +14 more
core   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

MopA, the Mn Oxidizing Protein From Erythrobacter sp. SD-21, Requires Heme and NAD+ for Mn(II) Oxidation

Frontiers in Microbiology, 2018
Bacterial manganese (Mn) oxidation is catalyzed by a diverse group of microbes and can affect the fate of other elements in the environment. Yet, we understand little about the enzymes that catalyze this reaction.
Michael Medina, Antonia Rizo, David Dinh, Briana Chau, Moussa Omidvar, Andrew Juarez, Julia Ngo, Hope A. Johnson   +7 more
doaj   +1 more source

Heme-Protein Active Site Models via Self-Assembly in Water

, 2016
Water-soluble models of heme-protein active sites are obtained via the self-assembly of cationic porphyrins 1 and tetrasulfonato calix[4]arene 2 (K1·2 = 105 M-1).
Kamil Wojciechowski (1907947), David N. Reinhoudt (2241391), Peter Timmerman (1801915), Matthias Wessling (1465381), Alberto Figoli (3066696), Mercedes Crego-Calama (2176518), Roberto Fiammengo (25483)   +6 more
core   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source