Results 131 to 140 of about 428,654 (353)
Advanced Science, EarlyView.BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang +9 more
wiley +1 more source
Ideals generated by submaximal minors [PDF]
, 2008 The goal of this paper is to study irreducible families W(b;a) of codimension 4, arithmetically Gorenstein schemes X of P^n defined by the submaximal minors of a t x t matrix A with entries homogeneous forms of degree a_j-b_i.
Kleppe, Jan O., Miro-Roig, Rosa M.
core +2 more sources
Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis
Cell Death and Differentiation, 2017 Heme is required for cell respiration and survival. Nevertheless, its intracellular levels need to be finely regulated to avoid heme excess, which may catalyze the production of reactive oxygen species (ROS) and promote cell death.
S. Petrillo +12 more
semanticscholar +1 more source
A Dynamic Gate Enables Regioselective Hydroxylation of Free Arginine by a Non‐Canonical Heme Enzyme
Advanced Science, EarlyView.The YqcI/YcgG enzyme AglA employs a unique “sandwich” fold and a dynamic gating mechanism to selectively hydroxylate AMPn‐Arg at Nε. Site‐directed mutations reprogram regioselectivity or enable activity on free arginine by altering hydrogen‐bond networks, precisely positioning substrates.
Yuan Sun +12 more
wiley +1 more source
A Comparison of Pathophysiology in Humans and Rodent Models of Subarachnoid Hemorrhage
Frontiers in Molecular Neuroscience, 2018 Non-traumatic subarachnoid hemorrhage (SAH) affects an estimated 30,000 people each year in the United States, with an overall mortality of ~30%. Most cases of SAH result from a ruptured intracranial aneurysm, require long hospital stays, and result in ...
Jenna L. Leclerc +10 more
doaj +1 more source
Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling. [PDF]
, 2018 BACKGROUND:Human cerebral malaria (HCM) is a severe form of malaria characterized by sequestration of infected erythrocytes (IRBCs) in brain microvessels, increased levels of circulating free heme and pro-inflammatory cytokines and chemokines, brain ...
Cespedes, Juan Carlos +5 more
core +1 more source
Nrf2, a Cap’n’Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene*
Journal of Biological Chemistry, 1999 Stress response elements, which mediate induction of the mouse heme oxygenase-1 (HO-1) gene by several agents, resemble the binding site for the activator protein-1 (Jun/Fos), Maf, and Cap’n’Collar/basic leucine zipper (CNC-bZIP) families of proteins. In
J. Alam +5 more
semanticscholar +1 more source
ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling
Advanced Science, EarlyView.ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao +19 more
wiley +1 more source
The GluTR-binding protein is the heme-binding factor for feedback control of glutamyl-tRNA reductase
eLife, 2019 Synthesis of 5-aminolevulinic acid (ALA) is the rate-limiting step in tetrapyrrole biosynthesis in land plants. In photosynthetic eukaryotes and many bacteria, glutamyl-tRNA reductase (GluTR) is the most tightly controlled enzyme upstream of ALA.
Andreas S Richter +2 more
doaj +1 more source
Advanced Science, EarlyView.Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi +10 more
wiley +1 more source