Results 121 to 130 of about 207,281 (307)
Combining experiment and energy landscapes to explore anaerobic heme breakdown in multifunctional hemoproteins [PDF]
To survive, many pathogens extract heme from their host organism and break down the porphyrin scaffold to sequester the Fe2+ ion via a heme oxygenase. Recent studies have revealed that certain pathogens can anaerobically degrade heme.
Yuhang Xie +8 more
core +1 more source
Apomyoglobin Sequesters Heme from Heme Bound Aβ Peptides
, 2016 A combination of absorption, electron paramagnetic resonance (EPR), and resonance Raman (rR) spectroscopy has been used to study the interaction of heme-Aβ and apomyoglobin (apoMb).
Debajyoti Pramanik (1902628) +2 more
core +1 more source
Genetic Diversity, Adaptation, Wild Introgression, and Coat Color Mutation of Golden Yak
Animal Research and One Health, EarlyView.Genetic diversity, adaptation, wild introgression, and coat color mutation of golden yak from two populations on the Qinghai‐Xizang Plateau. ABSTRACT The golden yak lives on the Qinghai‐Xizang Plateau with a golden coat and adapts to high altitudes and strong ultraviolet environment. The golden coat is a prominent phenotype in many domesticated species,
Huixuan Yan +15 more
wiley +1 more source
Charged Amino Acid Substitutions Affect Conformation of Neuroglobin and Cytochrome c Heme Groups
Current Issues in Molecular BiologyNeuroglobin (Ngb) is a cytosolic heme protein that plays an important role in protecting cells from apoptosis through interaction with oxidized cytochrome c (Cyt c) released from mitochondria.
Marina A. Semenova +7 more
doaj +1 more source
Animal Research and One Health, EarlyView.This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen +2 more
wiley +1 more source
Animal Research and One Health, EarlyView.Multifunctional roles of functional amino acids in regulating meat quality in ruminants: Functional amino acids (FAAs) regulate ruminant meat quality through multiple interconnected mechanisms, including antioxidant protection, metabolic regulation, signal transduction, structural support, and gene expression modulation.
Zixin Liu +5 more
wiley +1 more source
Regulation of heme biosynthesis via the coproporphyrin dependent pathway in bacteria
Frontiers in MicrobiologyHeme biosynthesis in the Gram-positive bacteria occurs mostly via a pathway that is distinct from that of eukaryotes and Gram-negative bacteria in the three terminal heme synthesis steps.
Hadia Aftab, Rebecca K. Donegan
doaj +1 more source
Distinct Molecular Pathways Supporting Sjögren Disease Clusters and Disease Progression
Arthritis &Rheumatology, EarlyView.Objective Sjögren disease (SjD) is a heterogeneous autoimmune disease. We aimed to investigate blood transcriptomic signatures and disease progression among three recently defined clusters of patients with SjD: (1) B cell active disease with low symptom burden (BALS), (2) high systemic activity (HSA), and (3) low systemic activity with high symptom ...
Sacha E. Silva‐Saffar +6 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective The gut–joint axis is a central paradigm in spondyloarthritis, yet the cellular mechanisms linking intestinal and joint immunity remain poorly understood. One potential link is T cell receptor αβ+ CD4+ colon intraepithelial lymphocytes (cIELs) that can traffic to extraintestinal tissues, including the joint.
Sarah M. Danielson +4 more
wiley +1 more source