Results 141 to 150 of about 202,054 (300)

Charged Amino Acid Substitutions Affect Conformation of Neuroglobin and Cytochrome c Heme Groups

Current Issues in Molecular Biology
Neuroglobin (Ngb) is a cytosolic heme protein that plays an important role in protecting cells from apoptosis through interaction with oxidized cytochrome c (Cyt c) released from mitochondria.
Marina A. Semenova, Zhanna V. Bochkova, Olga M. Smirnova, Georgy V. Maksimov, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh, Nadezda A. Brazhe, Rita V. Chertkova   +7 more
doaj   +1 more source

Regulation of heme biosynthesis via the coproporphyrin dependent pathway in bacteria

Frontiers in Microbiology
Heme biosynthesis in the Gram-positive bacteria occurs mostly via a pathway that is distinct from that of eukaryotes and Gram-negative bacteria in the three terminal heme synthesis steps.
Hadia Aftab, Rebecca K. Donegan
doaj   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Editorial: Complement: Latest developments regarding structure, mechanism, and connections to other proteolytic pathways

Frontiers in Immunology, 2023
József Dobó, Péter Gál, Brian V. Geisbrecht   +2 more
doaj   +1 more source

Synthesis, X-ray Crystal Structure, and Solution Behavior of Fe(NO)₂(1-MeIm)₂:  Implications for Nitrosyl Non-Heme-Iron Complexes with g = 2.03

, 2016
Synthesis, X-ray Crystal Structure, and Solution Behavior of Fe(NO)2(1-MeIm)2:  Implications for Nitrosyl Non-Heme-Iron Complexes with g = 2 ...
Nada Reginato (3005598), Dmitry Pervitsky (2369920), Christopher T. C. McCrory (3005595), Lijuan Li (520658)   +3 more
core   +1 more source

Malaria and susceptibility to other infections [PDF]

Malaria is widely perceived as immunosuppressive. Despite extensive phenomenological description, the underlying mechanisms remain poorly described. The aim of this thesis was to identify possible mechanisms by which malaria modifies host defence, and
Cunnington, Aubrey Justin
core   +1 more source

Targeting heme in sickle cell disease: new perspectives on priapism treatment

Frontiers in Physiology
Men with sickle cell disease (SCD) frequently experience priapism, defined as prolonged, painful erections occurring without sexual arousal or desire. This urological emergency can lead to penile fibrosis and permanent erectile dysfunction if not treated
Tammyris Helena Rebecchi Silveira, Fabiano Beraldi Calmasini, Mariana Gonçalves de Oliveira, Fernando Ferreira Costa, Fábio Henrique Silva   +4 more
doaj   +1 more source

Loss of the putative Rab GTPase, Ypt7, impairs the virulence of Cryptococcus neoformans

Frontiers in Microbiology
Small GTPases of the Rab family coordinate multiple membrane fusion and trafficking events in eukaryotes. In fungi, the Rab GTPase, Ypt7, plays a critical role in late endosomal trafficking, and is required for homotypic fusion events in vacuole ...
Guanggan Hu, Xianya Qu, Xianya Qu, Kabir Bhalla, Kabir Bhalla, Peng Xue, Erik Bakkeren, Erik Bakkeren, Christopher W. J. Lee, Christopher W. J. Lee, James W. Kronstad, James W. Kronstad   +11 more
doaj   +1 more source

HssS activation by membrane heme defines a paradigm for two-component system signaling in Staphylococcus aureus

International audienceABSTRACT Strict management of intracellular heme pools, which are both toxic and beneficial, is crucial for bacterial survival during infection.
Arnoux, Pascal, Siponen, Marina, Boëton, Pierre, Saillant, Vincent, Lipuma, Damien, Morey, Léo, Lechardeur, Delphine   +6 more
core   +1 more source

Genetic Diversity, Adaptation, Wild Introgression, and Coat Color Mutation of Golden Yak

Animal Research and One Health, EarlyView.
Genetic diversity, adaptation, wild introgression, and coat color mutation of golden yak from two populations on the Qinghai‐Xizang Plateau. ABSTRACT The golden yak lives on the Qinghai‐Xizang Plateau with a golden coat and adapts to high altitudes and strong ultraviolet environment. The golden coat is a prominent phenotype in many domesticated species,
Huixuan Yan, Jialei Chen, Chuzhao Lei, Fengwei Zhang, Shunzhong He, Weiru Song, Hongyan Ma, Shuling Li, Guomei Li, Laba Yongcuo, Jianlin Han, Johannes A. Lenstra, Qiang Zhang, Rende Song, Basang Wangdui, Ningbo Chen   +15 more
wiley   +1 more source