Results 131 to 140 of about 207,281 (307)

HssS activation by membrane heme defines a paradigm for two-component system signaling in Staphylococcus aureus

International audienceABSTRACT Strict management of intracellular heme pools, which are both toxic and beneficial, is crucial for bacterial survival during infection.
Arnoux, Pascal, Siponen, Marina, Boëton, Pierre, Saillant, Vincent, Lipuma, Damien, Morey, Léo, Lechardeur, Delphine   +6 more
core   +1 more source

Hemoglobin and heme scavenging

, 2005
Release of hemoglobin into plasma is a physiological phenomenon associated with intravascular hemolysis. In plasma, stable haptoglobin-hemoglobin complexes are formed and these are subsequently delivered to the reticulo-endothelial system by CD163 ...
T. Beringhelli, P. Visca, M. Fasano, E. Tolosano, P. Ascenzi, F. Altruda, A. Bocedi   +6 more
core   +1 more source

Homologous tumor‐targeting biomimetic nanozyme for synergistic NIR‐II photothermal and chemodynamic therapy

BMEMat, EarlyView.
Studies reveal that a biomimetic nanoplatform based on a cancer cell membrane‐camouflaged Au‐MnOx nanozyme (Au‐MnOx@CCM) can achieve synergistic antitumor therapy by combining NIR‐II mediated PTT with enhanced CDT, offering a promising strategy for precise and efficient tumor therapy. Abstract The therapeutic potential of nanozyme‐mediated chemodynamic
Xiaonan Li, Siman Luo, Yucheng Zuo, Liheng Chen, Houjuan Zhu, Jing‐Yi Zhu, Wei Xue   +6 more
wiley   +1 more source

Ligand probes for heme proteins

, 2005
Heme-containing proteins are one of the most structurally and functionally diverse groups of proteins in nature. Central to our understanding of their function is an appreciation of the fundamental inorganic and physical properties of the heme prosthetic
Chapman, SK, Chapman, Stephen K, Anderson, J L Ross, Anderson, J L R   +3 more
core   +1 more source

An all‐in‐one fucosylated gold nanocluster probe enables NIR‐II imaging and multi‐mechanistic therapy of acute kidney injury

BMEMat, EarlyView.
This study developed a fucoside‐targeted gold nanocluster probe that enables early NIR‐II imaging and multi‐mechanistic therapy for acute kidney injury, effectively mitigating oxidative stress, modulating inflammatory responses, and inhibiting ferroptosis to improve renal outcomes. Abstract Acute kidney injury (AKI) remains a life‐threatening condition
Ping Zhang, Boning Tan, Suqing Feng, Beibei Gu, Ting Feng, Haiguang Zhu, Jianping Xie, Xun Yuan   +7 more
wiley   +1 more source

Targeting heme in sickle cell disease: new perspectives on priapism treatment

Frontiers in Physiology
Men with sickle cell disease (SCD) frequently experience priapism, defined as prolonged, painful erections occurring without sexual arousal or desire. This urological emergency can lead to penile fibrosis and permanent erectile dysfunction if not treated
Tammyris Helena Rebecchi Silveira, Fabiano Beraldi Calmasini, Mariana Gonçalves de Oliveira, Fernando Ferreira Costa, Fábio Henrique Silva   +4 more
doaj   +1 more source

A bioinspired catalytic nanoplatform for ferroptosis‐immunotherapy synergy in metastatic cancer

BMEMat, EarlyView.
The bioinspired nanoplatform MnMSN@MnP‐PEG co‐delivers manganese peroxidase and manganese ions to synergistically induce immunogenic ferroptosis and activate the cGAS‐STING pathway, eliciting potent antitumor immunity against primary and metastatic tumors.
Panpan Xue, Hai Cai, Ying Sun, Yaxin Ma, Siyuan Liu, Jinying Zhu, Yan Chen, Xuemei Zeng, Shuangqian Yan   +8 more
wiley   +1 more source

Loss of the putative Rab GTPase, Ypt7, impairs the virulence of Cryptococcus neoformans

Frontiers in Microbiology
Small GTPases of the Rab family coordinate multiple membrane fusion and trafficking events in eukaryotes. In fungi, the Rab GTPase, Ypt7, plays a critical role in late endosomal trafficking, and is required for homotypic fusion events in vacuole ...
Guanggan Hu, Xianya Qu, Xianya Qu, Kabir Bhalla, Kabir Bhalla, Peng Xue, Erik Bakkeren, Erik Bakkeren, Christopher W. J. Lee, Christopher W. J. Lee, James W. Kronstad, James W. Kronstad   +11 more
doaj   +1 more source

Small scale purification and biophysical characterization of haptoglobin derived from human Cohn fraction IV

Biotechnology Progress, EarlyView.
Abstract Haptoglobin (Hp) is a polymorphic acute phase α‐2 glycoprotein found in plasma that plays a critical role in binding, neutralizing, and removing cell‐free hemoglobin (Hb) from the circulation. Under clinical conditions characterized by high levels of hemolysis, such as in patients with sickle cell disease (SCD), large quantities of cell‐free ...
Shuwei Lu, Mohd Asim Khan, Pedro Cabrales, David C. Irwin, Paul W. Buehler, Andre F. Palmer   +5 more
wiley   +1 more source

Synthesis, X-ray Crystal Structure, and Solution Behavior of Fe(NO)₂(1-MeIm)₂:  Implications for Nitrosyl Non-Heme-Iron Complexes with g = 2.03

, 2016
Synthesis, X-ray Crystal Structure, and Solution Behavior of Fe(NO)2(1-MeIm)2:  Implications for Nitrosyl Non-Heme-Iron Complexes with g = 2 ...
Nada Reginato (3005598), Dmitry Pervitsky (2369920), Christopher T. C. McCrory (3005595), Lijuan Li (520658)   +3 more
core   +1 more source