Results 201 to 210 of about 153,280 (319)

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

Medicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023
Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman, Pablo Duarte, Esteban Dauden, Antonio Cuadrado, María Isabel Rodríguez‐Franco, Manuela G. López, Rafael León   +6 more
wiley   +1 more source

The Enzymatic Degradation of Heme Proteins into Bile Pigments. III

, 1961
Hiroshi Nakajima, Tsutomu TAKEMURA, Osamu Nakajima, Kenji Yamaoka   +3 more
openalex   +2 more sources

An Iron‐Catalyzed Sustainable Functional Group Transfer Strategy for In‐Water Transformation of Organic Sulfides to Sulfoxides by a Hydroxylamine‐Derived Oxidant

ChemSusChem, EarlyView.
An iron‐catalyzed ecofriendly reaction protocol is demonstrated to chemoselectively convert readily available organic sulfides to valuable sulfoxides, under mild reaction conditions in water. The functional group tolerance, scalability, reaction compatibility, and potential application make the protocol highly attractive in terms of green and ...
Arya Singh, Yashdeep Maurya, Akhilesh Sharma, Swetha Vasanthdamodar Sivapreetha, Mehar Ul Nisa, Vishal Kumar, Puneet Gupta, Kartikay Tyagi, Sayanti Chatterjee   +8 more
wiley   +1 more source

Frataxin deficiency alters gene expression in Friedreich ataxia derived IPSC‐neurons and cardiomyocytes

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
FA is a progressive neurodegenerative disorder, but the primary cause of death is heart disease which occurs in 60% of the patients. Several functions of frataxin have been proposed, but none of them fully explain why its deficiency causes the FA phenotypes nor why the most affected cell types are neurons and cardiomyocytes.
Mariana B. Angulo, Alexander Bertalovitz, Mariana A. Argenziano, Jiajia Yang, Aarti Patel, Theresa Zesiewicz, Thomas V. McDonald   +6 more
wiley   +1 more source

The Enzymatic Degradation of Heme Proteins into Bile Pigments. V

, 1961
Hiroshi Nakajima, Tsutomu TAKEMURA, Osamu Nakajima, Kenji Yamaoka   +3 more
openalex   +2 more sources

Transforming a Historical Chemical Synthetic Route for Vanillin Starting from Renewable Eugenol to a Cell‐Free Bi‐Enzymatic Cascade

ChemSusChem, EarlyView.
An artificial enzymatic cascade to access natural vanillin from eugenol/clove oil was developed by revisiting the very first vanillin synthetic process from 19th century. The biosynthetic route consists of just two biocatalysts used as cell‐free preparation and molecular oxygen as oxidizing agent, outperforming also the natural microbial pathway which ...
Elisa Lanfranchi, Valerio Ferrario, Somayyeh Gandomkar, Stefan E. Payer, Erna Zukic, Haris Rudalija, Alexandra Musi, Ines Gaberscek, Yuliya Orel, Doreen Schachtschabel, Christian Willrodt, Michael Breuer, Wolfgang Kroutil   +12 more
wiley   +1 more source

Transcriptomic atlas reveals organ-specific disease tolerance in sickle cell mice. [PDF]

Blood Adv
Grunenwald A, Peliconi J, Lavergne J, Revel M, Voilin E, Robe-Rybkine T, Crambert G, Dimitrov JD, Blanc-Brude O, Roumenina LT.   +9 more
europepmc   +1 more source

The Enzymatic Degradation of Heme Proteins into Bile Pigments. IV

, 1961
Hiroshi Nakajima, Tsutomu TAKEMURA, Osamu Nakajima, Kenji Yamaoka   +3 more
openalex   +2 more sources

The transcriptional profile of iron deficiency in patients with heart failure: Heme‐sparing and reduced immune processes

European Journal of Heart Failure, EarlyView.
The analysis workflow, findings and potential clinical consequences of iron deficiency in heart failure (HF). From 881 patients with worsening HF, whole blood transcriptome was analysed using the Affymetrix Human Transcriptome Array (HTA) 2.0. Subjects were stratified according to their transferrin saturation (TSAT) levels as iron‐deficient (TSAT <20%)
Niels Grote Beverborg, Ridha I.S. Alnuwaysir, George Markousis‐Mavrogenis, Martijn F. Hoes, Haye H. van der Wal, Simon P.R. Romaine, Mintu Nath, Andrea Koekoemoer, John G.F. Cleland, Chim C. Lang, Stefan D. Anker, Kenneth Dickstein, Marco Metra, Leong L. Ng, Dirk J. van Veldhuisen, Adriaan A. Voors, Nilesh J. Samani, Peter van der Meer   +17 more
wiley   +1 more source

Heme delivery into soluble guanylyl cyclase requires a heme redox change and is regulated by NO and Hsp90 by distinct mechanisms. [PDF]

J Biol Chem
Dai Y, Stuehr DJ.
europepmc   +1 more source