Results 191 to 200 of about 232,755 (310)

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.

Blood, 2016
F. Vinchi, Milene Costa da Silva, G. Ingoglia, S. Petrillo, Nathan Brinkman, A. Zuercher, A. Cerwenka, E. Tolosano, M. Muckenthaler   +8 more
semanticscholar   +1 more source

Plasma heme pool compartmentalization is linked to pathophysiology in Sickle Cell Disease. [PDF]

PLoS One
Saxenhofer M, Couto D, Perez SM, Illi M, Brodard J, Njue L, Chanias I, Medri C, Tsilimidos G, Hadorn N, Chirlias C, Mesquita AB, Veuthey L, Schnell A, Graeter S, Kato GJ, Adam J, Merki R, Levrat E, Samii K, Keiser M, Bieri KS, Haynes AG, Angelillo-Scherrer A, Alberio L, Grandoni F, Gavillet M, Gentinetta T, Rovó A, Schaub A.   +29 more
europepmc   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Meat Intake and Risk of Gastric and Esophageal Adenocarcinoma in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study

International Journal of Cancer, EarlyView.
Limited evidence links processed meat intake and non‐cardia gastric cancer, while esophageal adenocarcinoma is increasing in Western countries, where diets are typically high in red and processed meats. Using data from over 450,000 participants from a large prospective study, the authors examined meat consumption and the risk of gastric and esophageal ...
Catalina Bonet, Lucía Rizzolo‐Brime, Sara Montañés, Mariem Hajji, Chloé Marques, Gianluca Severi, Matthias B Schulze, Christina C. Dahm, Anne Tjønneland, Anja Olsen, Maria S. De Magistris, Valeria Pala, Alberto Catalano, Guri Skeie, Magritt Brustad, Torill Enget Jensen, Maria‐José Sánchez, Marcela Guevara, Natalia Cabrera Castro, Keren Papier, Elisabete Weiderpass, Viktoria Knaze, Jin Young Park, Gwen Murphy, Antonio Agudo, Paula Jakszyn   +25 more
wiley   +1 more source

Heme Metabolism-Derived Carbon Monoxide Regulates Skeletal Muscle Function. [PDF]

J Cachexia Sarcopenia Muscle
Alves de Souza RW, In Kim H, Alves PKN, da Paixão AO, Rasmussen A, Shankar S, Harbison J, Voltarelli VA, Otterbein LE.   +8 more
europepmc   +1 more source

Heme Oxygenases in Cardiovascular Health and Disease.

Physiological Reviews, 2016
Anita Ayer, Abolfazl Zarjou, A. Agarwal, R. Stocker   +3 more
semanticscholar   +1 more source

Decidual macrophage‐mediated ferroptosis in trophoblasts leads to recurrent spontaneous abortion

iMeta, EarlyView.
Decidual macrophages from recurrent spontaneous abortion (RSA) patients promote trophoblast ferroptosis and impair trophoblast cell function. Mechanistically, the CXCL2/NF‐κB/HMOX1 axis mediates this effect. Conversely, trophoblasts co‐cultured with RSA decidual macrophages induce pro‐inflammatory macrophage polarization through IL‐6/JAK2/STAT3 ...
Xin Chen, Xueqin Ma, Pengcheng Pang, Heng Zhou, Ruohan Li, Yan He, Yan Zhang, Jing Yang, Qianlin Song, Qingsong Ye   +9 more
wiley   +1 more source

Heme arginate improves acute liver failure secondary to erythropoietic protoporphyria: a case report. [PDF]

Front Med (Lausanne)
Ni H, Chen B, Huang A, Zhang T, Li H, Tang S.   +5 more
europepmc   +1 more source

Protective Role of Polydatin Against Vancomycin‐Induced Lung Toxicity via Oxidative Stress, Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Ferroptosis Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate whether polydatin (Poly) could eliminate the harmful effects of vancomycin (VCM) on the lungs of rats. Rats were administered VCM (200 mg/kg) and Poly (50 mg/kg), both separately and in combination, for a duration of 7 days.
Serpil Aygörmez, Sefa Küçükler, Selim Çomaklı, Hasan Şimşek, Özge Kandemir, Fatih Mehmet Kandemir, Şaban Maraşlı   +6 more
wiley   +1 more source

Apohemoglobin-haptoglobin complex is a therapeutic against vaso-occlusive crisis: scavenging of hemoglobin and heme. [PDF]

Blood Adv
Munoz CJ, Pires IS, Lucas D, Muller C, Martinez J, Gopal S, Palmer AF, Cabrales P.   +7 more
europepmc   +1 more source