Results 171 to 180 of about 207,281 (307)

Artificial Intelligence‐Assisted Strategies for KEAP1 Modulator Discovery: From Virtual Screening to De Novo Molecular Design

iNew Medicine, EarlyView.
KEAP1 represents a promising target for regulating oxidative‐stress‐associated diseases. AI approaches accelerate KEAP1 inhibitor discovery through structure prediction and virtual screening. Integrated computational and experimental platforms facilitate translational development.
Feilong Zhou, Qiansong Chen, Xing Chen, Baoan Song, Xinhua Liu   +4 more
wiley   +1 more source

Heme-Binding Groups in Cytochrome P450 Inhibitors: Coordination Mechanisms, Evidence Standards and Implications for CYP19A1 Ligand Design. [PDF]

Molecules
Kozyra P, Masłyk M.
europepmc   +1 more source

Hematological and Genotoxic Effects of Subchronic Oral Exposure to a Mancozeb‐Based Fungicide in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The extensive use of pesticides in modern agriculture has raised increasing concerns regarding the potential biological effects of repeated exposure to pesticide residues and commercial formulations. Mancozeb is a widely used ethylene‐bis‐dithiocarbamate fungicide; however, information on its hematological and genotoxic effects following ...
Matheus Henrique Barcelos Figueiredo, Natanael Vaz Crisóstomo Peixoto, Paula Soares Nakamura, Cecília Müller Wodzik, Lucas Ribeiro Maia dos Santos, Fábio Vieira de Andrade Borges, Lara Cândida de Sousa Machado, Jéssica Gardone Vitório, Renata Mazaro e Costa, Mônica Rodrigues Ferreira Machado, Walter Dias Júnior   +10 more
wiley   +1 more source

The DAMP Awakens: The Role of Heme and Heme Oxygenase-1 in Organ Transplantation. [PDF]

Biomolecules
Wagner T, Thomas MN, Otterbein LE.
europepmc   +1 more source

Exposure–Recovery Approach for Hepatic Toxicity Analysis of Pyrethroid Lambda‐Cyhalothrin: Histopathological, Histochemical, and Biochemical Responses in Oreochromis niloticus

Journal of Applied Toxicology, EarlyView.
ABSTRACT Lambda‐cyhalothrin is a synthetic pyrethroid insecticide widely used in agriculture, but its potential to contaminate aquatic ecosystems and exert high toxicity on fish at low concentrations raises ecotoxicological concerns. While standard histopathological and biochemical assessments are common, the novel integration of pigment‐based ...
Carlos Eurico Fernandes, André Luiz do Nascimento Silva, Tiago Venancio da Silva, Karine Nathiele Nogueira Farias, Sabrina Fuzer Gonçalves, Brenda de Oliveira Martins, Maria Eduarda Corona Garcia, Lilian Franco‐Belussi   +7 more
wiley   +1 more source

Regulation of free heme and heme buffering in Saccharomyces cerevisiae. [PDF]

J Biol Chem
Willoughby MM, Fu Y, Moore CM, Lee Y, Kareti MS, Wu L, Zhang L, Reddi AR.   +7 more
europepmc   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

High‐Content Screening Comparison of 1R6F Cigarette Smoke Extract and Selected Heated Tobacco and Electronic Vapour Product Aerosol Extracts in Endothelial and Bronchial Epithelial Cell Models

Journal of Applied Toxicology, EarlyView.
ABSTRACT Cigarettes induce oxidative stress and DNA damage, processes that contribute to cardiovascular and pulmonary disease. High content screening (HCS) is an increasingly valuable tool for comparative toxicology because it enables simultaneous quantification of multiple mechanistic endpoints at single‐cell resolution. In this study, HCS was used to
Edgar Trelles Sticken, Konstantinos Papikinos, Fiona Chapman, Roman Wieczorek, Sarah Jean Pour, Torge Evenburg, Sandra Otte, Tiandan Wu, Liam Simms, Matthew Stevenson   +9 more
wiley   +1 more source

Electronic Structures and Orbital Interactions of Iron Porphyrin Intermediates Throughout Electrochemical CO2 Reduction Reaction: A Computational Study

Journal of the Chinese Chemical Society, EarlyView.
Electronic structure and orbital interactions of intermediates throughout electrochemically catalyzed CO2‐to‐CO reduction reaction by iron porphyrin are carefully discussed by DFT calculations in this work. The results demonstrate distinct functions of Fe 3d orbitals and porphyrin π* orbitals for electron transfer process to CO2, and the electronic ...
Ching‐Chin Chen
wiley   +1 more source

Heme-Catalyzed Dityrosine Formation and Serotonin Oxidation in the Presence of Insulin. [PDF]

JACS Au
Pal P, Roy M, Dey C, Khan A, Dey SG.
europepmc   +1 more source