Results 221 to 230 of about 414,309 (352)

Heme Synthesis and Acquisition in Bacterial Pathogens.

Journal of Molecular Biology, 2016
Jacob E. Choby, Eric P. Skaar
semanticscholar   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Heme disposal inside heart transplants: a trigger for rejection? [PDF]

J Clin Invest
Liao F, Gelman AE.
europepmc   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

Structural basis for substrate-dependent allostery in oxygen activation by a cytochrome P450 enzyme revealed by analysis at different temperatures. [PDF]

Chem Sci
Podgorski MN, McDougal DP, Campbell EC, Bruning JB, Bell SG.   +4 more
europepmc   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Heme and hemozoin induce platelet cell death through UPR-induced apoptosis and ferroptosis in vivax malaria. [PDF]

Blood Adv
Gomes MT, Medeiros-de-Moraes IM, Vieira-de-Abreu A, de Azevedo-Quintanilha IG, Fontes TM, de Brito Carneiro A, Azambuja P, Tolley ND, Rowley JW, Carpinter BA, Ferreira MU, Gonçalves RM, Rocha VN, Rosa Nascimento AL, Carvalho WA, Scopel KKG, Campbell RA, Bozza PT, Weyrich AS, Zimmerman GA, Lacerda MVG, Castro-Faria-Neto HC, Hottz ED.   +22 more
europepmc   +1 more source

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.

Blood, 2016
F. Vinchi, Milene Costa da Silva, G. Ingoglia, S. Petrillo, Nathan Brinkman, A. Zuercher, A. Cerwenka, E. Tolosano, M. Muckenthaler   +8 more
semanticscholar   +1 more source

Advanced Interpretation of Field Cycling NMR Relaxometry Dispersion Profiles From Hard and Soft Materials

Magnetic Resonance in Chemistry, EarlyView.
This review demonstrates that NMR dispersion profiles from fast field cycling NMR relaxometry can be interpreted with the 3‐Tau model for a broad spectrum of soft and hard materials. Meaningful physical quantities provide insight into surface chemistry, bound water density, pore size, aqueous or solid iron (III) density and the free water diffusion ...
David A. Faux, Rémi Kogon
wiley   +1 more source

Comprehensive analysis of complement activation in a hydroxyurea-treated patient cohort with sickle cell disease. [PDF]

Blood Adv
Diatlov D, Bohorquez-Hernandez A, Kirby-Allen M, Licht C.   +3 more
europepmc   +1 more source