Results 221 to 230 of about 339,218 (339)

Study on the Screening of Anti‐Osteoporosis Components in Processed Epimedium‐Based on Spectrum‐Effect Analysis

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT Epimedium (EP) is a traditional Chinese medicine that has been used to treat osteoporosis for several years, but its mechanism of action is unclear. We used ultrahigh‐performance liquid chromatography coupled with triple–quadrupole mass spectrometry (UPLC–QQQ–MS/MS) to detect the components of raw and processed EP samples.
Jinling Liang   +8 more
wiley   +1 more source

FapR regulates HssRS-mediated heme homeostasis in <i>Bacillus anthracis</i>. [PDF]

open access: yesmBio
Pi H   +7 more
europepmc   +1 more source

2‐oxoglutarate analogue‐based biomolecular tools for exploring structure‐activity relationships in non‐heme iron enzymes

open access: yesChemBioChem, Accepted Article.
2‐oxoglutarate (2OG)‐dependent non‐heme iron (NHFe) enzymes constitute a family of enzymes that use 2OG and oxygen to catalyze the hydroxylation of unactivated C(sp3)–H bonds. These enzymes are of biological importance and therapeutic interest due to their role in regulating various cellular processes. Herein, we have rationally designed two classes of
Peter Windsor   +3 more
wiley   +1 more source

In Vivo Biosynthesis and Direct Incorporation of Non‐Canonical Amino Acids into Proteins

open access: yesChemBioChem, Accepted Article.
Autonomous cells are engineered biological systems capable of biosynthesising and directly incorporating non‐canonical amino acids (ncAAs) into proteins. These systems have the potential to extend the applicability of the genetic code to enable large‐scale fermentative production of proteins carrying ncAAs.
Ivana Drienovska   +2 more
wiley   +1 more source

Exceptional Heme Tolerance in <i>Serratia plymuthica</i>: Proteomic Insights into Oxidative Stress Adaptation in the <i>Aedes aegypti</i> Midgut. [PDF]

open access: yesLife (Basel)
Machado SDH   +8 more
europepmc   +1 more source

Identification of a l‐Threonine‐Utilizing Hydrazine Synthetase for Thrazarine Biosynthesis in Streptomyces coerulescens MH802‐fF5

open access: yesChemBioChem, EarlyView.
A putative thrazarine biosynthetic gene cluster is discovered in the genome sequence of Streptomyces coerulescens MH802‐fF5. In vivo and in vitro analyses of ThzN, a hydrazine synthetase with cupin and methionyl‐tRNA synthetase‐like domains encoded in the cluster, showed that it synthesizes a key intermediate of thrazarine by catalyzing condensation ...
Yusuke Shikai   +4 more
wiley   +1 more source

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