Results 231 to 240 of about 232,755 (310)

β‐Aminoisobutyric Acid Alleviates Cisplatin‐Induced Muscle Atrophy by Regulating E3 Ubiquitin Ligases, Apoptosis, Amino Acid Metabolism, Autophagy, and Ferroptosis

Medicine Bulletin, EarlyView.
ABSTRACT Background Cisplatin (CIS) is a widely used broad‐spectrum anticancer agent, but its clinical application is often limited by severe adverse effects, including skeletal muscle atrophy, which compromises patients' quality of life and treatment efficacy.
Hao‐Zhe Wang, Wen‐Bi He, Huan Wang, Hao Wang, Wen‐Jun Fang, Meng‐Qian Li, Jiong‐Xing Huang, Fei‐Peng Chen, Hui‐Guo Wang, Lin Zhu, Xiao‐Guang Liu   +10 more
wiley   +1 more source

How Does Tuning of the Primary Coordination Sphere Around Ferryl-Oxo Intermediates Affect Structure and Reactivity? Insights into Axial and Equatorial Ligand Field Effects. [PDF]

JACS Au
Mukherjee G, Panwar P, Sastri CV, Satpathy JK, de Visser SP.   +4 more
europepmc   +1 more source

The oxygen‐sensing FixLJ represses nitrogen fixation in Rhodopseudomonas palustris in response to oxygen

mLife, EarlyView.
Abstract Biological nitrogen fixation in symbiotic diazotrophs is subject to oxygen regulation by an oxygen‐sensing FixLJ two‐component system under micro‐oxic conditions. However, it remains unclear whether this mechanism is conserved in free‐living diazotrophs.
Lingwei Cui, Yan Zeng, Mengmei Wang, Lu Huang, Zheyi Wang, Ying Liu, Yanning Zheng   +6 more
wiley   +1 more source

Severe Methemoglobinemia Due to Accidental Ingestion of Nitrite-Containing Nail Polish Remover: A Case Report. [PDF]

Am J Case Rep
Gould LA, Carman M, Zahn MB, Amatea J.
europepmc   +1 more source

Prenatal Exome Sequencing Identifies Dual Maternal‐Fetal Diagnosis of HbF Mission Bay, a Novel HBG2 Variant Associated With Methemoglobinemia, Hypoxia and Hemolytic Anemia

Prenatal Diagnosis, EarlyView.
ABSTRACT Prenatal exome sequencing (ES) can establish rare genetic diagnoses in a fetus but may also lead to occult genetic diagnosis in a biological parent. We present a case of dual fetal and maternal diagnosis by prenatal ES, in a fetus with unexplained anemia and in a pregnant patient with sickle cell disease (SCD) and recurrent unexplained hypoxia.
Matthew A. Shear, Billie Lianoglou, Ugur Hodoglugil, W. Patrick Devine, Ashutosh Lal, Juan Gonzalez, Teresa N. Sparks   +6 more
wiley   +1 more source

Porphyromonas gingivalis produces a functional HemH ferrochelatase important for its survival in a heme-limited environment. [PDF]

Sci Rep
Śmiga M, Roszkiewicz E, Wojtal N, Olczak T.   +3 more
europepmc   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

The <i>Mycobacterium smegmatis bd</i>-II terminal oxidase employs a carboxylate shift mechanism. [PDF]

Proc Natl Acad Sci U S A
Kovalova T, Janczak M, Gamiz-Hernandez AP, Lundin D, Sharma S, Vilhjálmsdóttir J, Sjöstrand D, Kaila VRI, Högbom M, Ädelroth P.   +9 more
europepmc   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Bafilomycin A1 is a promising therapeutic agent against T. spiralis infection by inhibiting the heme-transporting ATP6V0C/HRG-1 complex. [PDF]

PLoS Pathog
He Y, Wang Y, He X, Lv Q, Vallee I, Boireau P, Ding J, Liu X.   +7 more
europepmc   +1 more source