Results 251 to 260 of about 414,309 (352)

Sequential Optimization of Multivariate Metal–Organic Framework Based Biocatalysis

Small, EarlyView.
A sequential Latin hypercube sampling–coupled Bayesian optimization (LHS‐BO) workflow integrates multivariate zirconium‐based metal–organic framework based biocomposite (E‐MOF) design with enzyme biocascade reaction optimization. The optimized E‐MOFs stabilize glucose oxidase and horseradish peroxidase in bioactive conformation, exhibiting high ...
Weibin Liang, Sisi Zheng, Ross Andrew Shalliker, Christian Doonan, Feng Li   +4 more
wiley   +1 more source

A Growth-Coupled Evolutionary Strategy Enhances Heme Biosynthesis in Saccharomyces cerevisiae. [PDF]

Biotechnol J
Bang S, Kim E, Park S, Kim P.
europepmc   +1 more source

Structural analysis of catalase from two Musa accessions, FHIA18 and Williams, and from Ravenala madagascariensis [PDF]

, 2008
Jaufeerally-Fakim, Y., Khroyratty, S.S.S., Souza, M.T.   +2 more
core   +1 more source

Activatable smart contrast agents for photoacoustic imaging

Smart Molecules, EarlyView.
This review highlights recent advances in smart activatable photoacoustic imaging (PAI) contrast agents, which dynamically modulate their optical properties in response to external stimuli or microenvironmental cues. It discusses their molecular design, activation mechanisms, biomedical applications, and future prospects for clinically tailored use ...
Donghyeon Oh, Jihye Lee, Suyoung Park, Juyoung Yoon, Won Jong Kim, Chulhong Kim   +5 more
wiley   +1 more source

Biallelic pathogenic hydroxymethylbilane synthase gene variants of a neurodegenerative disorder with progressive cystic leukoencephalopathy: a case report. [PDF]

J Med Case Rep
Schacht G, Elbracht M, Minder AE, Stauch T, Stoppe A, Lausberg E, Häusler M.   +6 more
europepmc   +1 more source

Reduced stress defense in heme oxygenase 1-deficient cells.

Proceedings of the National Academy of Sciences of the United States of America, 1997
Kenneth D. Poss, S. Tonegawa
semanticscholar   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Role of biliverdin reductase, a heme degradation pathway enzyme, in the development of vasospasm after subarachnoid hemorrhage. [PDF]

J Neurointerv Surg
Hasanpour-Segherlou Z, Hutchinson H, Xu H, Amini S, Klaas E, Martinez ME, Lucke-Wold B, Hosaka K, Hoh B.   +8 more
europepmc   +1 more source

Metallic Axial Asymmetry in Dome‐Like Iron Porphyrins Boosts Advanced Oxidation Processes: Implication of Allosteric Effect of Heme Peroxidases

Small Structures, EarlyView.
A structure–activity relationship between dome‐deformation‐induced metallic axial asymmetry and catalytic efficiency in iron porphyrins was established, providing a molecular blueprint for designing high‐performance enzyme‐mimetic catalysts. The remarkable catalytic activity of heme enzymes originates from distinctive allosteric effects mediated by ...
Junhao Gao, Qiuhua Liu, Yusheng Zhang, Zhihong Fang, Wenping Guo, Zhenfang Zhang, Lei Bao, Tianyi Ma, Zaichun Zhou   +8 more
wiley   +1 more source