Results 201 to 210 of about 44,892 (270)

Tricarboxylic Acid (TCA) Cycle Enzyme Alpha‐Ketoglutarate Dehydrogenase (KGDH) as a Nexus for the Regulation of Macrophage Polarization

Journal of Cellular Biochemistry, Volume 127, Issue 7, July 2026.
ABSTRACT Macrophage metabolism has been increasingly studied in recent years for its potential as a therapeutic target across multiple pathologies. In this article, we propose that the tricarboxylic acid (TCA) cycle enzyme alpha‐ketoglutarate (KG) dehydrogenase (KGDH) serves as a nexus for regulating macrophage polarization toward pro‐inflammatory (M1)
Meijing Li, Ryan J. Mailloux
wiley   +1 more source

Silencing the Signal: The Metastasis Suppressor NDRG1 Disrupts Small Extracellular Vesicle‐Mediated Crosstalk in Pancreatic Cancer

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
NDRG1 suppresses pancreatic cancer progression by disrupting small extracellular vesicle biogenesis, altering cargo composition, and inhibiting EV uptake by cancer cells—thereby impairing tumour–stroma communication and fibrotic activation. This study reveals NDRG1 as a novel regulator of extracellular vesicle dynamics and a promising therapeutic ...
Jiawei Chang, Shafi Alenizi, Heloisa Zaccaron Milioli, Winston Lay, Saranya Pounraj, Yujie Li, Mekonnen Sisay Shiferaw, Elham Hosseini‐Beheshti, Zaklina Kovacevic   +8 more
wiley   +1 more source

Metabolic Dysfunction‐Associated Fatty Liver Disease: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 7, July 2026.
Extracellular vesicles play a crucial role in interorgan crosstalk of adipose–liver and gut–liver axes and hold potential as therapeutic targets and drug delivery systems for metabolic dysfunction‐associated fatty liver disease (MAFLD). Abbreviations: AT: adipose tissue; EVs: extracellular vesicles; HL: healthy liver; NAFL: nonalcoholic fatty liver ...
Zhifu Cui, Xiaxia Du, Felix Kwame Amevor, Yaoyao Xia, You Yang, Lingbin Liu   +5 more
wiley   +1 more source

CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation. [PDF]

Biomolecules
Key J, Gispert S, Kandi AR, Heinz D, Hamann A, Osiewacz HD, Meierhofer D, Auburger G.   +7 more
europepmc   +1 more source

Fendioxypyracil, a new and systemic PPO‐inhibiting herbicide for X‐spectrum weed control

Pest Management Science, Volume 82, Issue 7, Page 6794-6807, July 2026.
This graphical abstract presents the discovery and synthesis of PPO herbicide structures with a central pyridine core, showing molecular conformations, dose–response inhibition curves for PPO1 and PPO2, and comparative weed and grass control efficacy of fendioxypyracil versus other herbicides in greenhouse and field trials.
Tobias Seiser, Aimone Porri, Philipp Johnen, Silke Zeyer, Judith Wahrheit, Michael Betz, Breght Vandenberghe, Scott Asher, Liliana Parra Rapado   +8 more
wiley   +1 more source

Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics. [PDF]

Front Cell Dev Biol, 2020
Gonzalez-Ibanez AM, Ruiz LM, Jensen E, Echeverria CA, Romero V, Stiles L, Shirihai OS, Elorza AA.   +7 more
europepmc   +1 more source

Multi‐Omics Profiling of the Scaphoideus titanus Yeast‐Like Symbiont Guides the Bioinformatic Discovery of Related Fungal Symbioses in Insects

Environmental Microbiology, Volume 28, Issue 7, July 2026.
Genomic, proteomic and phylogenetic analyses of the obligate yeast‐like symbiont (YLS) associated with Scaphoideus titanus revealed retained metabolic flexibility and a monophyletic origin of insect‐associated YLSs within a free‐living fungal lineage. A novel computational pipeline was used to mine NCBI transcriptomic data and identified new candidate ...
Simona Abbà, Marta Vallino, Alessandro Cicerone, Simona Cirrincione, Beatrice Aiuto, Luciana Galetto, Marika Rossi   +6 more
wiley   +1 more source

Circadian‐Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3–NO Pathway

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Hearing impairment is attributed to factors such as age, genetic predisposition, and environmental influences, among which environmental factors are considered modifiable. Among various environmental factors, the role of poor lifestyle habits is particularly critical, yet the specific mechanisms by which they contribute to hearing damage ...
Siyu Qiu, Shiyi Cai, Rong Xie, Chang Liu, Yingzi He   +4 more
wiley   +1 more source

Selective Autophagy Receptor CsNBR1 Confers Citrus Huanglongbing Resistance by Degrading ‘Candidatus Liberibacter Asiaticus’ Virulence Effectors

Molecular Plant Pathology, Volume 27, Issue 7, July 2026.
Overexpression of CsNBR1 confers HLB resistance in citrus by degrading CLas effector proteins, including SDE5115, SDE1, SDE19 and SDE5, via the autophagy pathway. ABSTRACT The selective autophagy receptor NEIGHBOUR OF BRCA1 (NBR1) is a key regulator of plant immunity, but its role against bacterial pathogens remains poorly understood.
Yaqian Shi, Xuejin Cui, Fang Fang, Zaiyu Yang, Yalin Mei, Shimian Ma, Changyong Zhou, Xuefeng Wang   +7 more
wiley   +1 more source