Results 181 to 190 of about 732,679 (273)

Substrate‐Dependent Crosslinking by the Cytochrome P450 From Aminopyruvatide Biosynthesis

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
Substitutions in the aminopyruvatide precursor peptide altered the C─C linkage formed from a YLY motif by the P450 ApyO to a N─C linkage in a WLY motif. Moreover, constitutional isomers crosslinked by C─C and C─O linkages were formed from YYY or YWY motifs. ABSTRACT Cytochrome P450s catalyze an array of reactions including crosslinking of aromatic side
Chandrashekhar Padhi, Dinh T. Nguyen, Lingyang Zhu, Lide Cha, Jesse W. Wald, Douglas A. Mitchell, Wilfred A. van der Donk   +6 more
wiley   +2 more sources

The role of iron in normal and impaired testicular function

Andrology, Volume 14, Issue 8, Page 2373-2387, November 2026.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

MdPHYB2‐MdPIF1 Module Regulates Transcription Factors to Mediate Light‐Dependent ALA‐Induced Apple Anthocyanin Biosynthesis

Plant, Cell &Environment, Volume 49, Issue 11, Page 7808-7824, November 2026.
ABSTRACT Light is a primary environmental signal that induces plant anthocyanin accumulation. The plant growth regulator 5‐aminolevulinic acid (ALA) has also been proven to effectively promote anthocyanin accumulation in apple. However, the underlying regulatory mechanisms remain unknown.
Liuzi Zhang, Yuyan An, Jianting Zhang, Liangju Wang   +3 more
wiley   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

Elucidating the Molecular Impact of DA29‐Induced ClpP Chemoactivation on Mitochondrial Function

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
A promising approach to tackling DIPG, a lethal pediatric brain tumor, relies on small molecules capable of activating the human mitochondrial protease hClpP. The novel piperazine‐based compound DA29 specifically activates endogenous hClpP, thereby compromising mtDNA levels, mitoribosomes, and OXPHOS complex subunits.
Francesca Rizzo, Morena Miciaccia, Maria Grazia Perrone, Antonio Scilimati, Paola Loguercio Polosa, Francesco Bruni   +5 more
wiley   +1 more source

Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley   +1 more source

Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product

Microbiology and Molecular Biology Reviews, 2017
H. Dailey, T. Dailey, S. Gerdes, D. Jahn, M. Jahn, M. O'Brian, M. Warren   +6 more
semanticscholar   +1 more source

PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis

Journal of Clinical Investigation, 2017
Moon-Suhn Ryu, De-Liang Zhang, O. Protchenko, Minoo Shakoury‐Elizeh, C. Philpott   +4 more
semanticscholar   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, Volume 600, Issue 20, Page 2981-3008, October 2026.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Phototherapy Strategies for Cancer Treatment: Mechanisms and Emerging Nanomaterials

Aggregate, Volume 7, Issue 10, October 2026.
Phototherapy offers spatiotemporally controlled cancer treatment by converting light into heat, reactive oxygen species, immune activation, and therapeutic gas release. This review summarizes the mechanisms and emerging nanomaterials for photothermal therapy, photodynamic therapy, photoimmunotherapy, and photo‐gas therapy, emphasizing structure ...
Fan Liu, Jun Huang
wiley   +1 more source