Results 211 to 220 of about 44,892 (270)

Decoding GUN1 in plastid‐to‐nucleus signaling: what it doesn't, what it does, and why it matters

New Phytologist, Volume 251, Issue 1, Page 81-88, July 2026.
Publication history of plant GUN1 research. Summary Plastid‐to‐nucleus retrograde signaling coordinates nuclear gene expression with the developmental and physiological state of plastids. GENOMES UNCOUPLED 1 (GUN1), a chloroplast‐localized PPR‐SMR protein, remains a central yet poorly understood component of this network.
Marco Wendler, Dario Leister, Tatjana Kleine   +2 more
wiley   +1 more source

5-Aminolevulinate synthase catalysis: The catcher in heme biosynthesis. [PDF]

Mol Genet Metab, 2019
Stojanovski BM, Hunter GA, Na I, Uversky VN, Jiang RHY, Ferreira GC.   +5 more
europepmc   +1 more source

Metabolic Reprogramming of a Phenolic Acid by a Plant P450 Monooxygenase Reverses Bacterial Immunosuppression

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4672-4688, July 2026.
Ralstonia solanacearum suppresses P450 activity to block VA‐to‐VanA conversion, leading to VA accumulation and compromised immunity. ABSTRACT Soil acidification often exacerbates plant diseases caused by soil‐borne pathogens like Ralstonia solanacearum, but the underlying molecular mechanisms remain elusive. This study unveils a sophisticated metabolic
Hua Wang, Xiaoshuang Peng, Xinrui Wang, Ruiyu Yang, Tao Liu, Huidi Liu, Chao Zhao, Hong Zhou, Liang Yang, Shili Li, Wei Ding   +10 more
wiley   +1 more source

Tolerance to Phosphorus Deficiency Improves Seed Phytic Acid‐to‐Iron Molar Ratios in Common Bean

Plant, Cell &Environment, Volume 49, Issue 7, Page 4152-4165, July 2026.
ABSTRACT Although significant advances have been achieved in the biofortification of common beans to overcome deficiencies in Zinc (Zn) and iron (Fe), the mechanisms involved remain poorly understood. We thus explored the relationships between phosphorus nutrition and Zn and Fe accumulation in four bean genotypes (Edar, Nizok, Colorado and Chimbolos ...
Barbara Karpinska, Christine H. Foyer
wiley   +1 more source

Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A

Angewandte Chemie, Volume 138, Issue 26, 22 June 2026.
Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham, Edward S. Hems, Daniel C. L. Van, Justin E. Clarke, Sergey Nepogodiev, Julius S. P. Adamson, Christian Bassi, Michael E. Webb, Glyn R. Hemsworth, Orde Q. Munro, Barrie Wilkinson, Ryan F. Seipke   +11 more
wiley   +2 more sources

Cytochrome P450 1a (CYP1A)‐Knockout Javanese Medaka Fish Exhibit Diabetic Traits and Reduced Reproductive Capacity

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Analyses of cytochrome P450 1a (CYP1A)‐knockout (KO) Javanese medaka (Oryzias javanicus) revealed that CYP1A is involved in glucose regulation and reproduction. In the KO fish, significant increases in hepatic transcripts of insulin, glucagon, and somatostatin genes, as well as elevated blood glucose, liver mass, and liver triglyceride levels ...
Suhaila Rusni, Yuki Yoshioka, Hilda Mardiana Pratiwi, Toshiyuki Takagi, Muhammad Rahmad Royan, Yuya Hojo, Seiichi Uno, Shinji Kanda, Yusuke Takehana, Masato Kinoshita, Koji Inoue   +10 more
wiley   +1 more source

Crystal Structure and Conformational Dynamics of N─N Bond‐Forming Piperazate Synthase

ChemBioChem, Volume 27, Issue 12, 26 June 2026.
Piperazate synthases (PZSs) catalyze the key N─N bond formation in the biosynthesis of the rare amino acid piperazic acid. X‐ray crystal structures of apo‐ and holo‐SbPZS show a dimeric enzyme with two heme‐containing active sites, where histidine residues coordinate the iron centers.
Nikita Pal, Simon Schröder, Amit Singh Sahrawat, Christian C. Gruber, Martin A. Hayes, Bastian Daniel, Sandy Schmidt, Karl Gruber   +7 more
wiley   +1 more source

Co(II), Cu(II), and Ni(II) Coordination Complexes: Synthesis, Characterization, Experimental, and Computational Study on Potential Antiplasmodial Activity

ChemMedChem, Volume 21, Issue 12, 26 June 2026.
Four isostructural complexes (C1–C4) derived from 2‐(tert‐butoxy)‐6‐(1H‐imidazol‐1‐yl)pyridine with axial halides exhibit octahedral trans M(L)4X2 geometries, confirmed by X‐ray diffraction. They feature a discrete 1,6M7−1 topology, identified using ToposPro analysis.
David Ezenarro‐Salcedo, Daniela Fonseca‐López, Alexander Patiño‐Cubides, María C. Velasco‐Pareja, María F. Yasnot‐Acosta, Camilo Serrano‐Sterling, Ana Rodríguez, Mario A. Macías, Adrian L. Orjuela, Augusto Valderrama‐Aguirre, John J. Hurtado   +10 more
wiley   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources