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JBIC Journal of Biological Inorganic Chemistry, 1997
Heme is a necessary component in a variety of oxygen-binding proteins and electron-transfer proteins, and as such it occupies a central role in cellular and organismal metabolism. With only rare exceptions, organisms that utilize heme possess the entire biosynthetic pathway to produce this tetrapyrrole compound.
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Heme is a necessary component in a variety of oxygen-binding proteins and electron-transfer proteins, and as such it occupies a central role in cellular and organismal metabolism. With only rare exceptions, organisms that utilize heme possess the entire biosynthetic pathway to produce this tetrapyrrole compound.
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The effects of chemicals on hepatic heme biosynthesis
Trends in Pharmacological Sciences, 1978The administration of Sedormid (2-isopropylpent-4-enoylurea) to rabbits resulted in an experimental porphyria (Schmid and Schwartz, 1952) and the liver which was shown to be the major site of the metabolic disturbance contained large amounts of uro-, copro-, and proto-porphyrin. Sedormid (Fig.
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The Biosynthesis and Degradation of Heme
1978Research on the biosynthesis and degradation of heme and hemoproteins was and still is stimulated by the need to understand the nature of the many diseases where these orderly processes are disturbed. In the anemias, the body is unable to synthesize enough hemoglobin either because it cannot make erythrocytes fast enough, or because heme or globin ...
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Disturbances in the biosynthesis of heme in lead intoxication
The Journal of Pediatrics, 1964O N E of the cardinal manifestations of lead intoxication ia man is disturbance in the synthesis of heme. Indeed, this biosynthetic pathway is so sensitive to the toxic effects of lead, that two of the metaboli tes--delta aminolevulinate and coproporphyr in--can be consistently demonstrated in great excess in the urine even in the absence of clinical ...
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The regulation of heme biosynthesis.
Annals of clinical research, 1977Changes in the levels of the heme biosynthetic enzymes were studied in cells and protoplasts of Saccharomyces cerevisiae during glucose derepression and respiratory adaptation. On aerobic or anaerobic glucose derepression or in the presence of 3', 5' cyclic AMP the levels of beta-aminolevulinic acid dehydratase, protoporphyrinogen oxidase and ...
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Genome-Based Analysis of Heme Biosynthesis and Uptake in Prokaryotic Systems
Journal of Proteome Research, 2008Antonio Rosato, Gabriele Cavallaro
exaly