Results 141 to 150 of about 73,522 (298)

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

Heme oxygenase, steering dioxygen activation toward heme hydroxylation

, 2005
The activation of dioxygen by heme oxygenase proceeds via formation of an obligatory ferric hydroperoxide intermediate (FeIII-OOH), as is the case in the activation of dioxygen by monooxygenase enzymes. This review summarizes current understanding of the
Zeng, Yuhong, Rivera, Mario
core   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Resveratrol Inhibits Human Lung Adenocarcinoma Cell Metastasis by Suppressing Heme Oxygenase 1-Mediated Nuclear Factor-Kappa B Pathway and Subsequently Downregulating Expression of Matrix Metalloproteinases

, 2012
Resveratrol exhibits potential anti-carcinogenic activities. Heme oxygenase-1 (HO-1) is involved in angiogenesis and tumor metastasis. Matrix metalloproteinases (MMPs) are key enzymes in the degradation of extracellular matrix, and their expression may ...
劉博侖;蔡忠榮;黃吉志;周世華;兵岳忻;林豐彥;陳玉怜;陳汶吉;陳永祥;鍾飲文, LIU, PO-LEN;TSAI, JONG-RUNG;HWANG, JHI-JHU;CHOU, SHAH-HWA;PING, YUEH-HSIN;LIN, FENG-YEN;CHEN, YUH-LIEN;CHEN, WEN-CHI;CHEN, YUNG-HSIANG;CHONG, INN-WEN   +1 more
core  

Protective effects of extracellular vesicle‐like nanoparticles derived from Cannabis sativa adventitious roots against UVB‐induced damage in human keratinocytes

International Journal of Cosmetic Science, EarlyView.
Cannabis sativa root‐derived extracellular vesicle‐like nanoparticles (CA‐NPs) were isolated from adventitious root cultures and subjected to physicochemical characterization. Upon UVB exposure, keratinocytes exhibited increased ROS generation, apoptosis and MAPK activation, leading to oxidative stress and skin damage.
Dong Ho Bak, Su Hyun Park, Young Bae Ryu, Cha Young Kim, Jae Cheol Jeong, Woo Sik Kim   +5 more
wiley   +1 more source

Gene Editing of Nicotiana benthamiana Architecture for Space‐Efficient Production of Recombinant Proteins in Closed Environments

Plant Biotechnology Journal, EarlyView.
ABSTRACT Indoor vertical farming (VF) offers practical advantages for the cultivation of plant protein bio‐factories including plant uniformity, product consistency, water/nutrient recycling and production cycles on a year‐round basis. Much progress has been achieved toward the development of innovative systems for artificial lighting, automated ...
Béatrice Giroux, Kristina LeBreux, Louis Feyzeau, Marie‐Claire Goulet, Charles Goulet, Dominique Michaud   +5 more
wiley   +1 more source

Vestigial Plastids in Parasitic Plants: Evolutionary Remnants or Adaptive Innovations?

Plant, Cell &Environment, EarlyView.
ABSTRACT Throughout the evolutionary history of plants, chloroplasts originating from a cyanobacterial endosymbiosis have undergone remarkable adaptation and specialization, giving rise to a multitude of plastid types. The evolution toward parasitism in plants represents a particularly extreme case of such specialization.
Laia Jené, Sergi Munné‐Bosch
wiley   +1 more source

Heme Oxygenase–1: A Cellular Hercules [PDF]

Hepatology, 2003
Brian S, Zuckerbraun, Timothy R, Billiar
openaire   +2 more sources

Heme Oxygenase-1 and breast cancer resistance protein protect against heme-induced toxicity

, 2013
Heme is the functional group of diverse hemoproteins and crucial for many cellular processes. However, heme is increasingly recognized as a culprit for a wide variety of pathologies, including sepsis, malaria, and kidney failure.
Wagener, Frank A D T G, Masereeuw, R., Dankers, Anita C A, Pennings, Sebastiaan W C, Russel, Frans G M, van Summeren, Frank, Pharmacology, Koenderink, Jan B, Sub General Pharmacology, Scharstuhl, Alwin, van den Heuvel, Jeroen J M W   +10 more
core   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source