Results 1 to 10 of about 55,902 (116)

Heme oxygenase-1 and malaria pathogenesis [PDF]

Frontiers in Immunology
Malaria is a life-threatening parasitic disease and remains a major cause of morbidity and mortality worldwide. The clinical course of malaria ranges from uncomplicated infection to severe disease, driven by extensive hemolysis, inflammation, and ...
Theophilus Wakai, Theophilus Wakai, Shalom Chinedu, Shalom Chinedu, Israel Afolabi   +4 more
doaj   +2 more sources

Desaturation and heme elevation during COVID-19 infection: A potential prognostic factor of heme oxygenase-1

Journal of Microbiology, Immunology and Infection, 2021
Increased heme levels, anemia, and desaturation occur during infection. We aimed to compare the levels of heme, heme oxygenase-1 (HO-1), ferritin, and bilirubin in coronavirus disease 2019 (COVID-19) patients at different saturation levels. Heme and HO-1
Wen-Lin Su, Ching-Feng Cheng, Chih-Pei Lin   +2 more
exaly   +3 more sources

Heme catabolism and heme oxygenase-1-expressing myeloid cells in pathophysiology [PDF]

Frontiers in Immunology
Although the pathological significance of myeloid cell heterogeneity is still poorly understood, new evidence indicates that distinct macrophage subsets are characterized by specific metabolic programs that influence disease onset and progression. Within
Francesca Maria Consonni, Francesca Maria Consonni, Martina Incerti, Martina Incerti, Milena Bertolotti, Giulia Ballerini, Giulia Ballerini, Valentina Garlatti, Valentina Garlatti, Antonio Sica, Antonio Sica   +10 more
doaj   +2 more sources

Heme oxygenase-1: potential therapeutic targets for periodontitis [PDF]

PeerJ
Periodontitis is one of the most prevalent inflammatory disease worldwide, which affects 11% of the global population and is a major cause of tooth loss.
Weiwei Lv, Shichen Hu, Fei Yang, Dong Lin, Haodong Zou, Wanyan Zhang, Qin Yang, Lihua Li, Xiaowen Chen, Yan Wu   +9 more
doaj   +3 more sources

Alternative 5' untranslated regions are involved in expression regulation of human heme oxygenase-1. [PDF]

PLoS ONE, 2013
The single nucleotide polymorphism rs2071746 and a (GT)n microsatellite within the human gene encoding heme oxygenase-1 (HMOX1) are associated with incidence or outcome in a variety of diseases.
Marcel Kramer, Christoph Sponholz, Monique Slaba, Bianka Wissuwa, Ralf A Claus, Uwe Menzel, Klaus Huse, Matthias Platzer, Michael Bauer   +8 more
doaj   +1 more source

Heme, Heme Oxygenase-1, Statins, and SARS-CoV-2

Antioxidants, 2023
Heme, a metalloporphyrin, or more specifically, a tetrapyrrole containing ferrous iron, is an ancient molecule [...]
David K. Stevenson, Hendrik J. Vreman, Ronald J. Wong   +2 more
doaj   +1 more source

Endoplasmic reticulum anchored heme-oxygenase 1 faces the cytosol

Haematologica, 2012
Heme-oxygenase 1 is an endoplasmic reticulum-anchored enzyme that breaks down heme into iron, carbon monoxide and biliverdin. Heme is a hydrophobic co-factor in many proteins, including hemoglobin.
Yehonatan Gottlieb, Marianna Truman, Lyora A. Cohen, Yael Leichtmann-Bardoogo, Esther G. Meyron-Holtz   +4 more
doaj   +1 more source

Subarachnoid Hemorrhage Increases Level of Heme Oxygenase-1 and Biliverdin Reductase in the Choroid Plexus

Frontiers in Cellular Neuroscience, 2020
Subarachnoid hemorrhage is a specific, life-threatening form of hemorrhagic stroke linked to high morbidity and mortality. It has been found that the choroid plexus of the brain ventricles forming the blood-cerebrospinal fluid barrier plays an important ...
Peter Solár, Peter Solár, Peter Solár, Václav Brázda, Václav Brázda, Shahaf Levin, Alemeh Zamani, Radim Jančálek, Radim Jančálek, Petr Dubový, Marek Joukal   +10 more
doaj   +1 more source

Pharmacological Significance of Heme Oxygenase 1 in Prostate Cancer

Current Issues in Molecular Biology, 2023
Heme oxygenase 1 (HO-1) is a detoxifying antioxidant microsomal enzyme that regulates inflammation, apoptosis, cell proliferation, and angiogenesis in prostate cancer (PCa).
Mohamed Ben-Eltriki, Erysa J. Gayle, Noah Walker, Subrata Deb   +3 more
doaj   +1 more source

How Heme Oxygenase-1 Prevents Heme-Induced Cell Death. [PDF]

PLoS ONE, 2015
Earlier observations indicate that free heme is selectively toxic to cells lacking heme oxygenase-1 (HO-1) but how this enzyme prevents heme toxicity remains unexplained.
Lilibeth Lanceta, Jacob M Mattingly, Chi Li, John W Eaton   +3 more
doaj   +1 more source