Results 11 to 20 of about 137,188 (203)
Roles of Heme Oxygenase-1 in Neuroinflammation and Brain Disorders
Antioxidants, 2022 The heme oxygenase (HO) system is believed to be a crucial mechanism for the nervous system under stress conditions. HO degrades heme to carbon monoxide, iron, and biliverdin.
Yi‐Hsuan Wu, H. Hsieh
semanticscholar +1 more source
Blood, 2021 Sickle cell disease (SCD) is characterized by increased hemolysis which results in plasma heme overload and ultimately cardiovascular complications. Here, we hypothesized that increased heme in SCD causes upregulation of heme oxygenase 1 (Hmox1) which ...
Archita V. Menon +6 more
semanticscholar +1 more source
The Diverse Roles of Heme Oxygenase-1 in Tumor Progression
Frontiers in Immunology, 2021 Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in response to a variety of stimuli to degrade heme, which generates the biologically active catabolites carbon monoxide (CO), biliverdin and ferrous iron (Fe2+).
K. N. Luu Hoang +2 more
semanticscholar +1 more source
A Dual Role of Heme Oxygenase-1 in Tuberculosis
Frontiers in Immunology, 2022 Iron metabolism is vital for the survival of both humans and microorganisms. Heme oxygenase-1 (HO-1) is an essential stress-response enzyme highly expressed in the lungs, and catabolizes heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV ...
Sen Yang +4 more
semanticscholar +1 more source
Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress
Antioxidants, 2021 Atherosclerosis remains the underlying process responsible for cardiovascular diseases and the high mortality rates associated. This chronic inflammatory disease progresses with the formation of occlusive atherosclerotic plaques over the inner walls of ...
Jose Angel Alonso-Piñeiro +4 more
semanticscholar +1 more source
Heme Oxygenase 1: A Defensive Mediator in Kidney Diseases
International Journal of Molecular Sciences, 2021 The incidence of kidney disease is rising, constituting a significant burden on the healthcare system and making identification of new therapeutic targets increasingly urgent.
Anne Grunenwald +2 more
semanticscholar +1 more source
Heme Oxygenase-1 Expression Affects Murine Abdominal Aortic Aneurysm Progression. [PDF]
, 2016 Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is a cytoprotective enzyme upregulated in the vasculature by increased flow and inflammatory stimuli.
Azuma, Junya +13 more
core +8 more sources
Heme, Heme Oxygenase-1, Statins, and SARS-CoV-2
Antioxidants, 2023 Heme, a metalloporphyrin, or more specifically, a tetrapyrrole containing ferrous iron, is an ancient molecule [...]
David K. Stevenson +2 more
doaj +1 more source
Alternative 5' untranslated regions are involved in expression regulation of human heme oxygenase-1. [PDF]
PLoS ONE, 2013 The single nucleotide polymorphism rs2071746 and a (GT)n microsatellite within the human gene encoding heme oxygenase-1 (HMOX1) are associated with incidence or outcome in a variety of diseases.
Marcel Kramer +8 more
doaj +1 more source
Heme oxygenase 1 is differentially involved in blood flow-dependent arterial remodeling: role of inflammation, oxidative stress, and nitric oxide [PDF]
, 2011 Heme oxygenase 1 is induced by hemodynamic forces in vascular smooth muscle and endothelial cells. We investigated the involvement of heme oxygenase 1 in flow (shear stress)-dependent remodeling.
A. Caillon +7 more
core +3 more sources