Heme Oxygenase-1 as a Modulator of Intestinal Inflammation Development and Progression [PDF]
Frontiers in Immunology, 2018 Heme Oxygenase 1 (HMOX1) is an enzyme that catalyzes the reaction that degrades the heme group contained in several important proteins, such as hemoglobin, myoglobin, and cytochrome p450.
Valentina P. Sebastián +9 more
semanticscholar +4 more sources
Heme Oxygenase-1 Expression Affects Murine Abdominal Aortic Aneurysm Progression. [PDF]
, 2016 Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is a cytoprotective enzyme upregulated in the vasculature by increased flow and inflammatory stimuli.
Azuma, Junya +13 more
core +11 more sources
Frontiers in Immunology, 2020 Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors.
S. C. Funes +7 more
semanticscholar +1 more source
Heme oxygenase-1 orchestrates the immunosuppressive program of tumor-associated macrophages.
JCI Insight, 2020 Tumor-Associated Macrophages (TAMs) contribute to the maintenance of a strong immunosuppressive environment, supporting tumor progression and resistance to treatment.
Emmanuelle Alaluf +10 more
semanticscholar +1 more source
Heme oxygenase 1 is differentially involved in blood flow-dependent arterial remodeling: role of inflammation, oxidative stress, and nitric oxide [PDF]
, 2011 Heme oxygenase 1 is induced by hemodynamic forces in vascular smooth muscle and endothelial cells. We investigated the involvement of heme oxygenase 1 in flow (shear stress)-dependent remodeling.
A. Caillon +7 more
core +3 more sources
The induction of heme oxygenase 1 decreases contractility in human internal thoracic artery and radial artery grafts [PDF]
, 2005 ObjectiveSpasm remains a potential problem encountered during the use of arterial grafts in coronary artery bypass surgery. Heme oxygenase plays a role in the control of arterial vasoreactivity.
Achouh, Paul +8 more
core +1 more source
Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1. [PDF]
, 2015 Sickle cell disease is a risk factor for invasive bacterial infections, and splenic dysfunction is believed to be the main underlying cause. We have previously shown that the liberation of heme in acute hemolysis can induce heme oxygenase-1 during ...
Chakravorty, Subarna +6 more
core +4 more sources
Cellular Iron Depletion Weakens Induction of Heme Oxygenase-1 by Cadmium [PDF]
, 2011 Heme oxygenase-1 is an inducible cytoprotective gene, although its induction by environmental factors is not completely understood. This study aimed to ascertain if specific nutritive factors or related compounds influence heme oxygenase-1 expression. In
Lai, Chengzhi +2 more
core +1 more source
Heme Oxygenase-1 in Gastrointestinal Tract Health and Disease
Antioxidants, 2020 Heme oxygenase 1 (HO-1) is the rate-limiting enzyme of heme oxidative degradation, generating carbon monoxide (CO), free iron, and biliverdin. HO-1, a stress inducible enzyme, is considered as an anti-oxidative and cytoprotective agent.
Jose D. Puentes-Pardo +3 more
semanticscholar +1 more source
Heme oxygenase-1 deficiency alters erythroblastic Island formation, steady-state erythropoiesis and red blood cell lifespan in mice [PDF]
, 2015 Heme oxygenase-1 is critical for iron recycling during red blood cell turnover, whereas its impact on steady-state erythropoiesis and red blood cell lifespan is not known.
Andrade, Osvaldo Cooley +13 more
core +2 more sources