Results 11 to 20 of about 137,322 (324)

Metformin alleviates spinal cord injury by inhibiting nerve cell ferroptosis through upregulation of heme oxygenase-1 expression

open access: yesNeural Regeneration Research, 2023
[INLINE:1] Previous studies have reported upregulation of heme oxygenase-1 in different central nervous system injury models. Heme oxygenase-1 plays a critical anti-inflammatory role and is essential for regulating cellular redox homeostasis.
Zhihua Wang   +4 more
doaj   +2 more sources

Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1 [PDF]

open access: yesHaematologica, 2015
Sickle cell disease is a risk factor for invasive bacterial infections, and splenic dysfunction is believed to be the main underlying cause. We have previously shown that the liberation of heme in acute hemolysis can induce heme oxygenase-1 during ...
Ceri Evans   +6 more
doaj   +6 more sources

Clinical Significance of Heme Oxygenase 1 in Tumor Progression

open access: yesAntioxidants, 2021
Heme oxygenase 1 (HO-1) plays a key role in cell adaptation to stressors through the antioxidant, antiapoptotic, and anti-inflammatory properties of its metabolic products.
Mariapaola Nitti   +3 more
doaj   +2 more sources

Heme Oxygenase-1 as a Modulator of Intestinal Inflammation Development and Progression [PDF]

open access: yesFrontiers in Immunology, 2018
Heme Oxygenase 1 (HMOX1) is an enzyme that catalyzes the reaction that degrades the heme group contained in several important proteins, such as hemoglobin, myoglobin, and cytochrome p450.
Valentina P. Sebastián   +9 more
semanticscholar   +4 more sources

Heme oxygenase-1 in osteosarcoma

open access: yesJournal of Cancer Research and Therapeutics, 2020
Aim of Study: The present study was planned to analyze serum heme oxygenase-1 levels in osteosarcoma patients. Materials and Methods: Twenty five histopathologically confirmed cases of osteosarcoma localized without metastasis of all the ages attending ...
S. Kharb, M. Halder, Z. Kundu
semanticscholar   +3 more sources

How Heme Oxygenase-1 Prevents Heme-Induced Cell Death. [PDF]

open access: yesPLoS ONE, 2015
Earlier observations indicate that free heme is selectively toxic to cells lacking heme oxygenase-1 (HO-1) but how this enzyme prevents heme toxicity remains unexplained.
Lilibeth Lanceta   +3 more
doaj   +4 more sources

Targeting the Nrf2-Heme Oxygenase-1 Axis after Intracerebral Hemorrhage. [PDF]

open access: yesCurrent pharmaceutical design, 2017
BACKGROUND: Injury to cells adjacent to an intracerebral hemorrhage (ICH) is likely mediated at least in part by toxins released from the hematoma that initiate complex and interacting injury cascades.
J. Chen‐Roetling, R. Regan
semanticscholar   +3 more sources

Heme oxygenase-1 deletion affects stress erythropoiesis. [PDF]

open access: yesPLoS ONE, 2011
BACKGROUND:Homeostatic erythropoiesis leads to the formation of mature red blood cells under non-stress conditions, and the production of new erythrocytes occurs as the need arises.
Yu-An Cao   +5 more
doaj   +4 more sources

Immune-Related Functions of Heme Oxygenase-1

open access: yesAntioxidants, 2023
Heme oxygenase (HO)-1 is a well-known cytoprotective enzyme due to its enzymatic action, which involves the catalysis of heme into anti-apoptotic and antioxidant molecules such as bilirubin, biliverdin and CO [...]
Elias A. Lianos, Maria G. Detsika
doaj   +4 more sources

Heme catabolism and heme oxygenase-1-expressing myeloid cells in pathophysiology [PDF]

open access: yesFrontiers in Immunology
Although the pathological significance of myeloid cell heterogeneity is still poorly understood, new evidence indicates that distinct macrophage subsets are characterized by specific metabolic programs that influence disease onset and progression. Within
Francesca Maria Consonni   +10 more
doaj   +2 more sources

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