Results 41 to 50 of about 100,369 (340)

Human AKI and Heme Oxygenase-1 [PDF]

Journal of the American Society of Nephrology, 2012
Findings derived from animal models of AKI gain clinical credence and appeal when translational studies corroborate their occurrence in human AKI. In the current issue of JASN , Zager et al.
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Heme Oxygenase-1 [PDF]

Circulation, 2006
Schmid and coworkers1 were the first to report on the presence of heme oxygenase (HO) in liver microsomes capable of degrading heme to bilirubin, and this activity was subsequently dissociated from cytochrome P-450.2,3 HO catalyzes the first and rate-limiting step in the oxidative degradation of heme (Fe-protoporphyrin-IX) to carbon monoxide (CO ...
Roland, Stocker, Mark A, Perrella
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Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors

Data in Brief, 2017
The data have been obtained from the Heme Oxygenase Database (HemeOxDB) and refined according to the 2D-QSAR requirements. These data provide information about a set of more than 380 Heme Oxygenase-1 (HO-1) inhibitors.
Emanuele Amata, Agostino Marrazzo, Maria Dichiara, Maria N. Modica, Loredana Salerno, Orazio Prezzavento, Giovanni Nastasi, Antonio Rescifina, Giuseppe Romeo, Valeria Pittalà   +9 more
doaj   +1 more source

Metformin alleviates spinal cord injury by inhibiting nerve cell ferroptosis through upregulation of heme oxygenase-1 expression

Neural Regeneration Research
[INLINE:1] Previous studies have reported upregulation of heme oxygenase-1 in different central nervous system injury models. Heme oxygenase-1 plays a critical anti-inflammatory role and is essential for regulating cellular redox homeostasis.
Zhihua Wang, Wu Zhou, Zhixiong Zhang, Lulu Zhang, Meihua Li   +4 more
doaj   +1 more source

Development of inhibitory antibodies to therapeutic factor VIII in severe hemophilia A is associated with microsatellite polymorphisms in the HMOX1 promoter

Haematologica, 2013
Induction of heme oxygenase-1, a stress-inducible enzyme with anti-inflammatory activity, reduces the immunogenicity of therapeutic factor VIII in experimental hemophilia A.
Yohann Repessé, Ivan Peyron, Jordan D Dimitrov, Suryasarathi Dasgupta, Elika Farrokhi Moshai, Catherine Costa, Annie Borel-Derlon, Benoit Guillet, Roseline D’Oiron, Achille Aouba, Chantal Rothschild, Johannes Oldenburg, Anna Pavlova, Srinivas V Kaveri, Sébastien Lacroix-Desmazes   +14 more
doaj   +1 more source

The silent information regulator 1 pathway attenuates ROS-induced oxidative stress in Alzheimer's disease [PDF]

Journal of Integrative Neuroscience, 2020
We show that down-regulation of circular ribonucleic acid 0001588 with small interfering-circular ribonucleic acid 0001588 mimics promoted caspase-3 and caspase-9 activity levels, increased lactate dehydrogenase activity levels, and reduced cell growth ...
Rongyan Zhu, Xiuyan Qi, Cuiping Liu, Dongxin Wang, Li Li, Xiaofeng Liu, Yongge Hou, Xiaohui Su, Huiqian Lin
doaj   +1 more source

Effects of heme oxygenase isozymes on Leydig cells steroidogenesis [PDF]

, 2009
In the present study, we demonstrate the expression of heme oxygenase (HO) isozymes, HO-1 and HO-2 (listed as HMOX1 and HMOX2 in the MGI Database), in MA-10 Leydig tumor cells and its effect on steroidogenesis. The well-known HO inducer, hemin, increased
Besio Moreno, Marcos Alberto, Cymeryng, Cora Betriz, Monzón, Casandra Margarita, Pagotto, Romina María del Luján, Pignataro, Omar Pedro, Piotrkowski, Barbara, Reche, Cecilia   +6 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Strontium Ranelate Elevates Expression of Heme Oxygenase-1 and Decreases Alveolar Bone Loss in Rats

eJournal of Oral Maxillofacial Research, 2018
Objectives: The purpose of this study was to determine the effects of strontium ranelate on ligature-induced periodontitis in rats and assess the putative involvement of heme oxygenase-1 (HO-1) pathway in these effects.
Ricardo Basto Souza, Francisco Isaac Fernandes Gomes, Karuza Maria Alves Pereira, Paula Goes Pinheiro Dutra, Rodrigo Maranguape Silva da Cunha, Hellíada Vasconcelos Chaves, Mirna Marques Bezerra   +6 more
doaj   +1 more source

Heme Oxygenase-1 Deficiency [PDF]

Indian Pediatrics, 2021
Renji, Soumya, Shah, Nitin, Madkaikar, Manisha   +2 more
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