Results 41 to 50 of about 137,322 (324)

Heme Oxygenase-1: A Metabolic Nike [PDF]

Antioxidants & Redox Signaling, 2014
Heme degradation, which was described more than 30 years ago, is still very actively explored with many novel discoveries on its role in various disease models every year.The heme oxygenases (HO) are metabolic enzymes that utilize NADPH and oxygen to break apart the heme moiety liberating biliverdin (BV), carbon monoxide (CO), and iron.
Wegiel, Barbara, Nemeth, Zsuzsanna, Correa-Costa, Matheus, Bulmer, Andrew C, Otterbein, Leo E   +4 more
openaire   +3 more sources

Transient receptor potential melastatin 2–mediated heme oxygenase-1 has a role for bacterial clearance by regulating autophagy in peritoneal macrophages during polymicrobial sepsis

Innate Immunity, 2019
Our previous study indicated an important protective role of transient receptor potential melastatin 2 (TRPM2) in controlling bacterial clearance in macrophages during polymicrobial sepsis by regulating heme oxygenase-1.
XiaoWei Qian, Hao Cheng, XinZhong Chen
doaj   +1 more source

Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2

BMC Complementary and Alternative Medicine, 2011
Background Both resveratrol and vitamin C (ascorbic acid) are frequently used in complementary and alternative medicine. However, little is known about the underlying mechanisms for potential health benefits of resveratrol and its interactions with ...
Hori Osamu, Hashida Koji, Döring Frank, Schmelzer Constance, Schrader Charlotte, Breckwoldt Dorothea, Boesch-Saadatmandi Christine, Wagner Anika E, Matsugo Seiichi, Rimbach Gerald   +9 more
doaj   +1 more source

Identification of a Novel Self-Sufficient Styrene Monooxygenase from Rhodococcus opacus 1CP. [PDF]

, 2009
Sequence analysis of a 9-kb genomic fragment of the actinobacterium Rhodococcus opacus 1CP led to identification of an open reading frame encoding a novel fusion protein, StyA2B, with a putative function in styrene metabolism via styrene oxide and ...
Berkel, W.J.H., van, Eulberg, D., Kaschabek, S.R., Lakner, S., Schloemann, M., Tischler, D.   +5 more
core   +4 more sources

A comparison of melatonin and α-lipoic acid in the induction of antioxidant defences in L6 rat skeletal muscle cells. [PDF]

, 2015
Aging is characterized by a progressive deterioration in physiological functions and metabolic processes. The loss of cells during aging in vital tissues and organs is related to several factors including oxidative stress and inflammation.
Borsani, Elisa, Cocchi, Marco Angelo, Favero, Gaia, Giugno, Lorena, Nardo, Lorenzo, Reiter, Russel J, Rezzani, Rita, Rodella, Luigi Fabrizio   +7 more
core   +1 more source

Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells. [PDF]

PLoS ONE, 2011
In mammalian cells, heme can be degraded by heme-oxygenases (HO). Heme-oxygenase 1 (HO-1) is known to be the heme inducible isoform, whereas heme-oxygenase 2 (HO-2) is the constitutive enzyme.
Liliane R Alves, Elaine S Costa, Marcos H F Sorgine, Maria Clara L Nascimento-Silva, Cristina Teodosio, Paloma Bárcena, Hugo C Castro-Faria-Neto, Patrícia T Bozza, Alberto Orfao, Pedro L Oliveira, Clarissa M Maya-Monteiro   +10 more
doaj   +1 more source

Nitric Oxide Mediates Biofilm Formation and Symbiosis in Silicibacter sp. Strain TrichCH4B. [PDF]

, 2015
UnlabelledNitric oxide (NO) plays an important signaling role in all domains of life. Many bacteria contain a heme-nitric oxide/oxygen binding (H-NOX) protein that selectively binds NO.
Marletta, Michael A, Rao, Minxi, Smith, Brian C   +2 more
core   +3 more sources

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Regulation of Complement Activation by Heme Oxygenase-1 (HO-1) in Kidney Injury

Antioxidants, 2021
Heme oxygenase is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves the degradation of heme to biliverdin with simultaneous release of ...
Maria G. Detsika, Elias A. Lianos
doaj   +1 more source

Heme Oxygenase-1 in Central Nervous System Malignancies

Journal of Clinical Medicine, 2020
Central nervous system tumors are the most common pediatric solid tumors and account for 20–25% of all childhood malignancies. Several lines of evidence suggest that brain tumors show altered redox homeostasis that triggers the activation of various ...
G. Sferrazzo, M. Di Rosa, E. Barone, G. Li Volti, N. Musso, D. Tibullo, I. Barbagallo   +6 more
semanticscholar   +1 more source