Results 101 to 110 of about 188,137 (274)

Anti-Inflammatory activity of a polyphenolic extract from Arabidopsis thaliana in in vitro and in vivo models of Alzheimer's Disease [PDF]

, 2019
Alzheimer's disease (AD) is the most common neurodegenerative disorder and the primary form of dementia in the elderly. One of the main features of AD is the increase in amyloid-beta (Aβ) peptide production and aggregation, leading to oxidative stress ...
Casale, Assunta Maria, Costantino, Paolo, D'Erme, Maria, Francioso, Antonio, Gazzino, Roberta, Mancini, Patrizia, Mattioli, Roberto, Mosca, Luciana, Piacentini, Lucia, Trovato, Maurizio, Wessjohann, Ludger   +10 more
core   +1 more source

Phytochemical Contents and Bioactive Compounds in Widely Consumed Cereals, Legumes, and Vegetables in Abruzzo Region, Italy: A Critical Review

Food Safety and Health, EarlyView.
This review aims to collect and identify cereals, legumes, and vegetables mostly consumed in the Abruzzo region from 2020 till now, pointing attention to their biological effects. ABSTRACT The Abruzzo region boasts a wide range of typical food products including cereals, legumes, and vegetables. In this context, they take part in the Mediterranean diet,
Giulia Gentile, Lorenza Marinaccio, Adriano Mollica, Azzurra Stefanucci   +3 more
wiley   +1 more source

Wild-type macrophages reverse disease in heme oxygenase 1-deficient mice.

Blood, 2014
Loss-of-function mutation in the heme oxygenase 1 (Hmox1) gene causes a rare and lethal disease in children, characterized by severe anemia and intravascular hemolysis, with damage to endothelia and kidneys.
G. Kovtunovych, M. Ghosh, Wade Ollivierre, R. Weitzel, M. Eckhaus, J. Tisdale, A. Yachie, T. Rouault   +7 more
semanticscholar   +1 more source

The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance

Glia, EarlyView.
Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons during rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic lipids and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production of ...
Rose Follis, Vishwanath V. Prabhu, Bruce D. Carter   +2 more
wiley   +1 more source

Heme oxygenase-1: a metabolic nike.

Antioxidants and Redox Signaling, 2014
SIGNIFICANCE Heme degradation, which was described more than 30 years ago, is still very actively explored with many novel discoveries on its role in various disease models every year. RECENT ADVANCES The heme oxygenases (HO) are metabolic enzymes that
B. Wegiel, Zsuzsanna Nemeth, Matheus Correa-Costa, A. Bulmer, L. Otterbein   +4 more
semanticscholar   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases

Ibrain, EarlyView.
Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka, Mariafrancesca Cascione, Paolo Pellegrino, Annalisa Bianco, Stefano Leporatti, Valeria De Matteis   +5 more
wiley   +1 more source

Opuntia ficus‐indica fruit consumption improves insulin resistance in mice with diet‐induced obesity

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Obesity induces various co‐morbidities including insulin resistance. Opuntia ficus‐indica fruit (OFIF) is rich in various beneficial compounds with antioxidant and anti‐inflammatory properties. The present study evaluated the efficacy of OFIF supplementation to counteract obesity‐induced insulin resistance in comparison with an ...
Simona Terzo, Pasquale Calvi, Ignazio Restivo, Alessandro Massaro, Luisa Tesoriere, José‐Manuel Fernández‐Real, Marta Giardina, Antonella Amato, Flavia Mulè, Mario Allegra   +9 more
wiley   +1 more source

Monotropein Induced Ferroptosis to Alleviate the Progression of Hepatocellular Carcinoma via Regulating Nrf2/HO‐1/GPX4 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) exhibits a high global morbidity rate and ranks as the fourth leading cause of cancer‐related mortality worldwide. In response to the urgent need for effective HCC treatments, naturally occurring, botanical‐driven compounds have gained increasing attention.
Bing Shi, Yan‐Ping Li, Zhuo Gan, Pan Chen   +3 more
wiley   +1 more source

A low oxygen threshold for physiological responses and trace metal quotas of Prochlorococcus and Synechococcus

Limnology and Oceanography, EarlyView.
Abstract Continued human activity is expected to accelerate ocean deoxygenation, leading to the expansion and shallowing of oxygen‐deficient zones (ODZs). This decline in oxygen may impact both phytoplankton growth and trace metal uptake. We conducted culture experiments with Prochlorococcus MIT9313 and Synechococcus XM‐24, two numerically dominant ...
Joan De Vera, Yuanyuan Feng, Feixue Fu, Shun‐Chung Yang, Amjad Mansour, Nicholas J. Hawco, David A. Hutchins, Seth G. John   +7 more
wiley   +1 more source