Results 121 to 130 of about 133,631 (206)

Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians

Aging Cell, EarlyView.
Circulating factors are strongly implicated in modulating biological aging. In this study we show that the serum proteomic and metabolomic profile of high functioning octogenarians suggests lower activation of SASP, preservation of the tryptophan‐kynurenic pathway, higher lipophosphatidyl cholines promoting mitochondrial function, and reduced ...
Ceereena Ubaida‐Mohien, Ruin Moaddel, Sally Spendiff, Norah J. MacMillan, Marie‐Eve Filion, Jose A. Morais, Julián Candia, Liam F. Fitzgerald, Tanja Taivassalo, Paul M. Coen, Luigi Ferrucci, Russell T. Hepple   +11 more
wiley   +1 more source

The Heme Oxygenase/Biliverdin Reductase System and Its Genetic Variants in Physiology and Diseases. [PDF]

Antioxidants (Basel)
Mancuso C.
europepmc   +1 more source

Therapeutic potential of hesperidin in diabetes mellitus‐induced erectile dysfunction through Nrf2‐mediated ferroptosis and oxidative stress

Andrology, EarlyView.
Abstract Background Among erectile dysfunction (ED) caused by metabolic abnormalities, diabetes mellitus‐induced ED (DMED) progresses rapidly, manifests with severe symptoms, and shows reduced responsiveness to conventional medications. Hyperglycemia in the corpus cavernosum has been linked to the induction of both ferroptosis and oxidative stress ...
Sheng Xin, Wen Song, Jiaquan Mao, Peng Hu, Zhong Chen, Jihong Liu, Xiaodong Song, Qian Fang, Kai Cui   +8 more
wiley   +1 more source

On the Therapeutic Potential of Heme Oxygenase-1 and Its Metabolites. [PDF]

Antioxidants (Basel)
Stec DE.
europepmc   +1 more source

NADPH-Independent Fluorescent Probe for Live-Cell Imaging of Heme Oxygenase-1. [PDF]

ACS Sens
Li L, Lu X, He Q, Shu C, Walter ERH, Wang L, Long NJ, Jiang L.   +7 more
europepmc   +1 more source

Heme Regulatory Motif of Heme Oxygenase-2 Is Involved in the Interaction with NADPH-Cytochrome P450 Reductase and Regulates Enzymatic Activity. [PDF]

Int J Mol Sci
Sugishima M, Kusumoto T, Sato H, Sakamoto H, Higashimoto Y, Yamamoto K, Taira J.   +6 more
europepmc   +1 more source

Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation.

Translational research : the journal of laboratory and clinical medicine, 2016
S. Ryter, A. Choi
semanticscholar   +1 more source

Heme oxygenase 1 confers gilteritinib resistance in FLT3-ITD acute myeloid leukemia in a STAT6-dependent manner. [PDF]

Cancer Cell Int
Zhang T, Wei D, Zhan Y, Long Z, Lu T, Zhao P, Gao R, Kang Q, Zhang L, Liu M, Yang X, Wang J.   +11 more
europepmc   +1 more source

Understanding erythroid physiology and pathology in humanized mice: A closer look

British Journal of Haematology, EarlyView.
Erythropoiesis, the formation of red blood cells (RBCs) from haematopoietic stem cells (HSCs), is vital for understanding conditions like anaemia and haemoglobinopathies. However, studying this process in vivo is challenging due to the lack of accurate models.
Lu Lu, Chenfei Liu, Lezong Chen, Xumiao Zhang, Yinglin Su, Zhenzhen Chou, Yang Liang, Yuanbin Song   +7 more
wiley   +1 more source

Heme oxygenase-1: potential therapeutic targets for periodontitis. [PDF]

PeerJ
Lv W, Hu S, Yang F, Lin D, Zou H, Zhang W, Yang Q, Li L, Chen X, Wu Y.   +9 more
europepmc   +1 more source