Results 121 to 130 of about 188,137 (274)

Therapeutic potential of hesperidin in diabetes mellitus‐induced erectile dysfunction through Nrf2‐mediated ferroptosis and oxidative stress

Andrology, EarlyView.
Abstract Background Among erectile dysfunction (ED) caused by metabolic abnormalities, diabetes mellitus‐induced ED (DMED) progresses rapidly, manifests with severe symptoms, and shows reduced responsiveness to conventional medications. Hyperglycemia in the corpus cavernosum has been linked to the induction of both ferroptosis and oxidative stress ...
Sheng Xin, Wen Song, Jiaquan Mao, Peng Hu, Zhong Chen, Jihong Liu, Xiaodong Song, Qian Fang, Kai Cui   +8 more
wiley   +1 more source

Diagnostics of Autoimmune Hepatitis Enabled by Non‐Invasive Clinical Proteomics

Alimentary Pharmacology &Therapeutics, EarlyView.
Mass‐spectrometry‐based proteomic analyses of paired liver‐plasma samples from patients with AIH enabled discovery of numerous proteins showing high diagnostic accuracy. Proteomics may constitute a novel non‐invasive diagnostic tool for AIH if validated in larger, age‐ and sex‐matched cohorts.
Anne‐Sofie Houlberg Jensen, Henriette Ytting, Annelaura Bach Nielsen, Mikkel Parsberg Werge, Elias Badal Rashu, Liv Eline Hetland, Mira Thing, Puria Nabilou, Johan Burisch, Anders Ellekær Junker, Lise Hobolth, Christian Mortensen, Flemming Tofteng, Flemming Bendtsen, Søren Møller, Mogens Vyberg, Reza Rafiolsadat Serizawa, Marie Winther‐Sørensen, Jesper Sloth Kellemann, Lise Lotte Gluud, Nicolai Jacob Wewer Albrechtsen   +20 more
wiley   +1 more source

Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential

British Journal of Pharmacology, EarlyView.
Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Kelsey G. Guenther, Andrea G. Hohmann
wiley   +1 more source

Isolation and Characterization of a cDNA from the Rat Brain that Encodes Hemoprotein Heme Oxygenase‐3 [PDF]

, 1997
William K. McCoubrey, Tony Jun Huang, Mahin D. Maines   +2 more
openalex   +1 more source

Multiplicity of Heme Oxygenase Isozymes

, 1989
G M Trakshel, M D Maines
openalex   +1 more source

Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress [PDF]

, 1998
Ildikó Horváth, Louise Donnelly, András Kiss, Paolo Paredi, Sergei A. Kharitonov, Peter J. Barnes   +5 more
openalex   +1 more source

The Carba Mix—In Vitro Investigations of Potential Cocktail Effects in Patch Tests With Rubber Allergens

Contact Dermatitis, EarlyView.
The carba mix was studied in a human cell model to better understand human patch reactions to the mix. Our results support that the carba mix can give rise to cocktail effect and that patch testing with separate carba mix sensitisers may thus be more appropriate.
Linda Ljungberg Silic, Renato Ivan de Ávila, Sofía Carreira‐Santos, Gábor Merényi, Ola Bergendorff, Kathrin S. Zeller   +5 more
wiley   +1 more source

Induction of heme oxygenase in rat liver. Increase of the specific mRNA by treatment with various chemicals and immunological identity of the enzymes in various tissues as well as the induced enzymes.

, 1983
S. Ishizawa, Tadashi Yoshida, Goro Kikuchi   +2 more
openalex   +1 more source

Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. [PDF]

, 1998
Phyllis A. Dennery, Douglas R. Spitz, Gangyi Yang, Arthur Tatarov, C S Lee, Mychelle Shegog, Kenneth D. Poss   +6 more
openalex   +1 more source

KYNA Ameliorates Hepatic Ischemia–Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO‐Dependent m6A Demethylation of LATS1

Cell Proliferation, EarlyView.
Our study elucidates the cellular and molecular mechanisms underlying KYNA's protective effects against HIRI. It emphasises that KYNA modulates the methylation status of the Hippo signalling pathway through the activation of AHR, thereby mitigating damage by promoting LATS1 degradation and facilitating the nuclear translocation of YAP. ABSTRACT Hepatic
Wenjie Zheng, Xiaowen Wang, Haoqi Chen, Kaiming He, Xijing Yan, Yuan Zhang, Yang Yang, Peng Zhang, Wenfeng Zhu, Shuguang Zhu, Hua Li   +10 more
wiley   +1 more source