Results 181 to 190 of about 60,693 (303)

A Dynamic DNA Nano‐Antioxidant Targeting Galectin‐3 Attenuates Liver Fibrosis via Reducing Macrophage Oxidative Stress

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study developed a dynamic DNA nano‐antioxidant (DDN) for Galectin‐3 siRNA delivery, specifically targeting hepatic macrophages to suppress ROS‐driven fibrosis. DDN enhanced hepatic accumulation, restored NRF2 signaling, and attenuated oxidative stress, collagen deposition, and fibrotic progression in a CCl4‐induced cirrhosis model, demonstrating ...
Mengjia Peng, Jianguo Xu, Youjian Hong, Fei Fang, Yan Li, Duo Ci, Bowen Wang   +6 more
wiley   +1 more source

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

Advanced Science, Volume 13, Issue 1, 5 January 2026.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu, Peng Qu, Jiao Shi, Tingting Liang, Yao Gu, Xue Li, Cui Ma, Danyang Zhao, Feila Liu, Qi Liang, Panke Cheng, Qian Lei   +11 more
wiley   +1 more source

Heme Oxygenase-1 Expression as a Prognostic Marker in Early-Stage HCC Undergoing Resection or Liver Transplantation. [PDF]

Life (Basel)
Cadar R, Vasilescu AM, Trofin AM, Nastase AG, Zabara M, Muzica C, Ursulescu CL, Danciu M, Pascu A, Buzincu I, Ciobanu D, Victor I, Lupascu CD.   +12 more
europepmc   +1 more source

Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu, Bingxing An, Jumei Zheng, Qiao Wang, Zhirui Yang, Zhengda Li, Dawei Liu, Fan Ying, Jie Wen, Lingzhao Fang, Guiping Zhao   +10 more
wiley   +1 more source

Inhibitory Potency of a Plant-Based Zinc Protoporphyrin on Heme Oxygenase Activity.

Neonatology
Muchová L, Reddy GSKK, Wells GS, Zhao H, Vreman HJ, Wong RJ, Stevenson DK.   +6 more
europepmc   +1 more source

The promoter T-413A variant and elevated enzyme levels of heme oxygenase-1 associated with an increased risk of polycystic ovarian syndrome. [PDF]

Front Endocrinol (Lausanne)
Wang Q, Liang J, Liu Q, Liu H, Bai H, Huang W, Fan P.   +6 more
europepmc   +1 more source

Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction [PDF]

, 2005
Ikuo Nakamichi
openalex   +1 more source

Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders: A Current Review

BioFactors, Volume 52, Issue 1, January/February 2026.
Resveratrol induces the expressions of TP53, NRF2, and JDP2 axis in cancer cells to control ROS balance in mitochondria. The antioxidation responses were induced through SRIT1/3, HDAC, STAT3, TGFβ, and so on, to trigger the inflammation, and NFkB response to lead to the cell death of cancers or neuro‐damaged cells.
Kenly Wuputra, Chia‐Che Ku, Ying‐Chu Lin, Yi‐Chun Tsai, Deng‐Chyang Wu, Yukio Mitsui, Maki Satou, Yuuki Tanaka, Shigeo Saito, Kazunari K. Yokoyama   +9 more
wiley   +1 more source

An oral heme oxygenase inhibitor targets immunosuppressive perivascular macrophages in preclinical models of cancer. [PDF]

Sci Transl Med
Bahri M, Al-Adhami T, Demirel E, Sarkar J, Feehan KT, Anstee JE, Cheung TS, Sosnowska D, Woodman CA, Macmorland W, Yang DD, Rosekilly J, Gitsaki-Taylor R, Gillett CE, Scudamore CL, Spicer J, Rahman KM, Arnold JN.   +17 more
europepmc   +1 more source

A Growth‐Coupled Evolutionary Strategy Enhances Heme Biosynthesis in Saccharomyces cerevisiae

Biotechnology Journal, Volume 21, Issue 1, January 2026.
Graphical Abstract and Lay Summary Introducing a plasmid with a heme‐responsive promoter connected to a growth‐promoting gene into Saccharomyces cerevisiae created a positive feedback loop between intracellular heme levels and cell growth. After 100 h of adaptive evolution, the plasmid was removed, resulting in a mutant strain that exhibited an ...
Seoyoon Bang, Eunbi Kim, Sehyeon Park, Pil Kim   +3 more
wiley   +1 more source