Results 41 to 50 of about 51,151 (156)
Cytoprotective role of heme oxygenase-1 upregulation in progressive renal disease [PDF]
Einstein (São Paulo), 2009 Objective: This study evaluated the ability of heme oxygenase-1 to prevent or reverse renal fibrosis. Methods: Sprague-dawley male rats were submitted to unilateral ureteral obstruction and divided into groups: non-treated and hemin.
Matheus Corrêa Costa +9 more
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Naringin Decreases TNF-α and HMGB1 Release from LPS-Stimulated Macrophages and Improves Survival in a CLP-Induced Sepsis Mice. [PDF]
PLoS ONE, 2016 Naringin, a flavanone glycoside extracted from various plants, has a wide range of pharmacological effects. In the present study, we investigated naringin's mechanism of action and its inhibitory effect on lipopolysaccharide-induced tumor necrosis factor-
Minchan Gil +3 more
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Heme oxygenase-1 and cardiovascular disease.
Histology and histopathology, 2006 Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-controlling enzyme of heme degradation. HO-1 is up-regulated by a host of oxidative stress stimuli and has potent cytoprotective and anti-inflammatory functions via decreasing tissue levels of the prooxidant heme along with production of bilirubin and the signaling gas carbon monoxide.
Immenschuh, S., Schröder, H.
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Heme Oxygenase-1 Increases Endothelial Progenitor Cells [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2009 Objectives— Induction of heme oxygenase-1 (HO-1) protects against atherosclerotic disease in part by promoting reendothelialization. As endothelial progenitor cells (EPCs) contribute to reendothelialization, we examined the role of HO-1 on bone marrow and circulating EPCs.
Ben J, Wu +7 more
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Heme oxygenase 1 overexpression increases iron fluxes in Caco-2 cells
Biological Research, 2006 Heme oxygenase-1 is a microsomal enzyme that, when induced by stress, protects the cells from oxidative injury. Heme oxygenase-1 participates in the cleavage of the heme ring producing biliverdin, CO and ferrous Fe.
MARÍA JOSE MENDIBURO +3 more
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Enzymological and structural characterization of Arabidopsis thaliana heme oxygenase‐1
FEBS Open Bio, 2022 Arabidopsis thaliana heme oxygenase‐1 (AtHO‐1), a metabolic enzyme in the heme degradation pathway, serves as a prototype for study of the bilin‐related functions in plants.
Jia Wang +6 more
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Pharmacological Targeting of Heme Oxygenase-1 in Osteoarthritis
Antioxidants, 2021 Osteoarthritis (OA) is a common aging-associated disease that clinically manifests as joint pain, mobility limitations, and compromised quality of life.
Yohei Sanada +3 more
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Heme oxygenase 1 alleviates nonalcoholic steatohepatitis by suppressing hepatic ferroptosis
Lipids in Health and Disease, 2023 Background Heme oxygenase 1 (HO-1) has an influential but insufficiently investigated effect on ferroptosis, which is a novel form of programmed cell death and may play an effect on nonalcoholic steatohepatitis (NASH).
Xiwei Yuan +9 more
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Iranian Journal of Allergy, Asthma and Immunology, 2013 Up-regulation of CD4+CD25+CD127low/- regulatory T cells (Tregs) is a new target in the treatment of asthma. Human bone marrow mesenchymal stem cells can up-regulate CD4+CD25+CD127low/- regulatory T cells in vitro, meanwhile, heme oxygenase-1 (HO-1 ...
Jian-guo Li +6 more
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Crystallization of recombinant human heme oxygenase‐1 [PDF]
Protein Science, 1998 AbstractHeme oxygenase catalyzes the NADPH, 02, and cytochrome P450 reductase dependent oxidation of heme to biliverdin and carbon monoxide. One of two primary isozymes, HO‐1, is anchored to the endoplasmic reticulum membrane via a stretch of hydrophobic residues at the C‐terminus.
D J, Schuller +3 more
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