Results 1 to 10 of about 22,924 (125)
Antioxidants, 2022 The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO), ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin reductase (BVR).
S. Ryter
semanticscholar +1 more source
Roles of Heme Oxygenase-1 in Neuroinflammation and Brain Disorders
Antioxidants, 2022 The heme oxygenase (HO) system is believed to be a crucial mechanism for the nervous system under stress conditions. HO degrades heme to carbon monoxide, iron, and biliverdin.
Yi‐Hsuan Wu, H. Hsieh
semanticscholar +1 more source
Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions
Biomolecules, 2021 Heme-oxygenase is the enzyme responsible for degradation of endogenous iron protoporphyirin heme; it catalyzes the reaction’s rate-limiting step, resulting in the release of carbon monoxide (CO), ferrous ions, and biliverdin (BV), which is successively ...
Valeria Consoli +3 more
semanticscholar +1 more source
Heme Oxygenase Modulation Drives Ferroptosis in TNBC Cells
International Journal of Molecular Sciences, 2022 The term ferroptosis refers to a peculiar type of programmed cell death (PCD) mainly characterized by extensive iron-dependent lipid peroxidation. Recently, ferroptosis has been suggested as a potential new strategy for the treatment of several cancers ...
Valeria Consoli +8 more
semanticscholar +1 more source
Blood, 2021 Sickle cell disease (SCD) is characterized by increased hemolysis which results in plasma heme overload and ultimately cardiovascular complications. Here, we hypothesized that increased heme in SCD causes upregulation of heme oxygenase 1 (Hmox1) which ...
Archita V. Menon +6 more
semanticscholar +1 more source
The Diverse Roles of Heme Oxygenase-1 in Tumor Progression
Frontiers in Immunology, 2021 Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in response to a variety of stimuli to degrade heme, which generates the biologically active catabolites carbon monoxide (CO), biliverdin and ferrous iron (Fe2+).
K. N. Luu Hoang +2 more
semanticscholar +1 more source
Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress
Antioxidants, 2021 Atherosclerosis remains the underlying process responsible for cardiovascular diseases and the high mortality rates associated. This chronic inflammatory disease progresses with the formation of occlusive atherosclerotic plaques over the inner walls of ...
Jose Angel Alonso-Piñeiro +4 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2021 Since Yachie et al. reported the first description of human heme oxygenase (HO)-1 deficiency more than 20 years ago, few additional human cases have been reported in the literature.
A. Yachie
semanticscholar +1 more source
Heme Oxygenase-1 as a Novel Metabolic Player
Oxidative Medicine and Cellular Longevity, 2013 Heme oxygenase (HO; EC 1:14.99.3, heme, hydrogen donor: oxygen oxidoreductase (α-methene hydroxylating, decyclizing)) catalyzes the rate limiting the step in the oxidative catabolism of heme to generate biliverdin-IXα, which is subsequently converted to ...
Hun-taeg Chung, S. Ryter, Hong-pyo Kim
semanticscholar +1 more source
Frontiers in Immunology, 2020 Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors.
S. C. Funes +7 more
semanticscholar +1 more source