Results 41 to 50 of about 2,013 (172)

Murburn Concept: A Molecular Explanation for Hormetic and Idiosyncratic Dose Responses

Dose-Response, 2018
Recently, electron transfers and catalyses in a bevy of redox reactions mediated by hemeproteins were explained by murburn concept. The term “murburn” is abstracted from “ mur ed burn ing ” or “ m ild u n r estricted burn ing ” and connotes a novel “ m ...
Abhinav Parashar, Daniel Andrew Gideon, Kelath Murali Manoj   +2 more
doaj   +1 more source

Development of Bioorthogonally Degradable Tough Hydrogels Using Enamine N‐Oxide Based Crosslinkers

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
Inducibly degradable enamine N‐oxide crosslinkers are integrated into tough double network hydrogels, enabling rapid and bioorthogonal degradation by aqueous diboron solutions. These chemical reagent‐responsive biomaterials maintain structural integrity during use while enabling rapid degradation when needed, making them ideal for applications in ...
Thomas T. Kim, Deep Malu, Dongjing He, Yuhang Hu, Justin Kim   +4 more
wiley   +1 more source

Evolutionary Pro‐To‐Thr Mutation in the Intrinsically Disordered Domain of ANP32 Family Members Modulates Their Target Binding Modes

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Protein evolution usually lies on mutations at disordered domains to promote novel functions and regulations. Here it is demonstrated that this is the case of ANP32A and ANP32B, two paralogs with apparently similar structures and functions, where a single amino‐acid substitution in the disordered domain triggers the extended‐to‐compact conformational ...
Blanca Baños‐Jaime, Ana B. Uceda‐Mayo, Francisco Rivero‐Rodríguez, Miguel Á. Casado‐Combreras, Alejandro Velázquez‐Cruz, Adrián Velázquez‐Campoy, Laura Corrales‐Guerrero, Miguel A. De la Rosa, Irene Díaz‐Moreno   +8 more
wiley   +1 more source

THE DETERMINATION OF ELECTRONIC PROPERTIES BY PROTEIN STRUCTURE IN HEMEPROTEIN

Seibutsu Butsuri, 1961
Rufus Lumry
openaire   +4 more sources

Phosphorylation of cytochrome c at tyrosine 48 finely regulates its binding to the histone chaperone SET/TAF‐Iβ in the nucleus

Protein Science, Volume 33, Issue 12, December 2024.
Abstract Post‐translational modifications (PTMs) of proteins are ubiquitous processes present in all life kingdoms, involved in the regulation of protein stability, subcellular location and activity. In this context, cytochrome c (Cc) is an excellent case study to analyze the structural and functional changes induced by PTMS as Cc is a small ...
Joaquin Tamargo‐Azpilicueta, Miguel Á. Casado‐Combreras, Rafael L. Giner‐Arroyo, Adrián Velázquez‐Campoy, Inmaculada Márquez, José L. Olloqui‐Sariego, Miguel A. De la Rosa, Irene Diaz‐Moreno   +7 more
wiley   +1 more source

Porphyrin Atropisomerism as a Molecular Engineering Tool in Medicinal Chemistry, Molecular Recognition, Supramolecular Assembly, and Catalysis

Chemistry – A European Journal, Volume 30, Issue 43, August 1, 2024.
Porphyrin atropisomerism opens an entirely new toolbox, allowing for the precise design of a porphyrin's molecular shape. This review details how this phenomenon has been utilised across all fields of chemistry, focusing on molecular recognition, medicinal chemistry and catalysis.
Sophie Maguire, Grant Strachan, Karolis Norvaiša, Claire Donohoe, Lígia C. Gomes‐da‐Silva, Mathias O. Senge   +5 more
wiley   +1 more source

The flavohemoglobin Yhb1 is a new interacting partner of the heme transporter Str3

Molecular Microbiology, Volume 122, Issue 1, Page 29-49, July 2024.
A new mechanism for Yhb1 (orange) heme‐dependent activation involves direct interaction with the cell‐surface heme transporter Str3 (blue) in the presence of exogenous heme (red). Upon exposure to nitric oxide (˙NO), the expression of yhb1+ is induced, as its promoter is liberated from Fep1 repression (violet).
Florie Lo Ying Ping, Tobias Vahsen, Ariane Brault, Raphaël Néré, Simon Labbé   +4 more
wiley   +1 more source

Fungal systems for lignocellulose deconstruction: From enzymatic mechanisms to hydrolysis optimization

GCB Bioenergy, Volume 16, Issue 5, May 2024.
Biomass contains complex sugars and aromatic polymers that have the potential to serve as sustainable alternatives to fossil fuels and chemicals. Fungi possess specialized enzyme systems capable of breaking down lignocellulose into fermentable building blocks. This review analyses recent advancements in intricate fungal decomposition toolkits, shedding
Fengyun Ren, Fan Wu, Xin Wu, Tongtong Bao, Yucheng Jie, Le Gao   +5 more
wiley   +1 more source

Cultivating the uncultured: Harnessing the “sandwich agar plate” approach to isolate heme‐dependent bacteria from marine sediment

mLife, Volume 3, Issue 1, Page 143-155, March 2024.
Abstract In the classical microbial isolation technique, the isolation process inevitably destroys all microbial interactions and thus makes it difficult to culture the many microorganisms that rely on these interactions for survival. In this study, we designed a simple coculture technique named the “sandwich agar plate method,” which maintains ...
Jing Zhang, Qi‐Yun Liang, Da‐Shuai Mu, Fengbai Lian, Ya Gong, Mengqi Ye, Guan‐Jun Chen, Yuqi Ye, Zong‐Jun Du   +8 more
wiley   +1 more source

Permeability of rat choriocapillaris to hemeproteins. Restriction of tracers by a fenestrated endothelium. [PDF]

Journal of Histochemistry & Cytochemistry, 1981
The choriocapillaris is the fenestrated capillary bed in the choroid of the eye and is the major blood supply to the retinal pigment epithelium (RPE) and photoreceptor cells. Bruch's membrane (BM) is a multilaminated basement membrane that separates the choriocapillaris from the RPE. In a previous study (Pino RM, Essner E; Cell Tissue Res 208:21, 1980)
Edward Essner, Richard M. Pino
openaire   +2 more sources