Results 121 to 130 of about 34,452 (261)

Design, Synthesis, and Evaluation of Bis‐Chalcones and Bis‐Flavones as Selective COX‐2 Inhibitors

Chemical Biology &Drug Design, Volume 107, Issue 3, March 2026.
Novel bis‐chalcones were successfully synthesized and demonstrated COX‐2 selective inhibition and the ability to inhibit PGE2 production in whole human blood. Notably, a monomeric chalcone with a similar substitution pattern exhibited even greater activity, providing valuable insights to guide the future design and optimization of flavonoid‐based COX‐2
Rui Pereira, Marisa Freitas, Alberto N. Araújo, Vera L. M. Silva, Eduarda Fernandes   +4 more
wiley   +1 more source

Leishmania donovani's protein tyrosine phosphatases interact with DUF21 and respond to environmental magnesium

The FEBS Journal, Volume 293, Issue 6, Page 1754-1770, March 2026.
The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini, Hira Khursheed, Wen Wei Zhang, Isabelle Aubry, Greg Matlashewski, Michel L. Tremblay, Patrick Lypaczewski   +6 more
wiley   +1 more source

Therapeutic Hemin [PDF]

, 2020
openaire   +1 more source

Distribution and activity of nitrate and nitrite reductases in the microbiota of the human intestinal tract

The FEBS Journal, Volume 293, Issue 6, Page 1624-1642, March 2026.
Nitrate from food is first converted to nitrite by oral bacteria and then further processed in the intestine. The gut microbiota reduces nitrate and nitrite to ammonia or nitric oxide, preventing the formation of carcinogenic nitrosamines. Our analysis highlights Escherichia coli as a key player in this detoxification process, supported by other ...
Natalie Hager, Mélanie Elisabeth Gindt, Marcel Hövels, Jean‐Lou Christian Michel Dorne, Uwe Deppenmeier   +4 more
wiley   +1 more source

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source

Bafilomycin A1 is a promising therapeutic agent against T. spiralis infection by inhibiting the heme-transporting ATP6V0C/HRG-1 complex. [PDF]

PLoS Pathog
He Y, Wang Y, He X, Lv Q, Vallee I, Boireau P, Ding J, Liu X.   +7 more
europepmc   +1 more source

Receptor-Dependent and -Independent Effects of Hemin on Platelet Plasma Membrane Disintegration. [PDF]

FASEB J
Laspa Z, Rohlfing AK, Hochuli R, Sowa PW, Castor T, Gawaz MP.   +5 more
europepmc   +1 more source

Transcriptomic response to different heme sources in <i>Trypanosoma cruzi</i> epimastigotes. [PDF]

Microb Cell
Tevere E, Mediavilla MG, Di Capua CB, Merli ML, Robello C, Berná L, Cricco JA.   +6 more
europepmc   +1 more source

Hemin@carbon dot hybrid nanozymes with peroxidase mimicking properties for dual (colorimetric and fluorometric) sensing of hydrogen peroxide, glucose and xanthine

Microchimica Acta, 2020
Li Su, Yexi Cai, Liang Wang, Wenpei Dong, Guo-jiang Mao, Ye Li, Mingsheng Zhao, Yanhua Ma, Hua Zhang   +8 more
semanticscholar   +1 more source

<i>In vitro</i> activity of gallium-protoporphyrin IX against <i>Leishmania major</i> and <i>Leishmania infantum</i>. [PDF]

Microbiol Spectr
Maestrini S, Diotallevi A, Hijazi S, Habouria S, Frangipani E, Galluzzi L.   +5 more
europepmc   +1 more source